Article
Veterinary Sciences
Kelsey L. Johnson, Torrey Tiedeman, Hannah Peterson, Joerg M. Steiner, Lauren A. Trepanier
Summary: The study found that Greyhounds have higher concentrations of homocysteine in their blood compared to non-sighthound control dogs. It also identified a likely metabolic pathway defect in converting homocysteine to methionine in Greyhounds. Additionally, the study found an inverse correlation between homocysteine and serum concentrations of folate and cobalamin. Overall, these findings suggest a primary defect in homocysteine metabolism, impaired folate generation, and secondary cobalamin depletion in Greyhounds.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Editorial Material
Endocrinology & Metabolism
May Yin Lee, Wai Leong Tam
Summary: By using multimodal metabolomics technologies, Vande Voode et al. discovered tumor genotype-specific metabolic profiles and identified the methionine-cycle enzyme AHCY as a potential therapeutic target in colorectal cancer.
Article
Chemistry, Multidisciplinary
Yanyan Liao, Shunmin Zhang, Xuefeng Jiang
Summary: Thioamide peptides were synthesized in a one-pot process by linking natural amino acids in the presence of thiolphosphonate and trichlorosilane, with minimal racemization. Experimental and computational studies showed that trichlorosilane enables the activation of carboxylic acids and coupling with thiolphosphonate to obtain the intermediate S-acyl dithiophosphate. Silyl-activated quadrangular metathesis transition states resulted in the formation of thioamide peptides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Cameron D. Fyfe, Noelia Bernardo-Garcia, Laura Fradale, Stephane Grimaldi, Alain Guillot, Clemence Brewee, Leonard M. G. Chavas, Pierre Legrand, Alhosna Benjdia, Olivier Berteau
Summary: Methyl-coenzyme M reductase plays a central role in regulating global methane levels. The study of Methanosarcina acetivorans' Mmp10 provides insights into its unique enzyme structure and catalytic control mechanism, as well as the structural changes prior to catalysis. This research is important for understanding the catalytic mechanism of the emerging superfamily of B-12-dependent radical SAM enzymes.
Article
Biochemistry & Molecular Biology
Matthew Scott Schrier, Yiting Zhang, Malav Suchin Trivedi, Richard Carlton Deth
Summary: A study found that the Nrf2 gene (NFE2L2) was downregulated in the frontal cortex of individuals with autism spectrum disorder (ASD), along with differences in other genes involved in redox homeostasis. Additionally, methylcobalamin(III) (MeCbl) and total cobalamin abundance were positively correlated with NFE2L2 expression, while hydroxocobalamin(III) (OHCbl) showed a negative correlation. These findings highlight a dysfunctional relationship between the antioxidant-promoting role of Nrf2 and cobalamin status in ASD.
Article
Biotechnology & Applied Microbiology
Sandra Lehner, Eckhard Boles
Summary: This study found that replacing the B12-independent protein Met6 of yeast with the B12-dependent protein MetH from Escherichia coli requires high-level expression of an exogenous bacterial system to activate MetH activity and promote growth. This research provides a new method for engineering vitamin B12-producing yeast cells.
FEMS YEAST RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Zehra Gul Coban, Yusuf Yagci, Baris Kiskan
Summary: Thioamide was synthesized as a catalyst to lower the ring-opening polymerization temperature of simple 1,3-benzoxazines and its catalytic performance could be enhanced by mixing with Cu(II) benzoate. The catalyzed polybenzoxazines showed higher thermal stability and char yield increment compared to uncatalyzed polybenzoxazines.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yongjiao Wei, Yinghui Liu, Lan-Gui Xie
Summary: The Beckmann rearrangement and following cascade reactions have been developed by using Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent. This method allows the conversion of various ketoximes into different compounds.
CHINESE CHEMICAL LETTERS
(2022)
Review
Biochemical Research Methods
Elnaz Jalali, Jon S. Thorson
Summary: Transferases are highlighted as effective catalysts for enzyme-mediated bioorthogonal functional group installation in various biological applications. The focus of this review is on the key technologies and applications of methyltransferases (MTs) in bioorthogonal labeling and conjugation reactions involving DNA, RNA, proteins, and natural products.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hu Liu, Xuexiang Li, Zhenhui Ma, Mingzi Sun, Menggang Li, Zhenyu Zhang, Liang Zhang, Zuobin Tang, Yao Yao, Bolong Huang, Shaojun Guo
Summary: The researchers have developed a new strategy to incorporate single atom Cu sites into melem ring, resulting in Cu-1/CN catalyst with high selectivity, activity, and stability for selective hydrogenation of 4-nitrostyrene. The presence of hydroxymethyl from trimethylolmelamine is found to be beneficial for atomically dispersing Cu atoms in CN, contributing to the optimal chemical environment for efficient hydrogenation reaction. X-ray absorption fine structure tests indicate that the Cu atom of Cu-1/CN is dominated by quaternary coordination way in the melem ring of CN.
Article
Chemistry, Multidisciplinary
Yueyao Chen, Jesse Ling, Angus B. Keto, Yun He, Kam-Hung Low, Elizabeth H. Krenske, Pauline Chiu
Summary: Epoxy and aziridinyl enolsilanes can react as oxyallylic cation equivalents in highly selective and stereoselective intramolecular (3+2) cycloadditions. Computational studies suggest that the stepwise reaction involves the conformational flexibility of the intermediate, which determines the formation of (3+2) cycloadducts. This method can be used for the synthesis of densely functionalized trans-hydrindane scaffolds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ruslan Gibadullin, Rylie K. Morris, Jiani Niu, John Sidney, Alessandro Sette, Samuel H. Gellman
Summary: This study introduces a new strategy for modifying MHC I antigens to enhance resistance to proteolysis while preserving MHC I affinity and T cell activation properties. The use of thioamides as replacements for backbone amide groups resulted in potent vaccine candidates that resist degradation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Qingyu Wang, Yajing Liu, Shuo Dong, Yongqiang Zhang, Youcheng Zhu, Yu Tian, Jingwen Li, Zhuoyi Wang, Ying Wang, Fan Yan
Summary: Genetically modifying soybeans to increase the content of the sulfur-containing amino acid methionine can improve the nutritional quality of soybean protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yiping Liu, Taowei Zhong, Xinli Song, Senmao Zhang, Mengting Sun, Jianhui Wei, Jing Shu, Tubao Yang, Tingting Wang, Jiabi Qin
Summary: In this hospital-based case-control study, we found significant associations between genetic polymorphisms of the methionine synthase (MTR) gene at rs1805087 and rs2275565 and the risk of non-syndromic congenital heart disease (CHD). Additionally, we observed significant associations between three haplotypes and CHD risk.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Emmanuel Scalais, Christine Geron, Charlotte Pierron, Sandra Cardillo, Vincent Schlesser, Frederic Mataigne, Patricia Borde, Luc Regal
Summary: Hydroxocobalamin dose-intensification (OHCBL-DI) improved biochemical and clinical outcome in patients with early-onset cblC deficiency. Pathogenic variants in MMACHC disrupt the synthesis of methyl-cobalamin and 5'-deoxyadenosyl-cobalamin, which are important cofactors for methionine synthase and methyl-malonyl-CoA mutase enzymes. By bypassing MMACHC and utilizing methionine synthase reductase and adenosyltransferase, OHCBL-DI improves cognitive and retinal function.
MOLECULAR GENETICS AND METABOLISM
(2023)
Review
Chemistry, Analytical
Nadeem A. Khan, Sirajuddin Ahmed, Izharul Haq Farooqi, Imran Ali
Summary: The article discusses the application of various technologies in the treatment of pharmaceutical and wastewater. It highlights the need for better technologies to improve removal rates of certain elements that inhibit neurotransmitter activity and proliferation. Additionally, the combination of activated sludge and membrane filtration bioreactors shows higher removal efficiency, while ozonation enhances biodegradability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Imran Ali, Stoyanova Alyona, Kon'kova Tatiana, Gaydukova Anastasiya, Hassan M. Albishri, Wael Hamad Alshitari
Summary: A sorption-electroflotation method using carbon nanomaterials was developed to remove non-biodegradable and carcinogenic toxic metal ions. Carbon nanotubes (CNTs) and carbon nanoshells (CNSs) were used to remove Ni(II), Co(II), Zn(II), Fe(II), and Cu(II). Surface properties and composition of the nanomaterials were characterized, and different models were applied to analyze the data. The method showed excellent removal efficiency, with the highest percentage removal achieved through simultaneous sorption-electroflotation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Imran Ali, Hokman Mahmudov, Gunel Imanova, Telman Suleymanov, Ahmed M. Hameed, Ahmed Alharbi
Summary: Hydrogen production through water splitting using Al2O3 nanoparticles as a radiation catalyst with gamma rays irradiation was studied. The effects of different particle sizes, surface area, amounts of radiation catalyst, and irradiation time were investigated. It was found that smaller-sized nanoparticles resulted in higher hydrogen production.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Analytical
Valentina Greco, Marcello Locatelli, Fabio Savini, Ugo de Grazia, Ottavia Montanaro, Enrica Rosato, Miryam Perrucci, Luigi Ciriolo, Abuzar Kabir, Halil Ibrahim Ulusoy, Cristian D'Ovidio, Imran Ali, Alessandro Giuffrida
Summary: This article discusses the primary cause of poor and ambiguous results in the bioanalytical process, which is sample pre-treatment, particularly in clinical analysis. It focuses on both classical and new techniques for pre-treatment of complex sample matrices. The use of green solvents and alternative biological samples like saliva, as well as new techniques that require minimal sample pre-treatment, are explored. The article is divided into sections on clinical applications and sample preparation techniques for diagnostic purposes.
Article
Materials Science, Multidisciplinary
Imran Ali, Teymur Agayev, Gunel T. Imanova, Hokman Mahmudov, Shahla Musayeva, Omar M. L. Alharbi, Mohammad Nahid Siddiqui
Summary: The production of economic green hydrogen fuel is in high demand. In this study, hydrogen generation by water radiolysis of a hexane-water system on ZrO2 surface was investigated at different temperatures. The radiation-catalytic decomposition of hexane-water increased at high temperatures and resulted in an increase in hydrogen production. At a temperature of 673 K, a chain mode conversion of the key products of hexane-water led to molecular hydrogen. The maximum yield of hydrogen achieved was 188.5 molecule/100 eV with the n-ZrO2 + C6H14(ads)-water (0.003 g: 0.0051 g: 0.0015 g) system at 673 K.
Review
Biochemistry & Molecular Biology
Cristian D'Ovidio, Marcello Locatelli, Miryam Perrucci, Luigi Ciriolo, Kenneth G. Furton, Isil Gazioglu, Abuzar Kabir, Giuseppe Maria Merone, Ugo de Grazia, Imran Ali, Antonio Maria Catena, Michele Treglia, Luigi T. Marsella, Fabio Savini
Summary: LC-MS/MS plays a crucial role in screening and tracking pharmacotoxicological and forensic cases due to its advanced features. This review paper focuses on its applications in pharmacotoxicology and highlights its importance in the development of pharmacological and forensic research. It discusses therapeutic drug monitoring and clinical approaches as well as the determination of illicit drugs.
Review
Chemistry, Multidisciplinary
Valentina Greco, Alessandro Giuffrida, Marcello Locatelli, Fabio Savini, Ugo de Grazia, Luigi Ciriolo, Miryam Perrucci, Abuzar Kabir, Halil Ibrahim Ulusoy, Cristian D'Ovidio, Imran Ali
Summary: This review focuses on the sample preparation for forensic analysis, including elimination of interferents, specimen cleanup, and extraction of analytes of interest to reduce matrix effect. The selection of literature provides a general overview of the state-of-the-art in this field. Different biological matrices, such as blood and urine, are commonly used to investigate substances related to death, while other body fluids like bile and oral fluids are still under discussion for their usability. The review also categorizes solid matrices obtained after autopsy into conventional and unconventional matrices for better understanding, considering widely used pretreatment techniques and representative innovative techniques.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemical Research Methods
Imran Ali, Murat Misir, Ersin Demir, Irem Dincer, Marcello Locatelli, Zeid A. ALOthman
Summary: A polymer-based nanosensor and electrochemical methods were developed for the quantitative analysis of vanillin. The sample preparation was done using nano solid phase micro membrane tip extraction (NSPMMTE). A novel poly(phenylalanine)/TiO2/CPE sensor was built as the working electrode for the first time for the analysis of the vanillin substance. The electrochemical behavior and analytical performance of vanillin were examined in detail by cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV) techniques via the oxidation process. The optimized modules of the DPSV technique that affected the vanillin peak current and peak potential were pH, pulse amplitude, step potential, and deposition time. The electroactive surface areas of bare CPE, TiO2/CPE, and poly(phenylalanine)/TiO2/CPE electrodes were found to be 0.135 cm2, 0.155 cm2, and 0.221 cm2, respectively. The limit of detection (LOD) was 32.6 μg/L in the 0.25-15.0 mg/L working range at pH 7.0. The selectivity of the proposed DPSV method for the determination of vanillin on the modified electrode was investigated in the presence of various organic and inorganic substances, and the determination of vanillin with high recovery was achieved with less than 5% relative error. The analytical application was applied in chocolate samples and the DPSV method was found highly efficient, reproducible, and selective.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Khadidja Addadi, Khaled Sekkoum, Nasser Belboukhari, Zeid A. ALOthman, Ahmed M. Aljuwayid, Mika Sillanpaa, Imran Ali
Summary: In this study, the enantio-separation of three chiral sulfoxide drugs was achieved on a Chiralpak AS-3R column using acetonitrile-water as the mobile phase. The chiral separation was validated properly with LOD and LOQ values of 9.70-14.16 and 29.39-42.91 μg/mL, respectively. The enantiomer elution order was confirmed through experimental and theoretical methods. A simple, fast, reliable, and thermodynamically stable HPLC method was developed for the separation and determination of enantiomer elution order of the chiral sulfoxide drugs.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Imran Ali, Anastasya Gaydukova, Tatiana Kon'kova, Zeid Abdullah ALOthman, Mika Sillanpaa
Summary: This study investigated the acid leaching process of grinding waste from a heat-resistant nickel alloy. Optimal conditions for acid dissolution were established to maximize the extraction of nickel, the main component of the alloy. These results are significant for industry professionals in metal recovery and environmentalists in waste treatment.
Article
Engineering, Chemical
Imran Ali, Aleksandr Shchegolkov, Aleksey Shchegolkov, Maksim Aleksandrovich Chumak, Nashchekin Alexey Viktorovich, Likhachev Kirill Vasilievich, Gunel Imanova, Tonni Agustiono Kurniawan, Mohamed A. Habila
Summary: Multi-walled carbon nanotubes (MWCNTs) synthesized by the microwave method were found to enhance the thermal and electrical conductivity of silicone elastomers. The highest thermal conductivity achieved was 0.48 W/m°C with 8.0 wt% MWCNTs, while the highest electrical conductivity reached 2.4 x 10-5 S/cm. Microwave-synthesized MWCNTs demonstrated high stability in an electrical resistance heater application, making them suitable for household appliances.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Energy & Fuels
Muhammad Sarfraz Arshad, Xavier Yangkou Mbianda, Imran Ali, Wanbing Guan, Tariq Kamal, Kimmo Kauhaniemi, Syed Zulqadar Hassan, Ghulam Yasin
Summary: This paper discusses the importance of nanomaterials in solid oxide fuel cells and the enhancement of active sites for electrode reactions through nanoengineering and composite approaches. The use of nanotechnology enables environmentally friendly and sustainable manufacturing processes for SOFCs. Additionally, the paper provides an overview of the applications of SOFCs, notable research institutions and companies, and future challenges and perspectives.
Article
Chemistry, Multidisciplinary
Imran Ali, Aicha Kraimi, Nasser Belboukhari, Khaled Sekkoum, Mouslim Messali
Summary: In order to enhance the anticoagulant activity of acenocoumarol, five new imino derivatives were synthesized and characterized. These derivatives were separated into their stereoisomers using chiral HPLC. The absolute configuration of all 20 stereoisomers was determined and their biological activities were predicted using DFT calculations.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Maha Hasni, Nasser Belboukhari, Khaled Sekkoum, Raluca-Ioana Stefan-van Staden, Zeid A. Alothman, Ersin Demir, Imran Ali
Summary: The essential oil of Heliotropium bacciferum plant has significant medicinal value, and this study extracted and analyzed its essential oil, as well as evaluated its anti-inflammatory and anti-bacterial activities. The results showed that the essential oil displayed effective anti-inflammatory and anti-bacterial properties, indicating its potential as a therapeutic agent.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Farhat Habib, Asghar Ali, Iram Irfan, Amir Azam, Mohammad Abid, Imran Ali
Summary: In this study, a series of novel 1,2,4-oxadiazole-sulfonamide conjugates were synthesized and evaluated for their antimicrobial activity. Compound 8d showed significant inhibitory activity against both Gram-positive and Gram-negative bacterial strains, and exhibited synergistic effect with some antibiotics. It also demonstrated favorable drug-like characteristics and no toxicity towards human red blood cells.
