Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 60, Issue 2, Pages 246-250Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.60.246
Keywords
Hedychium coronarium; hedycoronen A; hedycoronen B; tumor necrosis factor-alpha; interleukin-6; interleukin-12
Funding
- Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea (NRF) [2009-0093815, 2010-0023645]
- National Research Foundation of Korea [과09B2106, 2009-0093815, 2010-0023645] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxyl-abda-8(17),111,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1-3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC50 ranging from 4.1 +/- 0.2 to 9.1 +/- 0.3 mu M. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-alpha (TNF-alpha) production with IC50 values of 46.0 +/- 1.3 and 12.7 +/- 0.3 mu M. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.
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