Article
Materials Science, Multidisciplinary
Mohammed Almtiri, Timothy J. Dowell, Iwei Chu, David O. Wipf, Colleen N. Scott
Summary: Two polyaniline derivatives, P1 and P2, with outstanding electrochemical stability and high conductivity, particularly when exposed to m-cresol vapors, have been prepared by researchers. P1 exhibits highly conductive sheet-like structures in the presence of m-cresol vapor, making it suitable for applications requiring stable redox conductive polymers.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Laila M. Nhari, Elham N. Bifari, Aisha R. Al-Marhabi, Fatimah A. M. Al-Zahrani, Huda A. Al-Ghamdi, Sameera N. Al-Ghamdi, Abdullah M. Asiri, Reda M. El-Shishtawy
Summary: In this study, the Suzuki-Miyaura cross-coupling reaction was used to synthesize a series of new compounds containing phenothiazine (PTZ), phenoxazine (POZ), carbazole (Cz), and triphenylamine (TPA) as electron donors. The C-C coupling efficiency was found to be higher for electron-rich phenothiazine halides than for phenoxazine and carbazole analogues when coupled with either electron-rich or electron-deficient boronic acid precursors. Furthermore, the coupling efficiency of different boronic acid precursors with substituted phenothiazine halides was dependent on the electronic nature of both PTZ-halide and boronic acid precursors.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Koichi Mitsudo, Yasuyuki Okumura, Kotaro Yohena, Yuji Kurimoto, Eisuke Sato, Seiji Suga
Summary: Electrochemical dehydrogenative C-O bond formation was achieved for the synthesis of sultones. In the presence of K2CO3 and H2O, constant current electrolysis of [1,1'-biphenyl]-2-sulfonyl chloride resulted in quantitative formation of aryl-fused sultone. Control experiments suggest that electrochemical oxidation of sulfonates generates sulfo radical intermediates.
Article
Spectroscopy
Przemyslaw Krawczyk, Slawomir Kula, Klaudia Seklecka, Krzysztof Z. Laczkowski
Summary: The study synthesized novel carbazole dyes and analyzed the effects of activating and deactivating substituents on the chemical and biological properties of the compounds, revealing significant influences on the spectral, electrochemical, nonlinear-optic, and biological properties of the derivatives. The research also looked into the potential use of these derivatives as fluorescent probes for in vivo and in vitro tests, with quantum-chemical calculations complementing the conducted experiments.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Electrochemistry
Heydar Hameed Salman Arkwazee, Niloofar Mohamadighader, Davood Nematollahi, Arash Rabiee, Hojjat Alizadeh
Summary: This article describes a method for synthesizing new sulfonamide derivatives using electrochemical methods without toxic reagents, and finds that these products have good antibacterial performance against bacteria.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Electrochemistry
Anahita Daneshyar, Davood Nematollahi, Mahdi Bayat
Summary: 2-Amino-5-nitrophenol (ANP) is a compound of electrochemical interest, capable of synthesizing new sulfonamide-diarylsulfone (SDS) and diarylsulfone (DAS) derivatives through reduction/oxidation or single oxidation processes. Electrochemical synthesis of SDS was achieved under environmentally friendly conditions, while DAS synthesis was performed in a divided cell, both processes proposing mechanisms for the electrochemical behavior of ANP.
ELECTROCHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Parvaneh Amooshahi, Sadegh Khazalpour, Ameneh Amani, Hossein Masoumi
Summary: This study investigated the electrochemical behavior of mefenamic acid (MFA) in a water/ethanol mixture using various voltammetric techniques. The results showed that the oxidation of MFA is pH-dependent and follows the E-ir mechanism. The E-pA1-pH diagram revealed two linear segments with different slopes. The diffusion coefficient and surface excess of MFA in aqueous solution were determined, and the electrochemical nitration of MFA in the presence of nitrite ion was examined. The oxidized form of MFA was found to participate in a Michael-type addition reaction with nitrite ion to form nitromefenamic acids. Additionally, a computational study was performed to predict the nucleophilic addition pathway of nitrite ion. The electrochemical reduction of the nitromefenamic acids and the generation of two new azo derivatives were also investigated.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jia-Fei Poon, Luke A. Farmer, Evan A. Haidasz, Derek A. Pratt
Summary: The prediction of diarylamine radical-trapping antioxidant (RTA) activity at elevated temperatures is a challenge due to competing reactions. Phenoxazine, a superior RTA at ambient temperature, is shown to be inferior at elevated temperatures due to a lower reorganization energy barrier. Incorporating an electronegative N-atom into the phenoxazine ring system can rescue its activity, but further enhancements in reactivity for highly reactive diarylamines do not improve their efficacy in inhibiting hydrocarbon autoxidation at elevated temperatures.
Article
Chemistry, Organic
Olesja Koleda, Katrina Prane, Edgars Suna
Summary: The broad application of alpha,alpha-disubstituted cyclic amino acid derivatives in medicinal chemistry has prompted the need for the design of analogues with improved pharmacokinetic properties. In this study, we present an electrochemical approach for synthesizing unnatural THF- and THP-containing amino acid derivatives using anodic decarboxylation-intramolecular etherification of N-acetylamino malonic acid monoesters under Hofer-Moest reaction conditions. The decarboxylative cyclization occurs under constant current conditions in an undivided cell in an aqueous medium without the addition of any base.
Article
Chemistry, Medicinal
Oleg A. Tryapkin, Alexey V. Kantemirov, Sergey A. Dyshlovoy, Vladimir S. Prassolov, Pavel V. Spirin, Gunhild von Amsberg, Maria A. Sidorova, Maxim E. Zhidkov
Summary: Fascaplysin is a marine alkaloid that has diverse and potent biological activity, making it a promising lead drug candidate. It has the potential to be an effective anticancer agent due to its ability to inhibit CDK4 and induce intrinsic apoptosis in cancer cells. However, its high toxicity caused by DNA intercalation and the limited methods for synthesis of derivatives hinder the studies on structural optimization.
Article
Chemistry, Medicinal
Liubov Kozlovskaya, Viktor P. Volok, Anna A. Shtro, Yulia Nikolaeva, Alexey A. Chistov, Elena S. Matyugina, Evgeny S. Belyaev, Artjom Jegorov, Robert Snoeck, Vladimir A. Korshun, Graciela Andrei, Dmitry Osolodkin, Aydar A. Ishmukhametov, Andrey Aralov
Summary: Emerging and re-emerging viruses cause global outbreaks, highlighting the need for novel antivirals. Phenoxazine-based nucleoside analogs showed antiviral activity against 25 viruses, with some compounds inhibiting DNA/RNA viruses. Some phenoxazine derivatives exhibited promising inhibition against SARS-CoV-2, but with cytotoxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Corentin Maret, Nicolas David, David Pierrot, Eric Leonel, Vincent Levacher, Jean-Francois Briere, Sylvain Oudeyer
Summary: The electrocarboxylation of alpha,alpha-dichloroarylmethane derivatives in the presence of CO2 was achieved, resulting in the formation of alpha-chloroarylacetic acid derivatives with high selectivity. These derivatives were found to be versatile intermediates in synthetic chemistry and underwent various chemical transformations. A proposed mechanism was supported by control experiments and cyclic voltammetry.
Review
Energy & Fuels
Zhiya Han, Peng Wu, Mingyuan He, Xiaodong Zhuang, Hualin Lin, Sheng Han
Summary: Ammonia, a zero-carbon and high-energy storage feedstock, is primarily synthesized through the Haber-Bosch process, which has significant energy consumption and pollution concerns. The electrochemical nitrogen reduction reaction (ENRR) has emerged as a promising alternative method due to its environmental friendliness and ability to be carried out at room temperature and pressure. Researchers have been exploring various materials to improve the yield rates and Faradaic efficiency of ammonia production. Continued efforts in this field will likely lead to the industrialization of ENRR in the future.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Physical
Wojciech Baran, Ewa Masternak, Dominika Sapinska, Andrzej Sobczak, Ewa Adamek
Summary: The study found that under the photocatalytic action of TiO2, antibiotics underwent transformation to obtain new stable derivatives, including biologically active chlorine and bromine derivatives, as well as derivatives of antibiotics like Chloramphenicol and Amoxicillin. Additionally, potentially inactive halogen derivatives from Trimethoprim and hydroxyl derivatives described in the literature were also identified.
Article
Chemistry, Applied
Yuming Yu, Wei Lan, Xin Wang, Yaqiong Wang, Ming Gao, Xin Xu, Lei Shen, Dou Wang, Duozhi Wang, Ablimit Abdukader, Xiaodong Cai, Zhenjiang Liang, Hui Tan
Summary: In this study, two dibenzo[a,g]corannulene-phenoxazine dyads, BBC-C-PXZ and BBC-N-PXZ, were successfully synthesized and their photoelectrical properties were investigated. Both dyads showed intramolecular charge transfer in solution and aggregated state. They also exhibited moderate to good singlet oxygen quantum yields. The study provides new advances and breakthroughs in the design of organic electronic materials by introducing curved polycyclic aromatic hydrocarbons and diversified linkage positions.
