Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 9, Pages 1102-1105Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.1102
Keywords
Isodon lophanthoides var. gerardianus; diterpenoid; anti-hepatitis B virus
Funding
- NSFC-Joint Foundation of Yunnan Province [U0832602]
- Major Direction Projection Foundation of CAS [2010KIBA05]
- Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]
- Science and Technology Program of Yunnan Province [2008IF010, 2008CD162]
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Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
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