Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 6, Pages 770-772Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.770
Keywords
Inonotus hispidus; antioxidant; cytotoxicity; hispidin derivative
Funding
- National Natural Science Foundation of China [NSFC-30870013, NSFC-31000149]
- Ministry of Education of the People's Republic of China [NCET-09-0423]
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Two natural antioxidants, named inonotusin A (1) and B (2), were isolated from the methanolic extract of the fruit bodies of Inonotus hispidus, together with (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (3), hispidin (4) and 3,4-dihydroxybenzaldehyde (5). Their structures were identified by means of extensive NMR and MS data analysis. Compounds 1, 2 and 4 exhibited significant scavenging activity against the 2,20-azinobis(3-ethylbenzhiazoline-6-sulfonate) (ARTS) radical cation. Compound 1 also showed moderate cytotoxicity against a human breast carcinoma cell line (MCF-7) with IC50 values of 19.6 mu m.
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