Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 1, Pages 27-29Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.27
Keywords
carnosic acid; carnosol; synthesis; rosemary; anti-Propionibacterium acnes; anti-methicillin-resistant Staphylococcus aureus (MRSA)
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Carnosic acid (2), a major anti-oxidant in rosemary (Rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of Sawara (Chamaecyparis pisifera), via ortho-oxidation of the phenol using meta-chlorobenzoyl peroxide (mCBPO), chloroacetyl meta-chlorobenzoyl peroxide (CAMCBPO) or 2-iodoxybenzoic acid (IBX). Carnosol (3), another anti-oxidant in rosemary, was synthesized from carnosic acid by oxidation with silver oxide. Potent antibacterial activities against Propionibacterium acnes (ATCC 6919) (minimum inhibitory concentration (MIC) mu g/ml) and Staphylococcus aureus ME/GM/TC Resistant (ATCC 33592) (MIC mu g/ml) of carnosic acid and carnosol were reported.
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