Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 6, Pages 848-851Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.848
Keywords
Cespitularia hypotentaculata; verticillane diterpenoid; anti-inflammatory activity
Funding
- National Science Council of the Republic of China (Taiwan) [NSC96-2320-B-110-003-MY3]
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Chemical investigations of the Formosan soft coral Cespitularia hypotentaculata ROXAS led to the isolation of two new verticillane diterpenoids, cespitularins R and S (1, 2), along with seven known compounds (3-9). The structures of these isolated compounds were elucidated on the basis of extensive spectroscopic analysis and by comparison with those of reported in literature. The anti-inflammatory activity using RAW 264.7 macrophages of compounds 1-9 were evaluated in vitro.
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