4.3 Article

Cytotoxic constituents from the leaves of Cinnamomum subavenium

Journal

CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 1, Pages 97-101

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.97

Keywords

Cinnamomum subavenium; subamolide D; subamolide E; secosubamolide A

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Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1 - 3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that I and 2 caused DNA damage in a dose- and time-dependent manner.

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