Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 9, Pages 1276-1281Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1276
Keywords
Junceella juncea; junceol; briarane; cytotoxicity
Funding
- TCRC, NMMBA [97100107, 971001101]
- APORC, NSYSU [96C031702]
- NSTPBP, National Science Council [NSC 97-2323-B-291-001]
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Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D-H (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F-H (3-5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E-H (2-5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.
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