Article
Oncology
Yu Pan, Shunjie Xia, Jiaqin Cai, Ke Chen, Xiujun Cai
Summary: LH is safe and feasible for selected HCC patients with cirrhosis and provides better short-term and long-term outcomes in minor liver resection compared to OH. However, for major resection, LH may have longer operation time than OH. Further evidence is needed to support the use of laparoscopic major hepatectomy in cirrhotic patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Linye He, Zijing Xia, Xiaoyun Zhang, Zhihui Li, Tianfu Wen, Chuan Li
Summary: This study found that HBV-related HCC patients treated with consistent TDF therapy had a significantly lower risk of tumor recurrence than those treated with ETV after curative treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Oncology
Manon Falette Puisieux, Anna Pellat, Antoine Assaf, Claire Ginestet, Catherine Brezault, Marion Dhooge, Philippe Soyer, Romain Coriat
Summary: Hepatocellular carcinoma (HCC) is a major health problem and the fourth leading cause of cancer-related mortality worldwide. The prognosis for advanced HCC is poor, and the selection of optimal treatment remains a challenge. However, recent studies have shown that the combination of atezolizumab and bevacizumab can significantly improve survival and is recommended as the first-line treatment for advanced HCC. Other treatments, such as regorafenib and cabozantinib, can be considered for disease progression. Transarterial chemoembolization is also an alternative treatment for patients with intermediate-stage HCC. The accurate estimation of liver function is crucial for therapeutic management.
Article
Medical Laboratory Technology
Zhiying Liu, Hongtao Liu, Zhiji Chen, Chao Deng, Li Zhou, Siyuan Chen, Juan Kang, Yao Chen, Song He, Zhihang Zhou
Summary: In this study, potential plasma metabolite biomarkers of hepatocellular carcinoma (HCC) were identified and validated using gas chromatography-mass spectrometry. The combination of plasma N-formylglycine, oxoglutaric acid, citrulline, and heptaethylene glycol showed better diagnostic performance than alpha-fetoprotein (AFP). Additionally, this combination could effectively discriminate early stage HCC from cirrhosis. Moreover, heptaethylene glycol had inhibitory effects on the proliferation, migration, and invasion of HCC cells in vitro.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Ran Cheng, Xiaoyuan Xu
Summary: This study aimed to investigate the effectiveness of risk assessment models for hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related cirrhosis undergoing antiviral therapy. The results showed that the REAL-B score had a high prognostic capability in predicting HCC risk, and there were significant differences in HCC risk assessment between the intermediate-risk group and the high-risk group at 1, 3, and 5 years.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanyu Jiang, Yun Qin, Hong Wei, Tianying Zheng, Ting Yang, Yuanan Wu, Chengyu Ding, Victoria Chernyak, Maxime Ronot, Kathryn J. Fowler, Weixia Chen, Mustafa R. Bashir, Bin Song
Summary: This study investigated the value of MRI features in predicting the recurrence-free survival and overall survival of HCC patients. Tumor size, multiple tumors, rim arterial phase hyperenhancement, iron sparing, tumor growth pattern, and gastroesophageal varices were associated with both early recurrence-free survival and overall survival. Nonperipheral washout, markedly low apparent diffusion coefficient value, intratumoral arteries, and width of the main portal vein specifically predicted early recurrence-free survival, while the VICT2 trait specifically predicted overall survival. Multiple tumors and radiologically-evident cirrhosis were the only predictors for late recurrence-free survival.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jonggi Choi, Chanyoung Jo, Young-Suk Lim
Summary: This study compared HCC recurrence and survival in HBV-related HCC patients treated with TDF or ETV after surgical resection, finding that TDF therapy was associated with a significantly lower risk of HCC recurrence and better overall survival.
Article
Surgery
Yan-Yan Wang, Bang-De Xiang, Liang Ma, Jian-Hong Zhong, Jia-Zhou Ye, Kun Wang, Bao-Cai Xing, Le-Qun Li
Summary: The study developed a nomogram to estimate the risk of SPLD and long-term survival in HCC patients before hepatectomy. Independent preoperative predictors of SPLD were identified, including total bilirubin and albumin. The nomogram showed good performance in predicting both SPLD and overall survival, outperforming other existing algorithms.
Article
Surgery
Antonella Delvecchio, Maria Conticchio, Francesca Ratti, Maximiliano Gelli, Ferdinando Massimiliano Anelli, Alexis Laurent, Giulio Cesare Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola de'Angelis, Javier Briceno-Delgado, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: This study compared short-term and long-term outcomes between laparoscopic major hepatectomy (LMH) and open major hepatectomy (OMH) in elderly patients with HCC, showing that LMH had lower postoperative complications and shorter hospital stay compared to OMH, with comparable mortality rates at 90 days and overall survival rates at 1, 3, and 5 years. The study concluded that LMH is safe and feasible in elderly patients with HCC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Dingde Ye, Jiamu Qu, Jian Wang, Guoqiang Li, Beicheng Sun, Qingxiang Xu
Summary: This study aimed to develop a nomogram model to predict the overall survival probability of patients with hepatocellular carcinoma undergoing liver resection. The model showed good discriminative ability and calibration, with six risk factors included in the final model. The calibration between the model assessment and actual observations was found to be good, providing a valuable tool for evaluating patients' clinical outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jian Liu, Hao Shen, Shengyu Huang, Jianbo Lin, Zhenlin Yan, Guojun Qian, Zhenghua Lu, Xuying Wan, Fabiao Zhang, Kui Wang, Yongjie Zhang, Jun Li
Summary: This study observed the effect of antiviral therapy (AVT) on viral reactivation and long-term outcomes after percutaneous radiofrequency ablation (PRFA) for HBV-related HCC. The results showed that AVT can reduce the occurrence of viral reactivation, decrease distal intrahepatic recurrence and late recurrence after 2 years, and improve the overall survival of patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dongliang Zuo, Yuntong Li, Hongzhi Liu, Dongxu Liu, Qinliang Fang, Pengtao Li, Liang Tu, Yu Xiong, Yongyi Zeng, Pingguo Liu
Summary: The developed nomogram accurately predicts overall survival and disease-free survival for patients with large hepatocellular carcinoma, providing an effective strategy for hepatectomy treatment.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Iuliana Nenu, Horia Stefanescu, Bogdan Procopet, Zeno Sparchez, Iulia Minciuna, Tudor Mocan, Daniel Leucuta, Corina Morar, Mircea Grigorescu, Gabriela Adriana Filip, Carmen Socaciu
Summary: This study aims to identify new biomarkers for diagnosing HCC and assess the risk of tumor recurrence, decompensation, and cancer-related death. The results reveal that lipids play a crucial role in discriminating compensated cirrhosis and early hepatocellular carcinoma. Lipid metabolites could serve as markers of survival and prognosis in personalized and minimally invasive medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho
Summary: This study aimed to investigate the survival outcomes of antiviral agents in patients with hepatitis C virus who underwent liver resection for primary hepatocellular carcinoma. The results showed that antiviral treatment can prolong overall survival, and DAAs may have a protective effect against hepatic decompensation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Jae Hyun Kwon, Jung-Woo Lee, Jong Woo Lee, Young Joo Lee
Summary: This study compared the survival outcomes and recurrence rates of anatomical resection (AR) versus non-anatomical resection (NAR) in hepatocellular carcinoma (HCC) according to tumor size. The results showed that AR reduced the risk of tumor recurrence and improved overall survival in patients with HCCs smaller than 5 cm, while AR and NAR showed comparable survival outcomes in HCCs larger than 5 cm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yunfan Sun, Liang Wu, Yu Zhong, Kaiqian Zhou, Yong Hou, Zifei Wang, Zefan Zhang, Jiarui Xie, Chunqing Wang, Dandan Chen, Yaling Huang, Xiaochan Wei, Yinghong Shi, Zhikun Zhao, Yuehua Li, Ziwei Guo, Qichao Yu, Liqin Xu, Giacomo Volpe, Shuangjian Qiu, Jian Zhou, Carl Ward, Huichuan Sun, Ye Yin, Xun Xu, Xiangdong Wang, Miguel A. Esteban, Huanming Yang, Jian Wang, Michael Dean, Yaguang Zhang, Shiping Liu, Xinrong Yang, Jia Fan
Summary: This study showed that early-relapse hepatocellular carcinoma (HCC) tumors exhibit innate-like CD8(+) T cells with overexpression of KLRB1 (CD161) and a low cytotoxic state, unlike the exhausted state seen in primary HCC. These cells were associated with a worse prognosis. Additionally, potential immune evasion mechanisms were identified in recurrent tumor cells, which dampen dendritic cell antigen presentation and recruit innate-like CD8(+) T cells.
Article
Gastroenterology & Hepatology
Peng-Xiang Wang, Yang Xu, Yun-Fan Sun, Jian-Wen Cheng, Kai-Qian Zhou, Sui-Yi Wu, Bo Hu, Ze-Fan Zhang, Wei Guo, Ya Cao, Xiao-Wu Huang, Jian Zhou, Jia Fan, Xin-Rong Yang
Summary: This study investigated the value of circulating tumor cells (CTCs) as predictors of tumor recurrence following liver transplantation (LTx) in hepatocellular carcinoma (HCC) patients. Results showed that post-operative CTC count >= 1 per 5 mL blood could be a potential biomarker for predicting tumor recurrence, especially in patients with no detectable CTCs before LTx and negative tumor serological markers. Moreover, post-operative serial CTC detection may be useful in post-surgical surveillance for HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Peng-Xiang Wang, Yun-Fan Sun, Wei-Xiang Jin, Jian-Wen Cheng, Hai-Xiang Peng, Yang Xu, Kai-Qian Zhou, Li-Meng Chen, Kai Huang, Sui-Yi Wu, Bo Hu, Ze-Fan Zhang, Wei Guo, Ya Cao, Jian Zhou, Jia Fan, Xin-Rong Yang
Summary: The ChimeraX(R)-i120 platform successfully combines CTC detection with single-cell molecular analysis, demonstrating high sensitivity, accuracy, and reproducibility. High CTC-positive rates were found in five types of cancer, while CTCs were rarely detected in healthy donors. In hepatocellular carcinoma patients, CTC status was significantly associated with tumor characteristics, prognosis, and treatment response.
MOLECULAR ONCOLOGY
(2021)
Article
Surgery
Ruby Siu-Ting Lau, Philip Ip, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Eugene Jun-Yee Lo, Kandy Kam-Cheung Wong, Andrew Kai-Yip Fung, John Wong, Kit-Fai Lee, Kelvin Kwok-Chai Ng, Paul Bo-San Lai, Henry Lik-Yuen Chan, Charing Ching-Ning Chong
Summary: Preoperative liver stiffness measurement can predict late recurrence of hepatocellular carcinoma after curative resection.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Surgery
Kit Fai Lee, Charing Ching Ning Chong, John Wong, Sunny Yue Sun Cheung, Andrew Kai Yip Fung, Hon Ting Lok, Eugene Yee Juen Lo, Paul Bo San Lai
Summary: Robotic spleen preserving distal pancreatectomy has advantages of shorter operative time and hospital stay compared to robotic distal pancreatectomy with Splenectomy, and it also avoids the risk of overwhelming postsplenectomy sepsis.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Multidisciplinary Sciences
Yun-Fan Sun, Liang Wu, Shi-Ping Liu, Miao-Miao Jiang, Bo Hu, Kai-Qian Zhou, Wei Guo, Yang Xu, Yu Zhong, Xiao-Rui Zhou, Ze-Fan Zhang, Geng Liu, Sheng Liu, Ying-Hong Shi, Yuan Ji, Min Du, Nan-Nan Li, Gui-Bo Li, Zhi-Kun Zhao, Xiao-Yun Huang, Li-Qin Xu, Qi-Chao Yu, David H. Peng, Shuang-Jian Qiu, Hui-Chuan Sun, Michael Dean, Xiang-Dong Wang, Wen-Yuan Chung, Ashley R. Dennison, Jian Zhou, Yong Hou, Jia Fan, Xin-Rong Yang
Summary: This study used single-cell RNA sequencing to analyze circulating tumor cells from liver cancer patients, revealing that the transcriptional dynamics of CTCs are associated with stress response, cell cycle, and immune evasion signaling. Additionally, it was identified that CCL5 plays a crucial role in immune evasion of CTCs.
NATURE COMMUNICATIONS
(2021)
Article
Surgery
Janet W. C. Kung, Charing C. N. Chong, Kit-Fai Lee, John Wong, Paul B. S. Lai, Kelvin K. C. Ng
Summary: This novel technique of using the falciform ligament to fashion an interposition tube graft for reconstruction of IVC and HV has shown promising short-term outcomes, offering the benefits of autologous tissue graft with customizable dimensions.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2021)
Article
Computer Science, Interdisciplinary Applications
Xin Lai, Xiao Li, Liu Liu, Fugee Tsung, Paul B. S. Lai, Jiayin Wang, Xuanping Zhang, Xiaoyan Zhu, Jiaqi Liu
Summary: This study extends the risk-adjusted monitoring approach to include both average surgical risk changes and the existence of variance, leading to improved monitoring efficiency. Simulation results show that the proposed method is more efficient in detecting changes in surgical performance variance and small shifts in risk.
COMPUTERS & INDUSTRIAL ENGINEERING
(2021)
Editorial Material
Surgery
Paul B. S. Lai
Article
Gastroenterology & Hepatology
Alissa Michelle Wong, Xiaofan Ding, Aikha Melissa Wong, Mingjing Xu, Luyao Zhang, Howard Ho-Wai Leung, Anthony Wing-Hung Chan, Qi Xiu Song, Joseph Kwong, Loucia Kit-Ying Chan, Matthew Man, Mian He, Jinna Chen, Zhe Zhang, Wenxing You, Coleen Lau, Allen Yu, Yingying Wei, Yunfei Yuan, Paul Bo-San Lai, Jingmin Zhao, Kwan Man, Jun Yu, Michael Kahn, Nathalie Wong
Summary: The study revealed unique mutational processes in the livers of NAFLD-HCC patients, suggesting susceptibility to tumor formation through defective DNA repair pathways. CTNNB1 mutation plays a significant role in immune exclusion, providing important insights for the development of potential therapies.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Surgery
Paul B. S. Lai
Article
Surgery
Angela Y. W. Yuen, Justin C. Y. Chan, Man-Ping Luk, Kit-fai Lee, Tak-wing Lai, Paul B. S. Lai, Kelvin K. C. Ng, Charing C. N. Chong
Summary: This study evaluated the performance of a biodegradable pancreatic stent in pancreatoduodenectomy, with a high technical success rate and no hospital mortality, but some patients experienced complications such as post-operative pancreatic fistula.
Editorial Material
Surgery
Paul B. S. Lai
Editorial Material
Surgery
Paul B. S. Lai
Article
Immunology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, Myth T. S. Mok, Lingyun Zhang, Zhixian Liang, Xiaoyu Liu, Zhewen Xiong, Xuezhen Zeng, Jing Wang, Jiahuan Lu, Jingqing Li, Hanyong Sun, Xiaoyu Tian, Philip Chun Yeung, Yong Hou, Heung Man Lee, Candice C. H. Lam, Howard H. W. Leung, Anthony W. H. Chan, Ka Fai To, John Wong, Paul B. S. Lai, Kelvin K. C. Ng, Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)