Biological Applications of Expanded Genetic Codes

Evolution of Iron(II)-Finger Peptides by Using a Bipyridyl Amino Acid

(2014) Mingchao Kang et al.   CHEMBIOCHEM

Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness

(2014) Michael J Hammerling et al.   Nature Chemical Biology

Recoding the Genetic Code with Selenocysteine

(2013) Markus J. Bröcker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli

(2013) Abhishek Chatterjee et al.   BIOCHEMISTRY

Identification of metal ion binding peptides containing unnatural amino acids by phage display

(2013) Jonathan W. Day et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

(2013) Irene Coin et al.   CELL

Genetically Encoded Light-Activated Transcription for Spatiotemporal Control of Gene Expression and Gene Silencing in Mammalian Cells

(2013) James Hemphill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Genetically Encoded Fluorescent Probe in Mammalian Cells

(2013) Abhishek Chatterjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bispecific small molecule-antibody conjugate targeting prostate cancer

(2013) C. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the Limits of Genetic Recoding in Essential Genes

(2013) M. J. Lajoie et al.   SCIENCE

Genomically Recoded Organisms Expand Biological Functions

(2013) M. J. Lajoie et al.   SCIENCE

Expanding the Genetic Code of Caenorhabditis elegans Using Bacterial Aminoacyl-tRNA Synthetase/tRNA Pairs

(2012) Angela R. Parrish et al.   ACS Chemical Biology

Expanding the genetic code of Drosophila melanogaster

(2012) Ambra Bianco et al.   Nature Chemical Biology

Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli

(2012) A. Chatterjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid

(2011) Hui-wang Ai et al.   CHEMBIOCHEM

Subcellular Protein Localization by Using a Genetically Encoded Fluorescent Amino Acid

(2011) Godefroid Charbon et al.   CHEMBIOCHEM

Reprogramming the genetic code

(2011) Jason W Chin   EMBO JOURNAL

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin

(2011) Mariano Oppikofer et al.   EMBO JOURNAL

Site-Specific Coupling and Sterically Controlled Formation of Multimeric Antibody Fab Fragments with Unnatural Amino Acids

(2011) Benjamin M. Hutchins et al.   JOURNAL OF MOLECULAR BIOLOGY

Traceless and Site-Specific Ubiquitination of Recombinant Proteins

(2011) Satpal Virdee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells

(2011) Arnaud Gautier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the Genetic Code of an Animal

(2011) Sebastian Greiss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of transcription by unnatural amino acids

(2011) Chang C Liu et al.   NATURE BIOTECHNOLOGY

RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

(2011) David B F Johnson et al.   Nature Chemical Biology

A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance

(2011) Meng Zhang et al.   Nature Chemical Biology

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

(2011) E. Arbely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimized clinical performance of growth hormone with an expanded genetic code

(2011) H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the Genetic Code of Escherichia coli with Phosphoserine

(2011) H.-S. Park et al.   SCIENCE

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

(2011) Farren J. Isaacs et al.   SCIENCE

Genetically Encoding Unnatural Amino Acids in Neural Stem Cells and Optically Reporting Voltage-Sensitive Domain Changes in Differentiated Neurons

(2011) Bin Shen et al.   STEM CELLS

In Vivo Double and Triple Labeling of Proteins Using Synthetic Amino Acids

(2010) Sandra Lepthien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Strategy to Photoactivate Green Fluorescent Protein

(2010) Dan Groff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Facile System for Genetic Incorporation of Two Different Noncanonical Amino Acids into One Protein inEscherichia coli

(2010) Wei Wan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

A Genetically Encoded ε-N-Methyl Lysine in Mammalian Cells

(2010) Dan Groff  et al.   CHEMBIOCHEM

A method to site-specifically introduce methyllysine into proteins in E. coli

(2010) Hui-wang Ai et al.   CHEMICAL COMMUNICATIONS

Genetically Directing ɛ-N, N-Dimethyl-l-Lysine in Recombinant Histones

(2010) Duy P. Nguyen et al.   CHEMISTRY & BIOLOGY

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair

(2010) Susan M. Hancock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoded Photocontrol of Protein Localization in Mammalian Cells

(2010) Arnaud Gautier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De NovoGeneration of Mutually Orthogonal Aminoacyl-tRNA Synthetase/tRNA Pairs

(2010) Heinz Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genetically encoded photocaged Nε-methyl-l-lysine

(2010) Yane-Shih Wang et al.   Molecular BioSystems

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein

(2010) Shunsuke Tagami et al.   NATURE

Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization

(2010) Michael Lammers et al.   Nature Chemical Biology

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

(2010) Satpal Virdee et al.   Nature Chemical Biology

Expansion of the genetic code: Site-directed p-fluoro-phenylalanine incorporation in Escherichia coli

(2010) Rolf Furter   PROTEIN SCIENCE

Genetically encoding an aliphatic diazirine for protein photocrosslinking

(2010) Chungjung Chou et al.   Chemical Science

A Facile System for Encoding Unnatural Amino Acids in Mammalian Cells

(2009) Peng R. Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutagenesis and Evolution of Sulfated Antibodies Using an Expanded Genetic Code

(2009) Chang C. Liu et al.   BIOCHEMISTRY

Photocleavage of the Polypeptide Backbone by 2-Nitrophenylalanine

(2009) Francis B. Peters et al.   CHEMISTRY & BIOLOGY

Genetically EncodingNϵ-Methyl-l-lysine in Recombinant Histones

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of Proteins with Genetically Encoded “Chemical Warheads”

(2009) Chang C. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Incorporation of a Small, Environmentally Sensitive, Fluorescent Probe into Proteins inSaccharomyces cerevisiae

(2009) Hyun Soo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Plasticity of a Translation Arrest Motif Yields Insights into Nascent Polypeptide Recognition inside the Ribosome Tunnel

(2009) Mee-Ngan Yap et al.   MOLECULAR CELL

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

(2009) Heinz Neumann et al.   MOLECULAR CELL

Next-generation synthetic gene networks

(2009) Timothy K Lu et al.   NATURE BIOTECHNOLOGY

Toward scalable parts families for predictable design of biological circuits

(2008) Julius B Lucks et al.   CURRENT OPINION IN MICROBIOLOGY

A Mutual Inhibition between APC/C and Its Substrate Mes1 Required for Meiotic Progression in Fission Yeast

(2008) Yuu Kimata et al.   DEVELOPMENTAL CELL

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

Protein evolution with an expanded genetic code

(2008) C. C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA