Enhancing the Efficiency and Regioselectivity of P450 Oxidation Catalysts by Unnatural Amino Acid Mutagenesis

Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C—H Functionalization

(2013) Joshua N. Kolev et al.   ACS Chemical Biology

Controlling Site Selectivity in Palladium-Catalyzed C–H Bond Functionalization

(2012) Sharon R. Neufeldt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Catalytic, Mild, and Selective Oxyfunctionalization of Linear Alkanes: Current Challenges

(2012) Mélanie Bordeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

(2012) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Regioselective Biocatalyst for Alkane Activation under Mild Conditions

(2011) Mélanie Bordeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

If CH Bonds Could Talk: Selective CH Bond Oxidation

(2011) Timothy Newhouse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

(2011) V. Rea et al.   BIOCHEMISTRY

Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites

(2011) Anna Gliszczyńska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

(2011) Maragani Satyanarayana et al.   CHEMICAL COMMUNICATIONS

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity

(2011) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

(2011) Sabrina Kille et al.   Nature Chemistry

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

(2010) Jared C. Lewis et al.   CHEMBIOCHEM

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes

(2010) Evelyne Weber et al.   CHEMICAL COMMUNICATIONS

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

(2010) Jeremiah A Johnson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Two-dimensional NMR and All-atom Molecular Dynamics of Cytochrome P450 CYP119 Reveal Hidden Conformational Substates

(2010) Jed N. Lampe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving a Natural Enzyme Activity through Incorporation of Unnatural Amino Acids

(2010) Isaac N. Ugwumba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efforts Toward the Direct Experimental Characterization of Enzyme Microenvironments: Tyrosine100 in Dihydrofolate Reductase

(2009) Dan Groff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme

(2009) Aélig Robin et al.   CHEMICAL COMMUNICATIONS

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

(2009) Sason Shaik et al.   CHEMICAL REVIEWS

Enhancing the utility of unnatural amino acid synthetases by manipulating broad substrate specificity

(2009) Audrey L. Stokes et al.   Molecular BioSystems

Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine

(2009) C. Aldag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

(2009) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary History of a Specialized P450 Propane Monooxygenase

(2008) Rudi Fasan et al.   JOURNAL OF MOLECULAR BIOLOGY

Ligand-Induced Conformational Heterogeneity of Cytochrome P450 CYP119 Identified by 2D NMR Spectroscopy with the Unnatural Amino Acid13C-p-Methoxyphenylalanine

(2008) Jed N. Lampe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology