Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily

Enhancement of the Promiscuous Aldolase and Dehydration Activities of 4-Oxalocrotonate Tautomerase by Protein Engineering

(2012) Ellen Zandvoort et al.   CHEMBIOCHEM

Dehalogenation of an Anthropogenic Compound by an Engineered Variant of the Mouse Cytokine Macrophage Migration Inhibitory Factor

(2012) Anna A. Wasiel et al.   CHEMBIOCHEM

Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase

(2011) Ellen Zandvoort et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of a Newly Identified Mycobacterial Tautomerase with Promiscuous Dehalogenase and Hydratase Activities Reveals a Functional Link to a Recently Divergedcis-3-Chloroacrylic Acid Dehalogenase

(2011) Bert-Jan Baas et al.   BIOCHEMISTRY

Role of Chemistry versus Substrate Binding in Recruiting Promiscuous Enzyme Functions

(2011) Olga Khersonsky et al.   BIOCHEMISTRY

Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity

(2011) Ellen Zandvoort et al.   CHEMBIOCHEM

Reaction of cis-3-Chloroacrylic Acid Dehalogenase with an Allene Substrate, 2,3-Butadienoate: Hydration via an Enamine

(2011) Gottfried K. Schroeder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

What makes an enzyme promiscuous?

(2010) Ann Babtie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families ofcis,cis-Muconate Lactonizing Enzymes†‡

(2009) Ayano Sakai et al.   BIOCHEMISTRY

Structural and mechanistic analysis oftrans-3-chloroacrylic acid dehalogenase activity

(2008) Scott D. Pegan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of Cg10062 fromCorynebacterium glutamicum: Implications for the Evolution ofcis-3-Chloroacrylic Acid Dehalogenase Activity in the Tautomerase Superfamily†

(2008) Gerrit J. Poelarends et al.   BIOCHEMISTRY

The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily

(2008) G. J. Poelarends et al.   CELLULAR AND MOLECULAR LIFE SCIENCES