Evolutionary Imprint of Catalytic Domains in Fungal PKS-NRPS Hybrids

Biosynthesis of Xyrrolin, a New Cytotoxic Hybrid Polyketide/Non-ribosomal Peptide Pyrroline with Anticancer Potential, in Xylaria sp. BCC 1067

(2012) Suranat Phonghanpot et al.   CHEMBIOCHEM

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis

(2012) B. D. Ames et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifactorial Induction of an Orphan PKS-NRPS Gene Cluster in Aspergillus terreus

(2011) Markus Gressler et al.   CHEMISTRY & BIOLOGY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double Oxidation of the Cyclic Nonaketide Dihydromonacolin L to Monacolin J by a Single Cytochrome P450 Monooxygenase, LovA

(2011) Jorge Barriuso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

(2011) Kangjian Qiao et al.   METABOLIC ENGINEERING

Functional analysis of non-ribosomal peptide synthetases (NRPSs) in Trichoderma virens reveals a polyketide synthase (PKS)/NRPS hybrid enzyme involved in the induced systemic resistance response in maize

(2011) P. K. Mukherjee et al.   MICROBIOLOGY-SGM

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

(2011) H.-W. Nutzmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides

(2011) Mary N. Heneghan et al.   Chemical Science

Identification of a hybrid PKS–NRPS required for the biosynthesis of NG-391 in Metarhizium robertsii

(2010) Bruno Giuliano Garisto Donzelli et al.   CURRENT GENETICS

Aspergillus fumigatus Catalytic Glucokinase and Hexokinase: Expression Analysis and Importance for Germination, Growth, and Conidiation

(2010) Christian B. Fleck et al.   EUKARYOTIC CELL

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and inSaccharomyces cerevisiae

(2010) Wei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chemistry and biology of cytochalasans

(2010) Kirstin Scherlach et al.   NATURAL PRODUCT REPORTS

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Functional expression of the Aspergillus flavus PKS–NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid

(2009) Yasuyo Seshime et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

(2009) T. Verne Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Bioluminescent Aspergillus fumigatus, a New Tool for Drug Efficiency Testing and In Vivo Monitoring of Invasive Aspergillosis

(2008) M. Brock et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

EPoS: a modular software framework for phylogenetic analysis

(2008) T. Griebel et al.   BIOINFORMATICS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Identification of a novel polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae

(2008) Masafumi Tokuoka et al.   FUNGAL GENETICS AND BIOLOGY

Thioesterase-Like Role for Fungal PKS-NRPS Hybrid Reductive Domains

(2008) James W. Sims et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Improved General Amino Acid Replacement Matrix

(2008) S. Q. Le et al.   MOLECULAR BIOLOGY AND EVOLUTION

Magnaporthe griseaavirulence geneACE1belongs to an infection-specific gene cluster involved in secondary metabolism

(2008) Jérôme Collemare et al.   NEW PHYTOLOGIST

Biosynthesis of secondary metabolites in the rice blast fungus Magnaporthe grisea: the role of hybrid PKS-NRPS in pathogenicity

(2007) Jérôme Collemare et al.