In silico assessment of drug safety in human heart applied to late sodium current blockers

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing

(2012) Gary R Mirams et al.   BRITISH JOURNAL OF PHARMACOLOGY

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

(2012) Nejib Zemzemi et al.   BRITISH JOURNAL OF PHARMACOLOGY

In Silico Cardiac Risk Assessment in Patients With Long QT Syndrome

(2012) Ryan Hoefen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

(2012) Beatriz Trenor et al.   PLoS One

The comparative sensitivity of three in vitro safety pharmacology models for the detection of lidocaine-induced cardiac effects

(2012) Sonia Goineau et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Mechanisms of atrial-selective block of Na+ channels by ranolazine: I. Experimental analysis of the use-dependent block

(2011) Andrew C. Zygmunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of atrial-selective block of Na+ channels by ranolazine: II. Insights from a mathematical model

(2011) Vladislav V. Nesterenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species

(2011) Thomas O'Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of I Kr Inhibition on Ventricular Repolarization

(2011) Lin Wu et al.   CIRCULATION

Mechanism of Reverse Rate-Dependent Action of Cardioactive Agents

(2011) T. Banyasz et al.   CURRENT MEDICINAL CHEMISTRY

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Late Phase of Repolarization is Autoregenerative and Scales Linearly with Action Potential Duration in Mammals Ventricular Myocytes: A Model Study

(2011) M. Zaniboni   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity

(2011) Cristian Obiol-Pardo et al.   Journal of Chemical Information and Modeling

3D current–voltage–time surfaces unveil critical repolarization differences underlying similar cardiac action potentials: A model study

(2011) M. Zaniboni   MATHEMATICAL BIOSCIENCES

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

(2011) T.A. Quinn et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKrblockade

(2010) Shaobin Jia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle

(2010) Alexey V. Glukhov et al.   CIRCULATION RESEARCH

How different two almost identical action potentials can be: A model study on cardiac repolarization

(2010) Massimiliano Zaniboni et al.   MATHEMATICAL BIOSCIENCES

Characterization of cardiac repolarization in the Göttingen minipig

(2010) Morten Laursen et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Electrotonic Coupling between Human Atrial Myocytes and Fibroblasts Alters Myocyte Excitability and Repolarization

(2009) Mary M. Maleckar et al.   BIOPHYSICAL JOURNAL

Use-dependent block of cardiac late Na+ current by ranolazine

(2009) Sridharan Rajamani et al.   HEART RHYTHM

Rapid Kinetic Interactions of Ranolazine With HERG K+ Current

(2009) Sridharan Rajamani et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

(2009) J. R. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cardiac Physiome: perspectives for the future

(2008) James Bassingthwaighte et al.   EXPERIMENTAL PHYSIOLOGY

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

(2008) Lin Wu et al.   HEART RHYTHM

Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

(2008) Peter Milberg et al.   HEART RHYTHM

Antiarrhythmic effect of IKr activation in a cellular model of LQT3

(2008) Jonas Goldin Diness et al.   HEART RHYTHM

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type-3 Long-QT Syndrome

(2008) ARTHUR J. MOSS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

In silico risk assessment for drug-induction of cardiac arrhythmia

(2008) Shingo Suzuki et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The cardiac persistent sodium current: an appealing therapeutic target?

(2007) D A Saint   BRITISH JOURNAL OF PHARMACOLOGY

Peroxynitrite formation mediates LPC-induced augmentation of cardiac late sodium currents

(2007) Mathieu Gautier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Contributions of HERG K+ current to repolarization of the human ventricular action potential

(2007) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY