Article
Neurosciences
Arena Manning, Victor Han, Alexa Stephens, Rose Wang, Nicholas Bush, Michelle Bard, Jan M. Ramirez, Franck Kalume
Summary: Mutations in the NDUFS4 gene can lead to Leigh syndrome (LS), the most common form of mitochondrial disease in children. Epileptic seizures, which are difficult to treat and indicate poor prognosis, are a significant clinical feature of LS. By studying the effects of Ndufs4 gene mutations in GABAergic interneurons of mice, we gain insights into the epilepsy phenotype of LS and the cellular mechanisms underlying epilepsy in LS and other mitochondrial diseases.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Alexandra V. Griflyuk, Tatyana Y. Postnikova, Sergey L. Malkin, Aleksey V. Zaitsev
Summary: Febrile seizures during early childhood can cause central nervous system developmental disorders. The specific mechanisms of how febrile seizures affect the developing brain are not well understood. In this study, we used a hyperthermic model of febrile seizures in 10-day-old rats and tracked their development for two months. Our findings suggest that febrile seizures reduce the number of neurons in various regions of the hippocampus and impair glutamatergic transmission, leading to decreased local field potential amplitude.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Paolo Scalmani, Rosina Paterra, Massimo Mantegazza, Massimo Avoli, Marco de Curtis
Summary: Single-unit recordings in temporal lobe epilepsy patients and models of temporal lobe seizures showed that interneurons are active during focal seizure onset. This study performed simultaneous patch-clamp and field potential recordings in entorhinal cortex slices of mice to analyze the activity of specific interneuron (IN) subpopulations during acute seizure-like events (SLEs) induced by 4-aminopyridine (4-AP). The results revealed that entorhinal cortex INs are highly active at the onset and during the progression of 4-AP-induced SLEs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Sam A. Booker, Anna Sumera, Peter C. Kind, David J. A. Wyllie
Summary: The study found that the contribution of GluN2A subunits to glutamatergic synaptic currents varies among different subclasses of interneurons in the CA1 region of the hippocampus. GluN2A contributes to EPSC in parvalbumin-positive and somatostatin-positive interneurons, while its contribution is negligible in cholecystokinin (CCK)-positive interneurons. Furthermore, synaptic potentiation at glutamatergic synapses on CCK-positive interneurons does not require the activation of GluN2A-containing NMDARs but does rely on the activation of NMDARs containing GluN2B and GluN2D subunits.
Article
Neurosciences
Priyodarshan Goswamee, Elizabeth Leggett, A. Rory McQuiston
Summary: The study demonstrates that optogenetic stimulation of reuniens afferents can mediate both excitation and inhibition of CA1 principal cells, and recruit distinct subpopulations of local GABAergic interneurons in CA1 to modulate neuronal activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
You Yi, Chen Zhong, Hu Wei-wei
Summary: Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. They are common in young children, with a prevalence of up to 4% in children aged 6 months to 5 years old. FSs can have detrimental effects on neurodevelopment, leading to ADHD, increased susceptibility to epilepsy, hippocampal sclerosis, and cognitive decline in adulthood. However, the underlying mechanisms of these developmental abnormalities and disease occurrence have not yet been determined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Jia Li, Si-Mei Lin, Jing-Da Qiao, Xiao-Rong Liu, Jie Wang, Mi Jiang, Jing Zhang, Min Zhong, Xu-Qin Chen, Jing Zhu, Na He, Tao Su, Yi-Wu Shi, Yong-Hong Yi, Wei-Ping Liao
Summary: This study identified CELSR3 gene variants potentially associated with FS/EFS+, leading to impaired protein function, but patients had favorable outcomes without neurodevelopmental disorders.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Veronika Bodi, Timea Majer, Viktor Kelemen, Ildiko Vilagi, Attila Szucs, Petra Varro
Summary: ASD is considered as one of the main causes of neurodevelopmental disorders characterized by impairments in social interactions and repetitive behavior. Prenatal VPA treatment has diverse effects on hippocampal excitability depending on the sex and age of the animals, with differences in excitability observed in male and female rats of different age groups.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Neurosciences
Yang Tian, Qiong-Xiang Zhai, Xiao-Jing Li, Zhen Shi, Chuan-Fang Cheng, Cui-Xia Fan, Bin Tang, Ying Zhang, Yun-Yan He, Wen-Bin Li, Sheng Luo, Chi Hou, Wen-Xiong Chen, Wei-Ping Liao, Jie Wang
Summary: This study identified ATP6V0C gene mutations associated with febrile seizures (FS) and epilepsy with febrile seizures plus (EFS+). These mutations may affect the protein function and lead to afebrile seizures. Screening for ATP6V0C mutations can differentiate patients from other related diseases such as Dravet syndrome.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Svetlana Gataullina, Gilles Galvani, Sabrina Touchet, Caroline Nous, Eric Lemaire, Jacques Laschet, Catherine Chiron, Olivier Dulac, Elena Dossi, Jean-Daniel Brion, Samir Messaoudi, Mouad Alami, Gilles Huberfeld
Summary: This study aims to find a drug target for the treatment of early-onset epilepsies. The research suggests that abnormal upregulation of specific NMDA receptor subunits in neurons may contribute to the development of early-onset epilepsies. By developing and screening compounds, researchers identified a compound that can pass through the blood-brain barrier and effectively inhibit NMDA currents. Testing on mice and human brain samples showed that this compound has anti-epileptic activity.
Article
Clinical Neurology
Kevin D. Chen, Alicia M. Hall, Megan M. Garcia-Curran, Gissell A. Sanchez, Jennifer Daglian, Renhao Luo, Tallie Z. Baram
Summary: The study successfully induced eFSE in mice and found that eFSE increased susceptibility to the epileptic agent KA in adult mice, leading to shortened latency to seizure onset and increased severity. 16.5% of the mice developed epilepsy after experiencing eFSE, suggesting that eFSE promotes pro-epileptogenic network changes in some mice, resembling temporal lobe epilepsy.
Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Alexandra Griflyuk, Dmitry Amakhin, Anna A. Kovalenko, Elena B. Soboleva, Olga E. Zubareva, Aleksey Zaitsev
Summary: Febrile seizures in early life can cause slight morphological disturbances in the hippocampus, but lead to significant functional impairments, particularly in the activity of NMDARs and LTP in synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Shaoping Zhong, Zhihao Zhao, Wanjing Xie, Yiying Cai, Yiying Zhang, Jing Ding, Xin Wang
Summary: This study confirmed a profound disturbance in GABAergic interneurons and synaptic transmission in patients with type II FCD, which is related to the activation status of mTOR. Postnatal mTOR inhibition can partially rescue this disturbance. The results also suggest that postsynaptic mechanisms independent of interneuron reduction or altered expression of GABA synapse genes might be responsible for the impaired GABAergic neurotransmission in type II FCD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Noemi Binini, Francesca Talpo, Paolo Spaiardi, Claudia Maniezzi, Matteo Pedrazzoli, Francesca Raffin, Niccolo Mattiello, Antonio N. Castagno, Sergio Masetto, Yuchio Yanagawa, Clayton T. Dickson, Stefano Ramat, Mauro Toselli, Gerardo Rosario Biella
Summary: The perirhinal cortex (PRC) acts as a gateway between cortical areas and hippocampus, with its neurons being able to amplify output signals and coordinate network activity in the brain through resonance. This resonance ability is crucial for information transmission and memory enhancement between neocortex and hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Dmitry Amakhin, Elena B. Soboleva, Tatiana Yu Postnikova, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Daria S. Kalinina, Dmitrii S. Vasilev, Aleksey Zaitsev
Summary: This study investigated the long-term effects of prenatal hypoxia on the properties of pyramidal neurons in the hippocampus and entorhinal cortex. The results showed increased cell loss in the entorhinal cortex and altered electrophysiological characteristics in both the entorhinal cortex and hippocampus. These findings suggest that prenatal hypoxia may lead to increased excitability in neuronal circuits in the brain of young rats.
FRONTIERS IN NEUROSCIENCE
(2022)