The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels

Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied effectors of heterotrimeric G proteins in general and G beta gamma subunits in particular. However, our understanding of the roles of multiple G beta gamma binding sites on Kir3 channels is still rudimentary. We discuss potential roles for G beta gamma in channel assembly and trafficking in addition to their known role in cellular signaling.