Article
Immunology
Kanika Verma, Rahul Shukla, Jaya Dwivedi, Sarvesh Paliwal, Swapnil Sharma
Summary: Simvastatin has vasorelaxant activity, which involves NO/cGMP pathways, AT(2)R receptors, Ca2+ channels, and K+ channels.
INFLAMMOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marbella Quinonez, Marino DiFranco, Fenfen Wu, Stephen C. Cannon
Summary: Recurrent episodes of weakness in periodic paralysis are caused by intermittent loss of muscle fibre excitability. Retigabine, a potassium channel opener, can prevent the episodic loss of force and enhance recovery in mouse models of HypoPP. The protection and rescue effects of retigabine are well within the therapeutic window.
Article
Biology
Su Mi Park, Cooper E. Roache, Philip H. Iffland II, Hans J. Moldenhauer, Katia K. Matychak, Amber E. Plante, Abby G. Lieberman, Peter B. Crino, Andrea Meredith
Summary: This study evaluates the clinical significance of KCNMA1 mutations and the clinical heterogeneity of PNKD3, and establishes the relative pathogenic potential of patient alleles. The results indicate that certain KCNMA1 mutations can lead to neuronal hyperexcitability and seizure propensity.
Article
Physics, Multidisciplinary
Hillel Ori, Marc Duque, Rebecca Frank Hayward, Colin Scheibner, He Tian, Gloria Ortiz, Vincenzo Vitelli, Adam E. Cohen
Summary: The interface between two tissues can exhibit electrical excitability due to the interaction between currents passing through gap junctions and the non-linear current-voltage dependency in ion channels. This excitability occurs over a wider range of ion channel expression levels than bulk excitability. The interfacial action potentials can lead to local calcium concentration changes, potentially serving as a bioelectrical mechanism for interface sensing.
Article
Multidisciplinary Sciences
Junichi Ozawa, Seiko Ohno, Dario Melgari, Qi Wang, Megumi Fukuyama, Futoshi Toyoda, Takeru Makiyama, Masao Yoshinaga, Hiroshi Suzuki, Akihiko Saitoh, Tomohiko Ai, Minoru Horie
Summary: Timothy syndrome (TS) is a rare disorder associated with long QT syndrome, syndactyly, dysmorphic features, and neurological symptoms. This study identified a novel CACNA1C variant, p.R412M, in an atypical TS case. Functional analysis showed that p.R412M caused late Ca2+ currents and delayed Ca(V)1.2 channel inactivation, similar to the underlying mechanisms of classical TS.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Paolo Zuccolini, Loretta Ferrera, Alessia Remigante, Cristiana Picco, Raffaella Barbieri, Sara Bertelli, Oscar Moran, Paola Gavazzo, Michael Pusch
Summary: This research investigated the effect of DCPIB on pancreatic duct adenocarcinoma (PDAC) and melanoma and found that DCPIB directly targeted BK channels and increased intracellular Ca2+ levels. These findings are important for the development of DCPIB-based modulators of ion channels and membrane proteins in the future.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Szilvia Deri, Teodora Hartai, Laszlo Virag, Norbert Jost, Alain J. Labro, Andras Varro, Istvan Baczko, Stanley Nattel, Balazs Ordog
Summary: This study found that the candidate regulatory subunit KCNE3 of the I-Ks ion channel minimizes the inhibitory effects of LQT5 KCNE1 variants on I-Ks amplitudes and accelerates current deactivation. KCNE3 achieves this by displacing the KCNE1 subunit within the I-Ks ion channel complex.
Review
Medicine, Research & Experimental
Xinai Zhang, Yuqian Gao, Yutong Zhou, Zhiming Liu, Ruxiu Liu
Summary: Arrhythmia, characterized by abnormal heartbeat rhythms and frequencies, is the leading cause of death in patients with cardiovascular disease, posing a serious risk to human health. Natural drugs and their active ingredients, such as matrine, tetrandrine, and ginsenosides, have been widely used in the treatment of arrhythmia-like diseases due to their unique advantages. This review summarizes the mechanism of action of natural drugs in the treatment of arrhythmia by regulating Ca2+ levels, providing ideas for the innovative development of natural drugs with potential antiarrhythmic efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Kajol Shah, Sarah Seeley, Castin Schulz, Jacqueline Fisher, Shubha Gururaja Rao
Summary: Calcium ions are crucial for cell signaling and participate in various physiological functions. Mutations and dysfunctions of calcium channels in the heart can cause diseases and disorders. Drugs targeting calcium channels are used for the treatment of cardiac disorders.
Article
Multidisciplinary Sciences
Jade L. Taylor, Harry A. T. Pritchard, Katy R. Walsh, Patrick Strangward, Claire White, David Hill-Eubanks, Mariam Alakrawi, Grant W. Hennig, Stuart M. Allan, Mark T. Nelson, Adam S. Greenstein
Summary: The study investigates the role of vasodilatory pathways in cerebral arteries in the context of Alzheimer's disease. The researchers found that dysfunction in potassium channels involved in vasodilation may contribute to reduced blood flow and impaired functional hyperemia, highlighting the importance of targeting these pathways for potential therapeutic interventions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Hong T. L. Phan, Hyun J. Kim, Sungwoo Jo, Woo K. Kim, Wan Namkung, Joo H. Nam
Summary: Calcium signaling in T-lymphocytes is regulated by ORAI1 and potassium channels, and Licochalcone A effectively inhibits these channels to suppress T-cell activation and proliferation, making it a potential treatment for inflammation-related immune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jan-Luca Stampf, Cosmin I. Ciotu, Stefan Heber, Stefan Boehm, Michael J. M. Fischer, Isabella Salzer
Summary: The mechanism of acetaminophen (APAP) analgesia is not fully understood. In this study, it was found that the APAP metabolite N-acetyl-p-benzoquinone imine (NAPQI) activates Kv7 channels in neurons, leading to a decrease in neuronal firing. The Kv7 channel blocker XE991 was shown to reduce the analgesic effect of APAP on mechanical pain in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Uma Mahesh R. Avula, Lea Melki, Jared S. Kushner, Stephanie Liang, Elaine Y. Wan
Summary: Reentrant cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF) are common and can lead to substantial morbidity and mortality worldwide. The study using a mouse model with AF and VF identified regional heterogeneity of action potential duration (APD) in the heart as key drivers for reentry initiation and persistence. Discussing theoretical patterns of dispersion, demonstrating patterns seen in the mouse model, and analyzing APD dispersion patterns computationally may improve understanding and aid in developing risk stratification and treatment strategies for arrhythmias.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jia Liu, Nishanth Ganeshbabu, Noha Shalaby, Longtu Chen, Tiantian Guo, Bin Feng
Summary: Recent reports suggest that TRAAK and TREK-1 channels play important roles in action potential repolarization in mammalian peripheral nerves. A new in vitro approach was developed to study the effects of mechanical stretch on nerve conduction, showing that axial stretch leads to increased conduction delay in both myelinated A-fibers and unmyelinated C-fibers. These results highlight the potential for pharmacological and mechanical activation of K2P channels in modulating peripheral nerve function.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Xue An, Jiwon Lee, Ga Hye Kim, Hyun-Ji Kim, Hyun-Jeong Pyo, Ilmin Kwon, Hana Cho
Summary: Recent studies have shown that PRMT1 is highly expressed in the human heart, and loss of PRMT1 contributes to cardiac remodeling in heart failure. This study demonstrates the critical role of PRMT1 in regulating the I-Ks channel and cardiac rhythm.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Anne C. Teilmann, Morten B. Thomsen, Elizabeth A. Ihms, Nathan Pate, Jann Hau, Klas Abelson
LABORATORY ANIMALS
(2018)
Meeting Abstract
Endocrinology & Metabolism
Louise Thisted, Ross T. Lindsay, Keld Fosgerau, Thomas Secher, Morten B. Thomsen, Thomas Jespersen, Andrew J. Murray, Philip J. Pedersen, Niels Vrang, Lisbeth N. Fink, Tanja X. Pedersen, Nora E. Zois
Article
Cardiac & Cardiovascular Systems
Kirstine Calloe, Anders K. Broendberg, Alex H. Christensen, Lisbeth N. Pedersen, Morten S. Olesen, Maria de los Angeles Tejada, Soren Friis, Morten B. Thomsen, Henning Bundgaard, Henrik K. Jensen
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Anniek F. Lubberding, Morten B. Thomsen
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2019)
Article
Physiology
Anniek F. Lubberding, Laetitia Pereira, Jianbin Xue, Lisa A. Gottlieb, Vladimir V. Matchkov, Ana M. Gomez, Morten B. Thomsen
Article
Hematology
Jennifer van der Horst, Rian W. Manville, Katie Hayes, Morten B. Thomsen, Geoffrey W. Abbott, Thomas A. Jepps
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Editorial Material
Physiology
Josephine C. Adams, P. Darwin Bell, Sue C. Bodine, Heddwen L. Brooks, Nigel Bunnett, Bina Joe, Kara Hansell Keehan, Thomas R. Kleyman, Andre Marette, Rory E. Morty, Jan-Marino Ramirez, Morten B. Thomsen, Bill J. Yates, Irving H. Zucker
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Louise Thisted, Mette Ostergaard, Annemarie A. Pedersen, Philip J. Pedersen, Ross T. Lindsay, Andrew J. Murray, Lisbeth N. Fink, Tanja X. Pedersen, Thomas Secher, Thea T. Johansen, Sebastian T. Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B. Thomsen, Nora E. Zois
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Daniel Vest Christophersen, Peter Moller, Morten Baekgaard Thomsen, Jens Lykkesfeldt, Steffen Loft, Hakan Wallin, Ulla Vogel, Nicklas Raun Jacobsen
Summary: Exposure to SAA through the lungs accelerates atherosclerotic plaque progression, leading to acute phase response, inflammation, and oxidative stress, while also impacting lipid metabolism.
Article
Biochemistry & Molecular Biology
Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W. Mills, Kirstine Calloe, Ulrike Leurs, Johan Z. Ye, Christian Stolte, Morten B. Thomsen, Bo H. Bentzen, Pia R. Lundegaard, Morten S. Olesen, Lars J. Jensen, Jesper Olsen, Alicia Lundby
Summary: Analyzing protein profiles in human and model organisms' cardiac tissues allows for identification of similarities and differences, providing important insights for translational cardiac research across species.
Article
Physiology
Lisa A. Gottlieb, Karin Larsen, Ganesh Halade, Martin E. Young, Morten B. Thomsen
Summary: Mice with cardiomyocyte-specific disruption of the molecular clock genes have lower heart rate and prolonged ventricular repolarization. The QT interval shows diurnal and circadian rhythms independent of heart rate, with increased arrhythmia vulnerability when the cardiac clock is disrupted.
Article
Physiology
Vibeke S. S. Elbrond, Morten B. B. Thomsen, Jonas L. L. Isaksen, Ester D. D. Lunde, Stefano Vincenti, Tobias Wang, Jorgen Tranum-Jensen, Kirstine Calloe
Summary: The purpose of this study was to investigate and evaluate the relationship between the unique electrical axis pattern in the horse heart and the distribution and histology of the conduction system. The results showed that the direction of the electrical axis in the equine heart is determined by the structure of the intramural Purkinje fiber network, rather than being related to ventricular mass.
Article
Cardiac & Cardiovascular Systems
Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer, David R. Rawnsley, Samir Rana, Jin He, Pieterjan Dierickx, Teayoun Kim, Min Xie, Kirk M. Habegger, Masato Kubo, Lufang Zhou, Morten B. Thomsen, Sumanth D. Prabhu, Stuart J. Frank, Paul S. Brookes, Mitchell A. Lazar, Abhinav Diwan, Martin E. Young
Summary: Genetic disruption of the cardiomyocyte clock induces chronic transcriptional repressor E4BP4, which leads to age-onset cardiomyopathy. E4BP4 regulates cardiac metabolism and electrophysiology, making it a novel regulator of both cardiac physiology and pathophysiology.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Meeting Abstract
Physiology
Morten B. Thomsen, Lauren M. Hablitz, Ganesh Halade, Karen Gamble, Marten E. Young, Lisa A. Gottlieb
Article
Physiology
Morten B. Thomsen, Morten S. Nielsen, Annemarie Aarup, Line S. Bisgaard, Tanja X. Pedersen
PHYSIOLOGICAL REPORTS
(2018)
