Article
Clinical Neurology
Gauthier Duloquin, Valentin Crespy, Pauline Jakubina, Maurice Giroud, Catherine Vergely, Yannick Bejot
Summary: The study found that minor ischemic stroke with large vessel occlusion is not uncommon, and its characteristics include severe symptom presentation, decreased consciousness, cortical signs, especially aphasia and altered item level of consciousness. Emergency arterial imaging is needed for patients suspected of acute stroke, including those with minor symptoms, due to the absence of obvious predictors of proximal occlusion.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Osama O. Zaidat, Johanna T. Fifi, Ashish Nanda, Benjamin Atchie, Keith Woodward, Arnd Doerfler, Alejandro Tomasello, Wondwossen Tekle, Inder Paul Singh, Charles Matouk, Joerg Thalwitzer, Tomasz Jargiello, Dmitry Skrypnik, Oliver Beuing, Jerome Berge, Jeffrey M. Katz, Alessandra Biondi, David Bonovich, Sunil A. Sheth, Albert J. Yoo, Ameer E. Hassan
Summary: The COMPLETE registry evaluated the safety and efficacy of the Penumbra System in a real-world setting for treating acute ischemic stroke. The study found that using the Penumbra System for mechanical thrombectomy in patients with large vessel occlusion resulted in comparable outcomes to previous randomized clinical trials.
Review
Clinical Neurology
Michelle C. Johansen
Summary: Accurate determination and diagnosis of ischemic stroke are crucial for providing excellent cerebrovascular care. It helps initiate appropriate prevention strategies, educate patients about specific risk factors, and predict patient outcomes. It also provides an opportunity for patients to participate in research studies and targeted treatments. Advances in research, imaging techniques, biomarkers, and genetic sequencing have challenged the traditional classification of stroke, leading to the identification of new entities and limitations in current diagnostic algorithms. This article reviews the steps for accurate classification and discusses emerging research and future directions in stroke diagnostics and classification.
Article
Clinical Neurology
Anna Richardt, Karoliina Aarnio, Aino Korhonen, Kirsi Rantanen, Liisa Verho, Hannele Laivuori, Mika Gissler, Minna Tikkanen, Petra Ijas
Summary: The etiology and risk factors of pregnancy-associated ischemic stroke were analyzed in this study. It was found that the most common etiologies for pregnancy-associated ischemic stroke were cardioembolism and undetermined causes. Patients with pregnancy-associated ischemic stroke had a higher prevalence of traditional and pregnancy-related stroke risk factors compared to the control group, and the risk increased with the number of risk factors.
EUROPEAN STROKE JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Robson Sarmento Teodoro, Gisele Sampaio Silva, Gabriel Pinheiro Modolo, Stella De Angelis Trivellato, Juli Thomaz de Souza, Gustavo Jose Luvizutto, Helio Rubens de Carvalho Nunes, Luis Cuadrado Martin, Rodrigo Bazan, Silmeia Garcia Zanati Bazan
Summary: Transthoracic echocardiography plays a key role in investigating the etiology of ischemic stroke and reducing the proportion of patients with an undetermined TOAST classification. Echocardiography during hospitalization for ischemic stroke can improve prognosis and reduce in-hospital mortality risk, while being classified as undetermined TOAST type increases the chance of mortality during hospitalization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Kosuke Matsuzono, Takafumi Mashiko, Tadashi Ozawa, Kumiko Miura, Masayuki Suzuki, Yuhei Anan, Reiji Koide, Ryota Tanaka, Tomoaki Kameda, Shigeru Fujimoto
Summary: This study comprehensively analyzes the mortality rate of acute ischemic strokes and reveals real-time survival data during hospitalization and 1 year after the onset of a stroke. The study finds that cardioembolic ischemic strokes are the main cause of death.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Sang Moon Yun, Seyoung Shin, Won Hyuk Chang, Deog Young Kim, Jongmin Lee, Min Kyun Sohn, Min-Keun Song, Yong-Il Shin, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Junhee Han, Jeonghoon Ahn, Gyung-Jae Oh, Yun-Hee Kim
Summary: This study examined gender differences in mortality and functional outcomes after a first-ever ischemic stroke in Korean males and females. The results showed that women had a higher 5-year mortality rate than men, and they also had worse outcomes in ambulatory, cognitive, language, and activities of daily living functions. These findings suggest the need for gender-specific stroke care and long-term management strategies.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Julia Aivo, Jori O. Ruuskanen, Aleksi Tornio, Paivi Rautava, Ville Kyto
Summary: This study found that not using statins after ischemic stroke is associated with adverse long-term outcomes, such as increased all-cause mortality and higher risk of cardiovascular events. Measures to improve timely statin use after stroke are needed.
Article
Clinical Neurology
Durgesh Chaudhary, Ayesha Khan, Shima Shahjouei, Mudit Gupta, Clare Lambert, Venkatesh Avula, Clemens M. Schirmer, Neil Holland, Christoph J. Griessenauer, M. Reza Azarpazhooh, Jiang Li, Vida Abedi, Ramin Zand
Summary: The study found that while the all-cause mortality rate has decreased in ischemic stroke patients from rural areas in the United States, the stroke recurrence rate has significantly increased. Factors independently associated with mortality include older age, atrial fibrillation or flutter, heart failure, and prior ischemic stroke, while diabetes, chronic kidney disease, and age less than 65 years were predictors of ischemic stroke recurrence.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Anna K. Bonkhoff, Nicole Rubsamen, Christian Grefkes, Natalia S. Rost, Klaus Berger, Andre Karch
Summary: This study aims to build and validate prediction models for severe complications after acute ischemic stroke, and found that the performance of these models is superior to previously proposed approaches.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Jenna Broman, Karoliina Aarnio, Anna But, Ivan Marinkovic, Jorge Rodriguez-Pardo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
Summary: The study found that one-fourth of young adults initiated post-stroke antidepressant treatment within 1 year of ischemic stroke. Patients initiating antidepressant treatment had specific clinical characteristics associated with their condition, highlighting the importance of assessing the risk of post-stroke depression during follow-up.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Christian Foerch, Martin A. Schaller-Paule, Helmuth Steinmetz, Bjoern Misselwitz, Ferdinand O. Bohmann
Summary: This study analyzed data from a state-wide stroke registry in Germany to determine if stroke-related disability in the population decreased over time. The results showed a decrease in severe disability and a lower stroke severity score at admission, indicating a positive impact of prevention strategies and acute therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Hyun-Young Choi, Yongil Cho, Wonhee Kim, Yang-Ki Minn, Gu-Hyun Kang, Yong-Soo Jang, Yoonje Lee, Jae-Guk Kim, Jihoon Kim, Youngsuk Cho, Hyungoo Shin, Shinje Moon, Chiwon Ahn, Juncheol Lee, Dong-Geum Shin, Jae-Keun Park
Summary: This study investigated the impact of intracerebral hemorrhage (ICH) on the cumulative mortality of patients with hyperacute ischemic stroke. The results showed that the mortality rate was significantly higher in patients with ICH compared to those without ICH among patients who received intravenous thrombolysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Myung-Sun Song, Yeon joo Choi, Hyunjin Kim, Myung Ji Nam, Chung-woo Lee, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Do-Hoon Kim, Joo-Hyun Park
Summary: The study of very elderly hypertensive patients showed that excessively low blood pressure levels were not always beneficial, and it is important to avoid too low diastolic and systolic blood pressure. Maintaining appropriate blood pressure levels within a certain range is crucial for preventing stroke, myocardial infarction, and all-cause mortality.
Article
Rheumatology
Jae-Bum Jun, Hyun Jung Kim, Sayada Zartasha Kazmi, Taeuk Kang, Kyoung-Beom Kim, Min Ji Kang, Hyeong Sik Ahn
Summary: The incidence of Behcet's disease decreased significantly in the Republic of Korea from 2004 to 2017, especially among women and middle-aged individuals. However, the three-year survival rate of BD patients in the 2011-2017 period was slightly lower compared to the earlier periods.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Chemistry, Organic
Shazia Parveen, Mohamad Hagar, Rua B. Alnoman, Hoda A. Ahmed, El Sayed H. El Ashry, Mohamed A. Zakaria
Summary: A quinazoline derivative was synthesized to potentially act as a VEGFR-2 and Aurora kinase inhibitor. The most stable conformer, syn conformer 3, showed potential to be a dual inhibitor.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Immunology
Jonas Herzberg, Tanja Vollmer, Bastian Fischer, Heiko Becher, Ann-Kristin Becker, Human Honarpisheh, Salman Yousuf Guraya, Tim Strate, Cornelius Knabbe
Summary: In this study, a longitudinal observational study was conducted among employees at a secondary care hospital affected by the COVID-19 pandemic. The study compared the humoral immune response after natural infection or vaccination with different vaccines. The results showed that two doses of BioNTech/Pfizer vaccine resulted in a 100% humoral response rate. The antibody response after one dose of BNT162b2 or Vaxzevria was not significantly different from that after previous PCR-confirmed infection, but significantly lower than that after two doses of BioNTech/Pfizer. Smoking had a negative effect on the antibody response.
Article
Oncology
Nadia Obi, Stefan Werner, Frank Thelen, Heiko Becher, Klaus Pantel
Summary: Bone fractures in breast cancer patients may increase the risk of metastasis, particularly bone metastasis. Fall prevention programs may have potential clinical implications for cancer patients.
Article
Chemistry, Physical
Kanubhai D. Katariya, Rina Soni, Kiran J. Nakum, Shubhangi S. Soman, Mohamed Hagaar
Summary: New coumarin esters with Schiff base linkage and different alkyl chains have been synthesized and studied for their mesomorphic behavior. The compounds were characterized using various analytical techniques and their phase transitions and mesophase behavior were investigated. The results showed that most of the synthesized compounds exhibited enantiotropic nematic phase, and some also displayed enantiotropic smectic C phase. The relationship between the structural parameters and the mesomorphic behavior was explained using DFT theoretical calculations and compared with experimental results.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Abdulghani Ashraf Halabi, Bassma H. Elwakil, Mohamed Hagar, Zakia A. Olama
Summary: In the fight against multidrug resistant bacteria, date fruit extract has shown high antimicrobial activity and can be further enhanced by combining with nanotechnology.
Article
Materials Science, Multidisciplinary
Jehan Y. Al-Humaidi, Mohamed Hagar, Basant A. Bakr, Bassma H. Elwakil, Esraa Abdelhamid Moneer, Mostafa El-Khatib
Summary: This study investigated the antiparasitic effects of ZnO-NPs, GO-NPs, and ZnO-MWCNT in mice infected with Toxoplasma gondii. The results showed a significant reduction in parasite count with ZnO-MWCNT treatment, confirming its superior activity as an antiparasitic agent.
Article
Crystallography
Jehan Y. Al-Humaidi, Shady Nada, Mariam Gerges, Marwa Ehab, Mariusz Jaremko, Abdul-Hamid Emwas, Mohamed Hagar
Summary: A series of liquid crystal compounds with Schiff base and carboxylate ester mesogenic cores, as well as different terminal alkyl chains, have been synthesized and characterized. The phase behavior and properties of these compounds were investigated experimentally and theoretically, and their suitability for applications was evaluated.
Article
Infectious Diseases
Faizah S. Aljohani, Nadjet Rezki, Mohamed R. Aouad, Mohamed Hagar, Basant A. Bakr, Marwa M. Shaaban, Bassma H. Elwakil
Summary: Sulphadiazine-ZnO hybrids exhibit potent activity against bacterial pneumonia by inhibiting metallo-beta-lactamases. In vitro and in vivo experiments demonstrate significant antimicrobial effects of the compound, with potential cytotoxicity observed in a normal cell line.
Article
Chemistry, Medicinal
Fawzia Faleh Albelwi, Hanaa M. Abdu Mansour, Maram M. Elshatanofy, Yeldez El Kilany, Kamal Kandeel, Bassma H. Elwakil, Mohamed Hagar, Mohamed Reda Aouad, El Sayed H. El Ashry, Nadjet Rezki, Maged A. El Sawy
Summary: New 1,2,3-triazole compounds were designed and synthesized for InhA inhibition in tuberculosis treatment. In vitro testing showed promising results, with some compounds exhibiting higher activity than Rifampicin. Molecular docking study was conducted to understand the binding mechanism.
Review
Public, Environmental & Occupational Health
Anja Holz, Maya Riefflin, Christoph Heesen, Karin Riemann-Lorenz, Nadia Obi, Heiko Becher
Summary: This study provides a systematic review and meta-analysis on the influence of breastfeeding during infancy on the risk of developing MS. The results suggest that breastfeeding may have a small protective effect on MS risk.
Article
Biology
Jehan Y. Al-Humaidi, Marwa M. Shaaban, Nadjet Rezki, Mohamed R. Aouad, Mohamed Zakaria, Mariusz Jaremko, Mohamed Hagar, Bassma H. Elwakil
Summary: The study found that some synthesized compounds have high affinity for SARS-CoV-2 and the Omicron variant, preventing viral entry into host cells and reducing viral replication and infection. Among them, compound 9 showed the highest binding affinity for both viruses in vitro.
Article
Biochemistry & Molecular Biology
Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia N. Antonenkova, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Marinus J. Blok, Natalia Bogdanova, Bernardo Bonanni, Barbara Burwinkel, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Melissa H. Cessna, Stephen J. Chanock, Kamila Czene, Peter Devilee, Thilo Doerk, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anna Gonzalez-Neira, Felix Grassmann, Pascal Guenel, Melanie Gundert, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Patricia A. Harrington, Wei He, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, Agnes Jager, Anna Jakubowska, Elza K. Khusnutdinova, Yon-Dschun Ko, Vessela N. Kristensen, Annika Lindblom, Jolanta Lissowska, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, William G. Newman, Nadia Obi, Mihalis Panayiotidis, Muhammad U. Rashid, Valerie Rhenius, Matti A. Rookus, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Reijo Sironen, Melissa C. Southey, Maija Suvanto, Rob A. E. M. Tollenaar, Ian Tomlinson, Therese Truong, Lizet E. van der Kolk, Elke M. van Veen, Barbara Wappenschmidt, Xiaohong R. Yang, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Michael Lush, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Muriel A. Adank, Marjanka K. Schmidt, Irene L. Andrulis, Jenny Chang-Claude, Heli Nevanlinna, Georgia Chenevix-Trench, D. Gareth Evans, Roger L. Milne, Paolo Radice, Paolo Peterlongo
Summary: Evidence from the BRIDGES study suggests that germline protein truncating variants (PTVs) in FANCM are associated with increased risk of ER-negative and triple-negative breast cancer (TNBC), particularly for those with a family history. This study further investigates the association between FANCM missense variants (MVs) and breast cancer risk using the BRIDGES study, analyzing a total of 689 MVs. The results indicate that FANCM MVs may be low/moderate risk factors for ER-negative and TNBC subtypes of breast cancer.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Chemistry, Physical
Kanu D. Katariya, Kiran J. Nakum, Harnish Soni, Shady Nada, Mohamed Hagar
Summary: New imine-based chalcone-ester liquid crystals with symmetric and unsymmetrical alkoxy chains were synthesized and characterized. The mesomorphic behavior of these compounds was studied, and the impact of different mesogenic units on their properties was discussed. Theoretical calculations were performed to explain their mesomorphic behavior in terms of aromaticity and 7C-7C stacking, and experimental results were correlated with calculated parameters such as polarizability, dipole moment, and aspect ratio. Molecular electrostatic potential and frontier molecular orbitals were also considered to demonstrate the influence of terminal chains and mesogenic cores on the energy gap of the frontier molecular orbitals and the distribution of electrostatic charges.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Ayoub M. Abdelalatif, Bassma H. Elwakil, Mohamed Zakaria Mohamed, Mohamed Hagar, Zakia A. Olama
Summary: The spread of antibiotic-resistant opportunistic microbes is a significant socioeconomic burden. In this study, two endophytic fungal strains isolated from Mangifera Indica roots were identified and tested for their antimicrobial activity. The secondary metabolites produced by these fungi showed the highest activity against Staphylococcus aureus and E. coli. Additionally, the combination of these fungal metabolites with a dicationic pyridinium iodide compound exhibited a synergistic effect against Klebsiella pneumoniae.
Article
Oncology
Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Bruening, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, J. Margriet Collee, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Miriam Dwek, Diana M. Eccles, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M. Gapstur, Jose A. Garcia-Saenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna Gonzalez-Neira, Grethe I. Grenaker Alnaes, Mervi Grip, Pascal Guenel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Kruger, Katerina Kubelka-Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Hakan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkas, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Ruediger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schottker, Mark E. Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Montserrat Garcia-Closas, Nilanjan Chatterjee
Summary: This study identifies breast cancer susceptibility variants that are associated with tumor features and intrinsic molecular subtypes, providing insights for subtype-specific risk prediction.
BREAST CANCER RESEARCH
(2022)
