Article
Nanoscience & Nanotechnology
Leela Goel, Huaiyu Wu, Bohua Zhang, Jinwook Kim, Paul A. Dayton, Zhen Xu, Xiaoning Jiang
Summary: The study demonstrates that using nanodroplets combined with tPA-mediated sonothrombolysis can significantly enhance the dissolution of retracted blood clots, compared to traditional MB and tPA-mediated techniques.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Biophysics
Chayut Teeraratkul, Debanjan Mukherjee
Summary: This study develops a microstructure aware model for species transport within and around a macroscale thrombus, using a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions. The research demonstrates the formation of coherent flow structures around the thrombus and characterizes species transport from bulk flow to the thrombus boundary.
JOURNAL OF BIOMECHANICS
(2021)
Article
Pharmacology & Pharmacy
Maria Luz Alonso-Alonso, Maria Perez-Mato, Ana Sampedro-Viana, Clara Correa-Paz, Paulo Avila-Gomez, Tomas Sobrino, Francisco Campos, Jose Castillo, Ramon Iglesias-Rey, Pablo Hervella
Summary: In this study, a new dual MRI nanoparticle was developed to predict the efficacy of recanalization treatment and improve the triage of ischemic stroke patients by targeting the fibrin content of blood clots.
Article
Clinical Neurology
Francisco Hernandez-Fernandez, Maria E. Ramos-Araque, Rosa Barbella-Aponte, Juan David Molina-Nuevo, Jorge Garcia-Garcia, Oscar Ayo-Martin, Maria Jose Pedrosa-Jimenez, Lorena Lopez-Martinez, Gemma Serrano-Heras, Enrique Julia-Molla, Tomas Segura
Summary: The histological composition of the clot can affect the efficacy of endovascular treatment for acute ischemic stroke (AIS). Fibrin-predominant clot patients were more likely to achieve complete recanalization when stent retrievers were used, but also had a higher mortality rate. CRP levels and the presence of HMCA were closely associated with clot composition.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Sean Fitzgerald, Rosanna Rossi, Oana Madalina Mereuta, Sara Molina, Adaobi Okolo, Andrew Douglas, Duaa Jabrah, Abhay Pandit, Ray McCarthy, Michael Gilvarry, Erik Ceder, Niclas Dehlfors, Dennis Dunker, Annika Nordanstig, Petra Redfors, Katarina Jood, Georgios Magoufis, Klearchos Psychogios, Georgios Tsivgoulis, Jack Alderson, Alan O'Hare, Sarah Power, Paul Brennan, Andras Nagy, Agnes Vadasz, Waleed Brinjikji, David Kallmes, Istvan Szikora, Turgut Tatlisumak, Alexandros Rentzos, John Thornton, Karen M. Doyle
Summary: This study found that the size of Extracted Clot Area (ECA) in large-artery atherosclerosis (LAA) clots was double that of other etiologies, leading to a lower rate of successful recanalization in LAA stroke subtype. Additionally, the administration of recombinant tissue plasminogen activator (rtPA) was associated with reduced ECA in LAA and cardioembolic (CE) clots.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Physics, Applied
Howuk Kim, Bohua Zhang, Huaiyu Wu, Junjie Yao, Chengzhi Shi, Xiaoning Jiang
Summary: Endovascular sonothrombolysis has received attention for its advantages of targeted thrombus dissolution and reduced side effects. However, the small size of endovascular transducers limits their clinical efficiency. In this study, vortex ultrasound was used to generate shear stress and enhance clot lysis. In vitro tests showed that the vortex ultrasound achieved higher lysis rates compared to non-vortex ultrasound, suggesting its potential as a clinical option for thrombolysis.
APPLIED PHYSICS LETTERS
(2023)
Article
Medicine, General & Internal
Mudassir Farooqui, Osama O. Zaidat, Ameer E. Hassan, Darko Quispe-Orozco, Nils Petersen, Afshin A. Divani, Marc Ribo, Michael Abraham, Johanna Fifi, Waldo R. Guerrero, Amer M. Malik, James E. Siegler, Thanh N. Nguyen, Sunil Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Milagros Galecio-Castillo, Wondewossen G. Tekle, Victor M. Ringheanu, Marion Oliver, Giana Dawod, Jessica Kobsa, Ayush Prasad, Asad Ikram, Eugene Lin, Kristine Below, Cynthia B. Zevallos, Marta Olive Gadea, Abid Qureshi, Andres Dajles, Stavros Matsoukas, Ameena Rana, Mohamad Abdalkader, Sergio Salazar-Marioni, Jazba Soomro, Weston Gordon, Juan Vivanco-Suarez, Charoskhon Turabova, Maxim Mokin, Dileep R. Yavagal, Mouhammad A. Jumaa, Santiago Ortega-Gutierrez
Summary: This study aimed to evaluate the management of patients with intracranial large vessel occlusion combined with cervical artery stenosis or occlusion. The study found that carotid artery stenting during mechanical thrombectomy can improve functional outcomes and successful reperfusion without increasing the risk of symptomatic intracranial hemorrhage and mortality.
Article
Neuroimaging
Oana Madalina Mereuta, Sean Fitzgerald, Trace A. Christensen, Adam L. Jaspersen, Daying Dai, Mehdi Abbasi, Tejaswini Puttappa, Ram Kadirvel, David F. Kallmes, Karen M. Doyle, Waleed Brinjikji
Summary: This study analyzed the composition and microstructure of AIS clots in 10 patients using histology and SBFSEM. Fibrin and red blood cells were the main components, with varying organization in different regions possibly influenced by thrombolytic treatment. The findings provide valuable insights for thrombolytic treatment and medical device design.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Zsuzsa Bagoly, Barbara Barath, Rita Orban-Kalmandi, Istvan Szegedi, Reka Bogati, Ferenc Sarkady, Laszlo Csiba, Eva Katona
Summary: The study found that increased levels of FXIII lead to higher incorporation of alpha 2-PI into fibrin clots, and in ischemic stroke patients, the extent of alpha 2-PI incorporation is associated with the outcomes of thrombolytic therapy, particularly with thrombolysis-associated intracranial hemorrhage.
Article
Hematology
David Cabrera, Maneea Eizadi Sharifabad, Jacob A. Ranjbar, Neil D. Telling, Alan G. S. Harper
Summary: This study developed clot-targeting magnetic nanoparticles and used magnetic hyperthermia to enhance tPA-mediated thrombolysis of contracted human blood clots. The clot-targeted magnetic hyperthermia increased the permeability of the clots to tPA, facilitating their breakdown. Importantly, endothelial cell viability was unaffected by the clot-targeted magnetic hyperthermia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Hannes Nordmeyer, Nebiyat Filate Belachew, Timo Huan Phung, Jan Gralla, Sara Molina Gil, Andrew Douglas, Stephanie Neuhaus, Patrick Haage, Karen Doyle, Pasquale Mordasini
Summary: This retrospective study evaluated the clinical use of the NIMBUS Geometric Clot Extractor for mechanical thrombectomy. The results demonstrated that NIMBUS was effective in removing tough clots rich in fibrin and platelets in real-world situations.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pavel Bobrovsky, Valentin Manuvera, Izolda Baskova, Svetlana Nemirova, Alexandr Medvedev, Vassili Lazarev
Summary: In this study, the feasibility and effectiveness of using destabilase in relation to blood clots formed during real pathological processes were evaluated. The researchers found that destabilase can be considered as a potential drug for the treatment of aged clots, which are difficult to treat with known thrombolytics. Destabilase is able to destroy isopeptide bonds in both aged and fresh blood clots, and its effect coincides with the morphological characteristics of the clots.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Johanna Haertl, Maria Berndt, Holger Poppert, Friederike Liesche-Starnecker, Katja Steiger, Silke Wunderlich, Tobias Boeckh-Behrens, Benno Ikenberg
Summary: Although it is difficult to prove the pathophysiological impact of a patent foramen ovale (PFO) in individual patient care, it is considered to be of high relevance for secondary prophylaxis in selected patients with cryptogenic ischemic stroke. This study aimed to enhance the understanding of PFO attributable ischemic strokes by quantifying the histological clot composition. The results showed that the clot composition varied depending on the presence of a PFO, supporting the concept that a PFO may be of pathophysiological relevance in cryptogenic ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
John W. Weisel
Summary: In this study, Han et al investigated the role of leukocyte inflammation in trauma-induced coagulopathy using in vitro and in vivo models. They found that the inflammation caused oxidation and digestion of fibrinogen, leading to the coagulopathy, and they also demonstrated that inhibiting the inflammatory processes could prevent the modifications of fibrinogen and the development of trauma-induced coagulopathy.
Article
Engineering, Mechanical
Dongjing He, Dongjune A. Kim, David N. Ku, Yuhang Hu
Summary: This study quantitatively characterizes the mechanical properties of blood clots using rheology and indentation measurements. The research finds that blood clots exhibit both viscoelastic and poroelastic behavior. The viscoelasticity is determined through shear rheology measurements, while the poroelastic properties are obtained through indentation tests. The study also discusses the contribution of solvent migration and viscoelastic effects to the time-dependent responses of blood clots.
EXTREME MECHANICS LETTERS
(2022)