Journal
CEREBROVASCULAR DISEASES
Volume 28, Issue 3, Pages 306-313Publisher
KARGER
DOI: 10.1159/000229017
Keywords
Magnetic resonance imaging; Positron emission tomography; Cerebral ischemia
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Funding
- MRC [G0001237, G0600986, G9439390] Funding Source: UKRI
- Medical Research Council [G0600986, G0001237, G9439390] Funding Source: Medline
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
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Background: Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF. Methods: We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7-21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF. Results: All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects. Conclusion: We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke. Copyright (C) 2009 S. Karger AG, Basel
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