Review
Clinical Neurology
Konark Malhotra, Christina Zompola, Aikaterini Theodorou, Aristeidis H. Katsanos, Ashkan Shoamanesh, Himanshu Gupta, Simon Beshara, Nitin Goyal, Jason Chang, Ashis H. Tayal, Efstathios Boviatsis, Konstantinos Voumvourakis, Charlotte Cordonnier, David J. Werring, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: Among patients with spontaneous intracerebral hemorrhage, approximately 1 in 4 cases have undetermined etiology, leading to a relatively high short-term mortality rate. Cerebral amyloid angiopathy accounts for the largest hemorrhage volume, while hypertensive arteriopathy and undetermined ICH have smaller volumes.
Article
Clinical Neurology
Aayushi Garg, Santiago Ortega-Gutierrez, Mudassir Farooqui, Nandakumar Nagaraja
Summary: This study found that patients with intracerebral hemorrhage (ICH) and concomitant cerebral amyloid angiopathy (CAA) are three times more likely to have readmissions for recurrent ICH compared to patients without CAA.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Mengke Zhang, Ruiwen Che, Wenbo Zhao, Hailiang Sun, Changhong Ren, Jin Ma, Wenbo Hu, Milan Jia, Chuanjie Wu, Xin Liu, Xunming Ji
Summary: This study aimed to explore the relationship between computed tomography (CT)-based cerebral small vessel disease (SVD) markers and the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). The results showed that the SVD markers based on CT could predict the short-term outcome more effectively in patients with CAA-ICH. Further studies are needed to validate these findings and identify modifiable factors for preventing CAA-ICH development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Russell P. Sawyer, Stacie L. Demel, Mary E. Comeau, Miranda Marion, Jonathan Rosand, Carl D. Langefeld, Daniel Woo
Summary: Apolipoprotein E alleles are associated with both Alzheimer's disease and intracerebral hemorrhage; intracerebral hemorrhage has a high risk of subsequent dementia; variations in CR1 and CLU genes are associated with an increased risk of lobar ICH.
Review
Clinical Neurology
Howard Kirshner, Matthew Schrag
Summary: Intracerebral hemorrhage (ICH) accounts for 15% of all strokes in the US, yet almost 50% of fatal strokes. The most common causes are hypertension and cerebral amyloid angiopathy. Treatment focuses on managing edema, reducing blood pressure, and correcting coagulopathy. Current standard of care includes supportive therapies, but there is no definitive curative therapy like mechanical thrombectomy for ischemic stroke. New medical and surgical approaches show promise in improving ICH management.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Clinical Neurology
Yuyi Zhu, Lu Liu, Luyao Zhong, Yajun Cheng, Shihong Zhang, Bo Wu, Deren Wang, Mangmang Xu
Summary: The study aims to investigate the association between burden of cerebral small vessel disease (CSVD) caused by hypertensive angiopathy (HA) and cerebral amyloid angiopathy (CAA) on MRI in patients with primary intracerebral hemorrhage (ICH). The results showed a significant association between HA-CSVD and CAA-CSVD, which needs to be confirmed in future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Review
Clinical Neurology
Mangmang Xu, Yuyi Zhu, Xindi Song, Xuelian Zhong, Xinxin Yu, Deren Wang, Yajun Cheng, Wendan Tao, Bo Wu, Ming Liu
Summary: In this systematic review and meta-analysis, we investigated the relationship between cerebral amyloid angiopathy (CAA) and arteriolosclerosis in intracerebral hemorrhage (ICH) patients. We also compared the MRI and pathological changes of markers of cerebral small vessel disease (CSVD). The results indicated that severe CAA was potentially associated with arteriolosclerosis. Patients with evidence of CAA had a higher number of microbleeds compared to those without CAA. However, further research is needed to explore the pathological changes of CSVD markers according to the etiology of ICH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Evangelos Pavlos Myserlis, Christopher D. Anderson, Marios K. Georgakis
Summary: Recent evidence suggests that higher CRP levels are associated with lower risk of Alzheimer disease, and this study explores whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH) caused by cerebral amyloid angiopathy. The results show that higher genetically proxied CRP levels are associated with lower odds of lobar ICH, supporting the hypothesis that high CRP levels may have a protective role in amyloid-related pathology.
Article
Medicine, General & Internal
Carmen Barbato, Piergiuseppe Liuzzi, Anna Maria Romoli, Francesca Draghi, Daniela Maccanti, Andrea Mannini, Claudio Macchi, Francesca Cecchi, Bahia Hakiki
Summary: This study found that sporadic CAA associated with cerebral hemorrhage is independently associated with poorer rehabilitation outcomes, regardless of age. This suggests the importance of improving knowledge about CAA to better predict rehabilitation outcomes.
Article
Clinical Neurology
Wilmar M. T. Jolink, Susanne J. van Veluw, Jaco J. M. Zwanenburg, Annemieke J. M. Rozemuller, Wim van Hecke, Matthew P. Frosch, Brian J. Bacskai, Gabriel J. E. Rinkel, Steven M. Greenberg, Catharina J. M. Klijn
Summary: In this study, the histopathological features of cerebral microinfarcts (CMIs) and cerebral microbleeds (CMBs) in patients with spontaneous intracerebral hemorrhage (ICH) caused by different vasculopathies were investigated. The results suggest shared pathophysiological mechanisms in lobar and non-lobar ICH caused by different vasculopathies.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Article
Clinical Neurology
Giuseppe Scopelliti, Barbara Casolla, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Didier Leys, Hilde Henon, Charlotte Cordonnier, Marco Pasi
Summary: Anxiety is common among survivors of spontaneous intracerebral hemorrhage (ICH), often occurring together with depressive symptoms even years after the initial event. Lobar ICH location is significantly associated with anxiety 1-2 years after ICH.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Medicine, General & Internal
Paula Marazuela, Anna Bonaterra-Pastra, Julia Faura, Anna Penalba, Jesus Pizarro, Olalla Pancorbo, David Rodriguez-Luna, Carla Vert, Alex Rovira, Francesc Pujadas, M. Mar Freijo, Silvia Tur, Maite Martinez-Zabaleta, Pere Cardona Portela, Rocio Vera, Lucia Lebrato-Hernandez, Juan F. Arenillas, Soledad Perez-Sanchez, Joan Montaner, Pilar Delgado, Mar Hernandez-Guillamon
Summary: Studies have shown that circulating levels of AQP4 are lower in patients with lobar intracerebral hemorrhage, and may be associated with hemorrhagic features and long-term functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rehabilitation
Lynley Bradnam, Celia Chen, Lynton Graetz, Tobias Loetscher
DISABILITY AND REHABILITATION
(2020)
Article
Multidisciplinary Sciences
Ebony Liu, Georgia Kaidonis, Mark C. Gillies, Sotoodeh Abhary, Rohan W. Essex, John H. Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Jolly Gilhotra, Nikolai Petrovsky, Alex W. Hewitt, Alicia Jenkins, Ecosse L. Lamoureux, Jonathan M. Gleadle, Kathryn P. Burdon, Jamie E. Craig
SCIENTIFIC REPORTS
(2019)
Review
Ophthalmology
Michael Kvopka, Stewart R. Lake, Justine R. Smith
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Clinical Neurology
Wajih Bukhari, Laura Clarke, Cullen O'Gorman, Elham Khalilidehkordi, Simon Arnett, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, Sudarshini Ramanathan, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Celia Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Keith Dear, Marzena J. Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor J. Kilpatrick, John King, Chris Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonnell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Stephen W. Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. Kermode, Mark P. Marriott, John Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Robert J. Wilson, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
JOURNAL OF NEUROLOGY
(2020)
Article
Ophthalmology
Pavani Kurra, Laima Brazionis, Jesse Gale, Katie Chen, Stewart Lake, Kristy P. Robledo, Tim Henderson
OPHTHALMIC EPIDEMIOLOGY
(2020)
Article
Multidisciplinary Sciences
Tobias Strunz, Susette Lauwen, Christina Kiel, Anneke den Hollander, Bernhard H. F. Weber
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Brian Mac Grory, Alex Nackenoff, Sven Poli, Martin S. Spitzer, Max Nedelmann, Benoit Guillon, Cecile Preterre, Celia S. Chen, Andrew W. Lee, Shadi Yaghi, Christoph Stretz, Idrees Azher, John Paddock, Tatiana Bakaeva, David M. Greer, Julie G. Shulman, Robert G. Kowalski, Patrick Lavin, Eva Mistry, Kiersten Espaillat, Karen Furie, Howard Kirshner, Matthew Schrag
Article
Clinical Neurology
Elham Khalilidehkordi, Laura Clarke, Simon Arnett, Wajih Bukhari, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Matthew Brown, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Celia Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Chris Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. Kermode, Mark P. Marriott, John Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
FRONTIERS IN NEUROLOGY
(2020)
Article
Ophthalmology
Stewart R. Lake, Murk J. Bottema, Keryn A. Williams, Tyra Lange, Karen J. Reynolds
Summary: This study used irregularities in retinal shape from optical coherence tomography (OCT) images as a biomarker for retinal detachment and developed a classifier to identify retinal detachment eyes. The results showed that the classifier had a moderate accuracy in identifying retinal detachment eyes.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Stewart R. Lake, Murk J. Bottema, Tyra Lange, Keryn A. Williams, Karen J. Reynolds
Summary: Irregularities in retinal shape were found to be associated with axial length, and the irregularity of the mid-peripheral retina can identify eyes that have experienced a retinal detachment. Peripheral retinal irregularity is a better biomarker for retinal detachment than axial length.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Queena Qin, Celia Chen, Sudha Cugati
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2020)
Review
Ophthalmology
Celia S. Chen, Daniel Varma, Andrew Lee
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2020)
Meeting Abstract
Ophthalmology
Stewart Lake, Murk Bottema, Keryn Williams, Karen Reynolds
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
Ebony Liu, Georgia Kaidonis, Bennet J. McComish, Mark C. Gillies, Sotoodeh Abhary, Rohan W. Essex, John H. Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Nikolai Petrovsky, Alex W. Hewitt, Alicia Jenkins, Ecosse L. Lamoureux, Jonathan M. Gleadle, Jamie E. Craig, Kathryn P. Burdon
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
Andrea R. Waksmunski, Michelle Grunin, Tyler G. Kinzy, Robert P. Igo, Jonathan L. Haines, Jessica N. Cooke Bailey, Lars G. Fritsche, Wilmar Igl, Felix Grassmann, Sebanti Sengupta, Jennifer L. Bragg-Gresham, Kathryn P. Burdon, Scott J. Hebbring, Cindy Wen, Mathias Gorski, Ivana K. Kim, David Cho, Donald Zack, Eric Souied, Hendrik P. N. Scholl, Elisa Bala, Kristine E. Lee, David J. Hunter, Rebecca J. Sardell, Paul Mitchell, Joanna E. Merriam, Valentina Cipriani, Joshua D. Hoffman, Tina Schick, Yara T. E. Lechanteur, Robyn H. Guymer, Matthew P. Johnson, Yingda Jiang, Chloe M. Stanton, Gabrielle H. S. Buitendijk, Xiaowei Zhan, Alan M. Kwong, Alexis Boleda, Matthew Brooks, Linn Gieser, Rinki Ratnapriya, Kari E. Branham, Johanna R. Foerster, John R. Heckenlively, Mohammad Othman, Brendan J. Vote, Helena Hai Liang, Emmanuelle Souzeau, Ian L. McAllister, Timothy Isaacs, Janette Hall, Stewart Lake, David A. Mackey, Ian J. Constable, Jamie E. Craig, Terrie E. Kitchner, Zhenglin Yang, Zhiguang Su, Hongrong Luo, Daniel Chen, Hong Ouyang, Ken Flagg, Danni Lin, Guanping Mao, Henry Ferreyra, Klaus Stark, Claudia N. von Strachwitz, Armin Wolf, Caroline Brandl, Guenther Rudolph, Matthias Olden, Margaux A. Morrison, Denise J. Morgan, Matthew Schu, Jeeyun Ahn, Giuliana Silvestri, Evangelia E. Tsironi, Kyu Hyung Park, Lindsay A. Farrer, Anton Orlin, Alexander Brucker, Mingyao Li, Christine A. Curcio, Saddek Mohand-Said, Jose-Alain Sahel, Isabelle Audo, Mustapha Benchaboune, Angela J. Cree, Christina A. Rennie, Srinivas Goverdhan, Shira Hagbi-Levi, Peter Campochiaro, Nicholas Katsanis, Frank G. Holz, Frederic Blond, Helene Blanche, Jean-Francois Deleuze, Barbara Truitt, Neal S. Peachey, Stacy M. Meuer, Chelsea E. Myers, Emily L. Moore, Ronald Klein, Michael A. Hauser, Eric A. Postel, Monique D. Courtenay, Stephen G. Schwartz, Jaclyn L. Kovach, William K. Scott, Gerald Liew, Ava G. Tan, Bamini Gopinath, John C. Merriam, R. Theodore Smith, Jane C. Khan, Humma Shahid, Anthony T. Moore, J. Allie McGrath, Renee Laux, Milam A. Brantley, Anita Agarwal, Lebriz Ersoy, Albert Caramoy, Thomas Langmann, Nicole T. M. Saksens, Eiko K. de Jong, Carel B. Hoyng, Melinda S. Cain, Andrea J. Richardson, Tammy M. Martin, John Blangero, Daniel E. Weeks, Bal Dhillon, Cornelia M. van Duijn, Kimberly F. Doheny, Jane Romm, Caroline C. W. Klaver, Caroline Hayward, Michael B. Gorin, Michael L. Klein, Paul N. Baird, Anneke den Hollander, Sascha Fauser, John R. W. Yates, Rando Allikmets, Jie Jin Wang, Debra A. Schaumberg, Barbara E. K. Klein, Stephanie A. Hagstrom, Itay Chowers, Andrew J. Lotery, Thierry Leveillard, Kang Zhang, Murray H. Brilliant, Alex W. Hewitt, Anand Swaroop, Emily Y. Chew, Margaret A. Pericak-Vance, Margaret DeAngelis, Dwight Stambolian, Sudha K. Iyengar, Bernhard H. F. Weber, Goncalo R. Abecasis, Iris M. Heid
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
