Article
Clinical Neurology
Huihui Liu, Mengxing Wang, Xianglong Xiang, Yuesong Pan, Jiejie Li, Xia Meng, Hao Li, Zixiao Li, Jing Jing, Yongjun Wang
Summary: This study found that persistent high residual inflammatory risk (RIR) increased the risks of stroke recurrence, composite vascular events, mortality, and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jed W. Smith, Raphae S. Barlas, Mamas A. Mamas, S. Matthijs Boekholdt, Ziad Mallat, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw, Phyo K. Myint
Summary: A nested case-control study found that sPLA2 activity, but not concentration, is associated with an increased risk of future ischaemic stroke. This finding may have implications for risk group stratification and the development of novel therapeutic agents.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Hui-qin Yang, Wen-Jun Yin, Kun Liu, Man-Cang Liu, Xiao-cong Zuo
Summary: This study suggests that edaravone does not increase the nephrotoxicity of aspirin in patients with ischemic stroke, and even has a protective effect on mild renal deterioration. However, caution should be exercised when patients are in poor pathophysiological conditions and at high risk of bleeding.
Article
Biochemistry & Molecular Biology
Laia Llucia-Carol, Elena Muino, Natalia Cullell, Jara Carcel-Marquez, Miquel Lledos, Cristina Gallego-Fabrega, Jesus Martin-Campos, Joan Marti-Fabregas, Ana Aguilera-Simon, Anna M. Planas, Marta L. Dediego, Alicia de Felipe Mimbrera, Jaime Masjuan, Sebastian Garcia-Madrona, Tomas Segura, Esther Gonzalez-Villar, Gemma Serrano-Heras, Ana Dominguez Mayoral, Paloma Menendez-Valladares, Joan Montaner, Isabelle Migeotte, Souad Rahmouni, Gilles Darcis, David Bernardo, Silvia Rojo, Eva C. Schulte, Ulrike Protzer, Lisa Fricke, Christof Winter, Mari E. K. Niemi, Mattia Cordioli, Pilar Delgado, Israel Fernandez-Cadenas
Summary: This study aimed to determine if patients with IS-COV are associated with a specific aetiology of IS. The researchers used genetic analysis to identify genome regions that correlated between the IS-COV cohort and different subtypes of IS, finding three genomic regions associated with LAA and CES. They also found four genetic loci related to specific genes. The results suggest that IS-COV cases are genetically similar to LAA and CES subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ziad Hijazi, Alexander P. Benz, Johan Lindback, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Christopher B. Granger, Peter Kastner, Renato D. Lopes, Andre Ziegler, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
Summary: In this study, BMP10 may be a novel specific biomarker of ischaemic stroke in patients with atrial fibrillation, irrespective of oral anticoagulation.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Shinwan Kany, Christoph Al-Taie, Carolina Roselli, James P. Pirruccello, Katrin Borof, Carla Reinbold, Anna Suling, Linda Krause, Bruno Reissmann, Renate B. Schnabel, Tanja Zeller, Antonia Zapf, Karl Wegscheider, Larissa Fabritz, Patrick T. Ellinor, Paulus Kirchhof
Summary: The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial has shown that early rhythm control is effective in reducing cardiovascular events in patients with atrial fibrillation (AF). However, the interaction between genetic predisposition to AF and stroke and early rhythm control therapy is still unknown.
CARDIOVASCULAR RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Yuhan Zang, Zhengbao Zhu, Mengyao Shi, Aili Wang, Xuewei Xie, Tan Xu, Yanbo Peng, Pinni Yang, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Liping Liu, Yonghong Zhang, Jiang He
Summary: This study investigated the association between annual household income and prognosis of ischaemic stroke. The findings indicated that low annual household income was significantly associated with increased risks of adverse clinical outcomes after ischaemic stroke. Further studies are needed to replicate these findings in other samples.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Medicine, General & Internal
Runhua Zhang, Gaifen Liu, Yuesong Pan, Maigeng Zhou, Yongjun Wang
Summary: This study aimed to assess the association between hospital volume, processes of care, and outcomes after ischaemic stroke. The results showed no significant associations between hospital volume and mortality, recurrent stroke, and combined vascular events, but it may be associated with poor outcome at 1 year.
Article
Medicine, General & Internal
Hong-Qiu Gu, Kai-Xuan Yang, Jin-Xi Lin, Jing Jing, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Xia Meng, Yong Jiang, Hao Li, Yong-Jun Wang, Zi-Xiao Li
Summary: Post-stroke inflammation biomarker hsCRP is associated with increased cerebral infarct size, functional disability, and stroke recurrence risk. However, only less than 20% of the association between hsCRP and functional disability was mediated by stroke recurrence.
Review
Clinical Neurology
Christoph Stretz, Teddy Y. Wu, Duncan Wilson, David J. Seiffge, Eric E. Smith, M. Edip Gurol, Shadi Yaghi
Summary: Although anticoagulation significantly reduces the risk of stroke in patients with atrial fibrillation, a proportion of patients on anticoagulation still experience ischaemic stroke. Understanding the potential mechanisms of stroke despite anticoagulation is crucial in order to tailor individualized treatment strategies for secondary prevention.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Yu-Yuan Xu, Wei-Qi Chen, Meng-Xing Wang, Yue-Song Pan, Zi-Xiao Li, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Hao Li, Yong-Jun Wang, Xia Meng
Summary: This study aimed to assess the management of LDL-C and goal achievement in patients with ischemic stroke or TIA, as well as the association between baseline LDL-C level, LLT, and stroke recurrence. A post hoc analysis of the CNSR-III showed a mild increase in LDL-C goal achievement rate among stroke and TIA patients in mainland China. Lower baseline LDL-C level was significantly associated with a decreased short- and long-term risk of ischemic stroke.
Article
Medicine, General & Internal
Jenna Broman, Karoliina Aarnio, Anna But, Ivan Marinkovic, Jorge Rodriguez-Pardo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
Summary: This study examined the association between the initiation of antidepressants within the first year after ischaemic stroke in young adults and long-term fatal and non-fatal cardiovascular events, as well as all-cause mortality. The results showed that initiating antidepressants within the first year after stroke was associated with a heightened hazard of recurrent ischaemic or haemorrhagic stroke in the long term.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Paul Reidler, Alex Brehm, Peter B. Sporns, Vanessa Granja Burbano, Lena Stueckelschweiger, Gabriel Broocks, Thomas Liebig, Marios-Nikos Psychogios, Jens Ricke, Konstantinos Dimitriadis, Martin Dichgans, Wolfgang G. Kunz, Steffen Tiedt
Summary: The study found that human stroke progression varies across the 24-hour cycle, with patients who have nocturnal stroke onset showing larger infarct core volumes and faster core growth. These findings have implications for the design and interpretation of neuroprotection trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Hematology
Eric Jay Earley, Shannon Kelly, Fang Fang, Cecilia Salete Alencar, Daniela de Oliveira Werneck Rodrigues, Dahra Teles Soares Cruz, Jonathan M. Flanagan, Russell E. Ware, Xu Zhang, Victor Gordeuk, Mark Gladwin, Yingze Zhang, Mehdi Nouraie, Sergei Nekhai, Ester Sabino, Brian Custer, Carla Dinardo, Grier P. Page
Summary: This study performed a genome-wide association study on 1333 individuals with sickle cell disease (SCD) from Brazil and identified variants associated with early-onset ischaemic stroke. The study also found a shared genetic architecture between SCD individuals and non-SCD individuals younger than 65 years.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Clinical Neurology
Carolin Beuker, Jeanette Koeppe, Jannik Feld, Christian Lennart Meyer, Patrik Droege, Thomas Ruhnke, Christian Guenster, Heinz Wiendl, Holger Reinecke, Jens Minnerup
Summary: A retrospective cohort study found that age is strongly associated with long-term outcomes after mechanical thrombectomy for stroke patients. Patients aged 80 and above had higher mortality, disability, and worse living conditions compared to younger patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Max J. van Hout, Ilona A. Dekkers, Ling Lin, Jos J. Westenberg, Martin J. Schalij, J. Wouter Jukema, Ralph L. Widya, Sebastiaan C. Boone, Renee de Mutsert, Frits R. Rosendaal, Arthur J. Scholte, Hildo J. Lamb
Summary: This study calculated estimated-PWV (ePWV) based on clinical and anthropometric measures, determining PWV <6.7 m/s as the optimal discriminative value. Linear ridge regression and Deep Neural Network (DNN) models showed similar performance, with the expanded ridge regression model performing best in external validation.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Psychology, Clinical
Tahani Alshehri, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Richard Dinga, Brenda W. J. H. Penninx, Frits R. Rosendaal, Saskia le Cessie, Yuri Milaneschi
Summary: Combining data on metabolomics and depressive symptoms, researchers identified a replicable depression dimension associated with adverse metabolic alterations, supporting the hypothesis of immune-metabolic depression. Patients with this type of depression may have a higher cardiometabolic risk.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Article
Endocrinology & Metabolism
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renee de Mutsert
Summary: This study found that the number of breaks in sedentary time was not associated with lower liver fat content or reduced insulin resistance. However, engaging in moderate-to-vigorous physical activity in the afternoon or evening was associated with a reduction of up to 25% in insulin resistance. Further research should investigate whether the timing of physical activity also plays an important role in the occurrence of type 2 diabetes.
Article
Critical Care Medicine
Ishita P. Miah, Anastassia Blanter, Yeliz Tank, Erik W. van Zwet, Frits R. Rosendaal, Wilco C. Peul, Ruben Dammers, Dana C. Holl, Hester F. Lingsma, Heleen M. den Hertog, Joukje van der Naalt, Korne Jellema, Niels A. Van der Gaag
Summary: Surgical intervention is the main treatment strategy for chronic subdural hematoma. Recent trials have shown that dexamethasone therapy is ineffective in symptomatic patients. This study aimed to identify which hematoma subtype is favorable for dexamethasone therapy.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medical Ethics
B. Siegerink, L. A. Pet, F. R. Rosendaal, M. Y. H. G. Erkens
Summary: In this paper, we discuss the arguments for adopting a jurisprudence platform for scientific misconduct. We argue that this platform will enhance the principle of legal certainty, improve procedures, and indirectly promote scientific integrity. Using the Netherlands as an example, we also describe the prerequisites, content, and international significance of such a platform.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2023)
Article
Immunology
Tahani Alshehri, Dennis O. Mook-Kanamori, Renee de Mutsert, Brenda W. J. H. Penninx, Frits R. Rosendaal, Saskia le Cessie, Yuri Milaneschi
Summary: Genomics research shows that adiposity is linked to atypical energy-related symptoms (AES) of depression. The link between obesity and AES depends on the presence of metabolic dysregulations. The results highlight the connection between adiposity and metabolic dysregulations.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Tariq O. Faquih, N. Ahmad Aziz, Sarah L. Gardiner, Ruifang Li-Gao, Renee de Mutsert, Yuri Milaneschi, Stella Trompet, J. Wouter Jukema, Frits R. Rosendaal, Astrid van Hylckama Vlieg, Ko Willems van Dijk, Dennis O. Mook-Kanamori
Summary: Based on the data from three European cohorts, this study found that non-pathogenic CAG repeat sizes below 36 in the HTT gene are associated with abnormal metabolite levels, which may be mediated through lower BMI.
HUMAN MOLECULAR GENETICS
(2023)
Editorial Material
Health Care Sciences & Services
Rafael Dal-Re, Raphael Porcher, Frits R. Rosendaal, Brigitte Schwarzer-Daum
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Rheumatology
Coen van der Meulen, Lotte A. van de Stadt, Frits R. Rosendaal, Jos Runhaar, Margreet Kloppenburg
Summary: This study investigated pain, pain trajectories, and their determinants in hand osteoarthritis (OA) patients. It was found that pain levels were associated with patient and disease characteristics, as well as psychosocial factors. Three pain trajectories were identified in hand OA patients, with different baseline pain levels and stable pain over time.
Article
Anesthesiology
Heather E. van Brug, Rob G. H. Nelissen, Frits R. Rosendaal, Liza N. van Steenbergen, Eveline L. A. van Dorp, Marcel L. Bouvy, Albert Dahan, Maaike G. J. Gademan
Summary: This study in the Netherlands examined the first prescribed opioids and the prescribers after knee and hip arthroplasty between 2013 and 2018. It found that the dose of the first prescribed opioid was associated with the total dispensed dose and long-term opioid use in the first year post-surgery. Orthopaedic surgeons primarily prescribed the first prescription, while general practitioners were responsible for consecutive prescriptions.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Letter
Anesthesiology
Lodewijk A. Pet, Willian J. van Dijk, Bob Siegerink, Frits R. Rosendaal
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Christen, Renee de Mutsert, Roelof AJ. Smit, Ko Willems van Dijk, Hildo J. Lamb, Frits R. Rosendaal, J. Wouter Jukema, Stella Trompet
Summary: This study investigated the association between leptin and heart function and subclinical cardiovascular disease, considering the confounding effect of body fat. The results showed that the association between leptin and heart function and subclinical cardiovascular disease was attenuated after adjusting for body fat. The relationship between genetically-determined leptin concentration and coronary heart disease risk was inconclusive.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Rheumatology
S. van Beest, M. Kloppenburg, F. R. Rosendaal, L. A. van de Stadt
Summary: This study aimed to investigate the determinants of hand strength in patients with hand osteoarthritis (OA). The results showed that hand strength was negatively associated with female sex, age, and pain. It was found that subluxation of the first carpometacarpal joint (CMC1) was associated with reduced grip strength, while the associations with other radiographic features were confounded by age. The analysis also revealed that the severity of radiographic hand OA did not play an important mediating role in the relationship between age and hand strength.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Nursing
Bob Siegerink, Lodewijk A. Pet, Frits R. Rosendaal, Jan W. Schoones
NURSE EDUCATION IN PRACTICE
(2023)
