Article
Neuroimaging
Suraya Meghji, Alicia J. Hilderley, Kara Murias, Brian L. Brooks, John Andersen, Darcy Fehlings, Nomazulu Dlamini, Adam Kirton, Helen L. Carlson
Summary: Perinatal stroke is an early brain vascular injury that often leads to lifelong disability. Children with perinatal stroke commonly have comorbidities such as attention-deficit hyperactivity disorder (ADHD) and deficits in executive function. This study found differences in functional connectivity within and between networks in children with perinatal stroke, and these differences were associated with ADHD symptoms and executive function.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Psychology, Biological
Marta Korom, Alexandra R. Tabachnick, Tabitha Sellers, Emilio A. Valadez, Nim Tottenham, Mary Dozier
Summary: Positive associations have been found between cortical thickness and measures of parasympathetic cardiac control in adults, indicating integration between neural and physiological indicators of stress regulation. This study investigates when this brain-body association arises in development and whether the direction of association and neuroanatomical localization vary across development.
Article
Neurosciences
Costanza Iester, Monica Biggio, Simone Cutini, Sabrina Brigadoi, Charalambos Papaxanthis, Giampaolo Brichetto, Marco Bove, Laura Bonzano
Summary: This study used fNIRS to investigate differences in functional cortical connectivity at rest linked to the time of the day. The results showed that there were significant differences in inter-hemispheric parietal cortices connectivity, with higher connectivity in the morning and intra-hemispheric fronto-parietal connectivity, with higher connectivity in the afternoon. Additionally, the questionnaire survey revealed higher scores for imaginative thinking in the afternoon compared to the morning. These findings suggest that there may be variations in brain connectivity and thought processes during resting-state at different times of the day.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Junhyung Kim, Yong-Ku Kim
Summary: Alzheimer's disease is the most common type of dementia, with depression being a risk factor for its development. While depression patients often recover without residual symptoms, late-life depression patients may show residual cognitive impairment. Understanding how risk factors impact the course of Alzheimer's disease is crucial for its management.
Article
Neurosciences
Caiting Gan, Lina Wang, Min Ji, Kewei Ma, Huimin Sun, Kezhong Zhang, Yongsheng Yuan
Summary: Impulse control disorders in Parkinson's disease may be related to misjudgment of rewards and inability to suppress inappropriate choices. Our study found significant asymmetry in functional connectivity in specific brain regions among PD patients with impulse control disorders, which are associated with reward processing and inhibitory control.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Gaelle E. Doucet, Loic Labache, Paul M. Thompson, Marc Joliot, Sophia Frangou
Summary: The study aimed to construct a reliable brain atlas derived from older participants, identifying and subdividing major RSNs with high spatial reproducibility. Results showed spatial differences in RSNs derived from older versus younger populations, leading to the creation of a novel age-appropriate brain atlas, Atlas55+, for late adulthood RSN studies.
Article
Psychology, Multidisciplinary
Sally Richmond, Richard Beare, Katherine A. Johnson, Katherine Bray, Elena Pozzi, Nicholas B. Allen, Marc L. Seal, Sarah Whittle
Summary: This study investigated the associations between normative parenting behaviors and the development of structural brain networks in late childhood. The results suggest that variations in parenting may influence the development of structural brain networks, providing further insights into the environmental influences on structural connectivity during development.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Alexandra M. Cross, Reshma Ramdajal, Lien Peters, Matthew R. J. Vandermeer, Elizabeth P. Hayden, Jan C. Frijters, Karen A. Steinbach, Maureen W. Lovett, Lisa M. D. Archibald, Marc F. Joanisse
Summary: This study investigated the relationship between different reading subskills and brain functional connectivity in children using resting-state fMRI. The findings revealed both positive and negative relationships between different reading subskills and brain functional connectivity, suggesting that different components of reading ability are influenced by distinct functional connections in the brain.
Review
Behavioral Sciences
Sabrina K. Syan, Carly McIntyre-Wood, Luciano Minuzzi, Geoffrey Hall, Randi E. McCabe, James MacKillop
Summary: The study reviewed 29 studies that consistently supported the association between obesity and differences in Rs-FC. Specifically, obesity/overweight was associated with DMN hypoconnectivity and salience network hyperconnectivity; increased Rs-FC between the hypothalamus and reward, limbic, and salience networks, as well as decreased Rs-FC between the hypothalamus and cognitive regions; increased power within regions related to inhibition/emotional reasoning; decreased nodal efficiency, degree centrality, and global efficiency.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Nutrition & Dietetics
Nicolas Guerithault, Samuel M. McClure, Chinedum O. Ojinnaka, B. Blair Braden, Meg Bruening
Summary: In this study, fMRI was used to investigate the differences in functional connectivity across cognitive networks at rest among college students with different levels of food security. The results suggest that food insecurity is associated with poorer executive function and altered functional connectivity in specific brain regions, which may contribute to executive function difficulties in college students.
Article
Psychology, Biological
Dan Cai, Meiqi Deng, Jiancheng Yu, Wenya Nan, Ada W. S. Leung
Summary: This study investigated the links between resting-state EEG in the frontal scalp region and executive functions (EFs) in children aged 7-9 years, finding that different EEG activities can predict distinct components of EFs. Specifically, alpha to theta power ratio (ATR) and beta to theta power ratio (BTR) during eyes-open resting state positively predicted inhibition, and beta to theta power ratio (BTR) during eyes-open resting state positively predicted planning, but no EEG features related to working memory were found.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Velia Cardin, Elena Kremneva, Anna Komarova, Valeria Vinogradova, Tatiana Davidenko, Elina Zmeykina, Petr N. Kopnin, Kira Iriskhanova, Bencie Woll
Summary: Sensory experience has an impact on both the sensory networks and association networks supporting cognitive processing in the brain. This study explored the influence of early deafness on the organization of resting-state networks and its relation to executive processing. Significant group differences were found in the connectivity between auditory network seeds and large-scale networks, particularly the somatomotor and salience/ventral attention networks. Differences in the connectivity of association networks, such as the salience/ventral attention and default-mode networks, between groups were also associated with behavioral performance in executive function tasks.
Article
Neurosciences
Ashley F. P. Sanders, Michael P. Harms, Sridhar Kandala, Scott Marek, Leah H. Somerville, Susan Y. Bookheimer, Mirella Dapretto, Kathleen M. Thomas, David C. Van Essen, Essa Yacoub, Deanna M. Barch
Summary: The human brain remains active during rest, and functional MRI signals reveal an intrinsic functional architecture. Functional networks undergo varying maturation patterns during childhood and adolescence, and measures of functional connectivity differ based on age. However, many aspects of these developmental patterns remain unresolved.
Article
Clinical Neurology
Tobin J. Ehrlich, Hanjoo Kim, Kelly A. Ryan, Scott A. Langenecker, Elizabeth R. Duval, Anastasia K. Yocum, Claudia Diaz-Byrd, Anna L. Wrobel, Olivia M. Dean, Sue M. Cotton, Michael Berk, Melvin G. McInnis, David F. Marshall
Summary: This study evaluated the relationship between childhood trauma and cognition in individuals diagnosed with bipolar disorder. It found that higher childhood trauma was associated with worse memory functioning in bipolar disorder patients. The study emphasizes the importance of understanding the long-term cognitive outcomes of childhood trauma in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Damion Demeter, Evan M. Gordon, Tehila Nugiel, AnnaCarolina Garza, Tyler L. Larguinho, Jessica A. Church
Summary: During childhood, neural systems supporting high-level cognitive processes undergo rapid growth and refinement, relying on successful coordination of activation across the brain. We identified four distinct hub categories in a large youth sample, each exhibiting more diverse connectivity profiles than adults. The split in youth hubs suggests a need for segregating sensory stimuli during rapid development of functional networks.
Article
Nutrition & Dietetics
Jun S. Lai, Shirong Cai, Bee Lan Lee, Keith M. Godfrey, Peter D. Gluckman, Lynette P. Shek, Fabian Yap, Kok Hian Tan, Yap Seng Chong, Choon Nam Ong, Michael J. Meaney, Anne Rifkin-Graboi, Birit F. P. Broekman, Mary F. F. Chong
Summary: Current study found that higher maternal plasma carotenoids concentrations, especially beta-cryptoxanthin, were positively associated with early offspring cognitive and motor development at 2 years old, but not at 4.5 years old. Further investigations are needed to explore if the prenatal influences sustain beyond early childhood.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Psychiatry
Anqi Qiu, Han Zhang, Changqing Wang, Yap-Seng Chong, Lynette P. Shek, Peter D. Gluckman, Michael J. Meaney, Marielle V. Fortier, Yonghui Wu
Summary: The study found that the canonical TGF-beta signaling pathway plays a modulatory role in linking prenatal maternal depressive symptoms and amygdala volumes from birth to 6 years of age, with genetic variants of TGF-beta RI being particularly important in this relationship.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Kai-Hsiang Chuang, Pei-Huan Wu, Zengmin Li, Kang-Hsing Fan, Jun-Cheng Weng
Summary: This study developed a deep learning network based on generative adversarial networks (GAN) to automatically correct coil inhomogeneity and extract the brain from different image contrasts without user intervention. Using various quantitative indices, it was shown that this method achieved high similarity to the reference target and had consistent performance across different datasets. These results highlight the potential of deep networks to integrate different postprocessing methods and adapt to different image contrasts.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jingwen Zhu, Anqi Qiu
Summary: This study constructed a multimodal brain atlas for a Chinese aging population, including T1, HARDI, and rs-fMRI atlases. Using spectral clustering, 20 brain functional networks were generated, and joint independent component analysis was used to explore coherent markers for aging and gender.
Article
Geriatrics & Gerontology
Xiaoqing Alice Zhou, Grace Ngiam, Lei Qian, Kornraviya Sankorrakul, Elizabeth J. Coulson, Kai-Hsiang Chuang
Summary: Degeneration of cholinergic neurons in the basal forebrain (BF) is a contributing factor to cognitive impairment. However, the volume changes measured by structural MRI in the BF do not directly reflect the changes in cholinergic neurons.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Jingwen Zhu, Anqi Qiu
Summary: This study used multi-modal MRI data to investigate the functional connectivity of the brain in adolescents and found that the IVFC of the triple and cerebellar networks plays a crucial role in cognitive, emotional, and psychopathological development during adolescence.
Article
Computer Science, Artificial Intelligence
Chaoqiang Liu, Fei Huang, Anqi Qiu
Summary: This study develops a Monte Carlo Ensemble Neural Network (MCENN) which takes advantage of 2D-slice CNN fast computation and ensemble approaches to improve CNN performance in the diagnosis of Alzheimer's Disease. The MCENN model incorporates one neural network learner and uses Monte Carlo sampling to generate possible classification decisions, overcoming the lack of 3D brain anatomical information in 2D-slice CNNs. The MCENN achieves high accuracy in AD classification and is insensitive to image resolution, making it suitable for clinical use. Rating: 8/10.
Article
Psychiatry
Jian Huang, Ai Peng Tan, Evelyn Law, Keith M. Godfrey, Anqi Qiu, Lourdes Mary Daniel, Marielle Fortier, Kok Hian Tan, Jerry Kok Yen Chan, David Cameron-Smith, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Michael J. Meaney, Jonathan Huang
Summary: This study found that higher levels of certain nutrient-related biomarkers in maternal preconception blood were associated with an increased risk of behavioral problems in infants. The study also found that an increase in preconception thiamine levels was associated with higher CBCL scores and a lower right subthalamic nucleus ODI.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Grohn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
Summary: Task-free functional connectivity in animal models is an important tool for studying connectivity phenomena. However, the lack of standardized protocols and analysis methods hampers result comparison and integration. In this study, the authors developed a standardized protocol, called StandardRat, for rat functional magnetic resonance imaging (fMRI) acquisition and analysis, which enhances the detection of functional connectivity patterns and promotes cooperation in neuroscience research.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Anqi Qiu, Chaoqiang Liu
Summary: This study aimed to explore the possible pathways from genetic and environmental risks to structural brain organization and psychopathology in adolescents. The findings showed that lower socioeconomic status was associated with lower structural connectivity in certain brain networks and more severe psychosis and internalizing problems in youth. Prematurity and birth weight were related to early-developed sensorimotor and subcortical networks. Increased parental psychopathology, decreased socioeconomic status, and school engagement were associated with elevated family conflict, psychosis, and externalizing behaviors in youth. Increased maternal substance use predicted increased developmental adversity, internalizing problems, and psychosis. However, polygenic risks for psychiatric disorders had moderate effects on brain structural connectivity and psychopathology in youth.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Jingwen Zhu, Daniel Margulies, Anqi Qiu
Summary: It has been found that fluctuations in fMRI data can reflect meaningful patterns of brain activity in the white matter. This study used resting-state fMRI from adolescents to investigate the formation of large-scale white matter functional gradients. The results showed gray-matter-like unimodal-to-transmodal and sensorimotor-to-visual gradients with specific cognitive associations, as well as a unique superficial-to-deep gradient with nonspecific cognitive associations. The formation of these functional gradients is likely influenced by both functional and structural mechanisms during adolescence.
Correction
Neurosciences
Anqi Qiu, Chaoqiang Liu
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Chenye Shen, Chaoqiang Liu, Anqi Qiu
Summary: Metabolic syndrome (MetS) is associated with stroke and neurodegenerative diseases, and this study explored the associations of brain morphology with MetS and brain aging due to MetS. The research found that increased cortical surface area, decreased thickness, and reduced volumes in certain brain areas were associated with MetS components. Obesity had the strongest impact on brain morphology. Participants with more severe MetS had older brain age, and patients with stroke, dementia, Parkinson's, and multiple sclerosis showed greater brain age than the metabolic aging group. The obesity-related brain morphology can be used for risk assessment of stroke and neurodegenerative diseases.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Computer Science, Artificial Intelligence
Jing Xia, Nanguang Chen, Anqi Qiu
Summary: This study proposes a multi-level and joint attention network for learning high-order representations of brain functional connectivities to predict different cognitive tasks. The experiments demonstrate the effectiveness of attention modules and identify specific and shared brain functional connectivities and regions. The joint attention module significantly improves the prediction of cognitive functions. The network outperforms existing machine learning techniques on the ABCD dataset.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Psychology, Developmental
Tommie Forslund, Pehr Granqvist, Marinus H. van IJzendoorn, Avi Sagi-Schwartz, Danya Glaser, Miriam Steele, Marten Hammarlund, Carlo Schuengel, Marian J. Bakermans-Kranenburg, Howard Steele, Phillip R. Shaver, Ulrike Lux, John Simmonds, Deborah Jacobvitz, Ashley M. Groh, Kristin Bernard, Chantal Cyr, Nancy L. Hazen, Sarah Foster, Elia Psouni, Philip A. Cowan, Carolyn Pape Cowan, Anne Rifkin-Graboi, David Wilkins, Blaise Pierrehumbert, George M. Tarabulsy, Rodrigo A. Carcamo, Zhengyan Wang, Xi Liang, Maria Kazmierczak, Paulina Pawlicka, Lilian Ayiro, Tamara Chansa, Francis Sichimba, Haatembo Mooya, Loyola McLean, Manuela Verissimo, Sonia Gojman-de-Millan, Marlene M. Moretti, Fabien Bacro, Mikko J. Peltola, Megan Galbally, Kiyomi Kondo-Ikemura, Kazuko Y. Behrens, Stephen Scott, Andres Fresno Rodriguez, Rosario Spencer, German Posada, Rosalinda Cassibba, Neus Barrantes-Vidal, Jesus Palacios, Lavinia Barone, Sheri Madigan, Karen Mason-Jones, Sophie Reijman, Femmie Juffer, R. Pasco Fearon, Annie Bernier, Dante Cicchetti, Glenn I. Roisman, Jude Cassidy, Heinz Kindler, Peter Zimmermann, Ruth Feldman, Gottfried Spangler, Charles H. Zeanah, Mary Dozier, Jay Belsky, Michael E. Lamb, Robbie Duschinsky
Summary: The article discusses problems related to the use of attachment theory and research in family courts and provides recommendations for application, emphasizing the importance of three attachment principles and assessments of caregiving behavior. Recommendations aim to guide supportive interventions and future interdisciplinary research collaboration.
ATTACHMENT & HUMAN DEVELOPMENT
(2022)