Article
Neurosciences
Maurizio Bergamino, Elizabeth G. Keeling, Leslie C. Baxter, Nicholas J. Sisco, Ryan R. Walsh, Ashley M. Stokes
Summary: The study investigates the differences in grey matter (GM) volume and white matter (WM) microstructural disorganization between males and females with Alzheimer's disease (AD) using voxel-based morphometry (VBM) and free-water-corrected diffusion tensor imaging (FW-DTI). The results show significant group and sex differences, and post-hoc comparisons reveal that AD is associated with reduced GM volume, reduced FW-FA, and higher FW-RD/FW-index, consistent with neurodegeneration. Females in both groups exhibit higher GM volume than males, while FW-DTI metrics show sex differences only in the AD group.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Louisa P. Selvadurai, Nellie Georgiou-Karistianis, Rosita Shishegar, Cathlin Sheridan, Gary F. Egan, Martin B. Delatycki, Ian H. Harding, Louise A. Corben
Summary: This study found evidence of earlier cerebellar and later cerebral degeneration in Friedreich ataxia progression, with individuals showing greater white matter volume loss in specific regions, depending on their severity of symptoms and age of disease onset. Additionally, changes in cerebral atrophy and axial diffusivity were observed in individuals with more severe symptoms, while progression in radial diffusivity was more pronounced in those with earlier disease onset.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rheumatology
Benjamin Mosch, Verena Hagena, Stephan Herpertz, Martin Diers
Summary: This study identified different types of brain morphometric changes in patients with fibromyalgia, including abnormalities in gray and white matter. These changes may affect areas related to sensory and affective pain processing. The study also found the influence of behavioral and clinical factors on structural changes.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Acoustics
R. Corroenne, D. Grevent, H. Mahallati, G. Gauchard, L. Bussieres, Y. Ville, L. J. Salomon
Summary: This study aimed to evaluate the feasibility of DTI of the spinal cord in utero and examine gestational-age-related changes in DTI parameters. The results showed that DTI of the spinal cord is feasible in normal fetuses and there is a significant GA-related change in FA in the fetal spinal cord during pregnancy.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Clinical Neurology
Jan J. A. van den Dorpel, Marjolein H. G. Dremmen, Nadine A. M. E. van der Beek, Dimitris Rizopoulos, Pieter A. van Doorn, Ans T. van der Ploeg, Ryan L. Muetzel, Johanna M. P. van den Hout
Summary: Enzyme replacement therapy has greatly improved the prognosis of patients with Pompe disease. Classic infantile patients show progressive white matter abnormalities, while the brain involvement in late-onset patients is still not well understood. This study used structural and diffusion tensor imaging (DTI) to examine the microstructure of white matter in classic infantile and late-onset Pompe patients. The results showed significant differences in FA and MD between classic infantile patients and a reference population, with large-association fibers being most affected. Late-onset patients did not show deviations from normal neurodevelopment. These findings suggest that DTI can be a promising tool for monitoring therapy response in Pompe patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Erin E. O'Connor, Thomas A. Zeffiro, Oscar L. Lopez, James T. Becker
Summary: The study found that while HIV infection has a localized effect on the striatal structure, having a prior ADI is a strong predictor of smaller global and regional GMV. HIV infection and ADI have independent effects on brain structure, without associated accelerated lower volume with age.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Neurosciences
Cindy H. Lee, Kristi L. Bartholomay, Matthew J. Marzelli, Jonas G. Miller, Jennifer L. Bruno, Amy A. Lightbody, Allan L. Reiss
Summary: This study investigated neuroanatomical differences in young females with fragile X syndrome compared to a matched control group. The results showed larger total gray and white matter volumes in girls with fragile X syndrome, as well as differences in specific brain regions. These findings provide insights into the gene-brain-behavior relationships underlying the fragile X syndrome phenotype in females and expand our understanding of the neurodevelopmental mechanisms in this condition.
Article
Behavioral Sciences
William D. S. Killgore, John R. Vanuk, Natalie S. Dailey
Summary: The study compared the effects of blue-light exposure treatment and amber light treatment on sleep in individuals with PTSD, finding that BLT increased total time in bed and total sleep time, while ALT improved wake after sleep onset and sleep efficiency, possibly correlated with increased amygdala volume.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Goeerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Duezel, Gabriel Ziegler
Summary: This study used voxel-based morphometry to validate the classification system of Alzheimer's disease biomarkers. The results showed that early amyloid conversion is associated with brain volume loss, supporting the monotonic progression model of the amyloid-tau-neurodegeneration (ATN) system.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Gastroenterology & Hepatology
Shuming Zhang, Fenrong Chen, Jiayu Wu, Chengxiang Liu, Guang Yang, Ruiqing Piao, Bowen Geng, Ke Xu, Peng Liu
Summary: The study identified differences in gray matter volume between patients with UC and healthy controls, with decreased GMV in several regions and increased GMV in others. These changes were predominantly found in active UC patients and were partially associated with levels of anxiety and depression and clinical stage.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Psychiatry
Miaomiao Yu, Xinyu Gao, Xiaoyu Niu, Mengzhe Zhang, Zhengui Yang, Shaoqiang Han, Jingliang Cheng, Yong Zhang
Summary: This article aimed to investigate the common and certain neural alterations in the structure and function of the brain in patients with ADHD through a comprehensive analysis of multiple neuroimaging studies. The study found abnormal changes in the structure and function of the brain in ADHD patients, which may be associated with the left superior frontal gyrus and the corpus callosum, serving as imaging metrics for ADHD patients in the future.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Yangying Kuang, Xiaojia Wu, Hua Lai, Zhigang Wang, Qiang Lei, Weijia Zhong, Ya Yang, Chen Deng, Zhiming Zhou
Summary: This study found that OHE patients had decreased volumes in all subregions of the corpus callosum, and the decreased fractional anisotropy of CC-5 was correlated with decreased VMHC in specific brain regions. Additionally, the FA values of CC-5 and the volumes of CC-3, CC-4, and CC-5 showed correlations with neuropsychological performance in OHE patients, indicating that impairment of interhemispheric white matter pathways may disrupt functional connectivity and neurocognitive performance.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Neurosciences
Tadashi Shiohama, Keita Tsujimura
Summary: This article discusses the neurological manifestations of congenital genetic disorders and the use of neuroimaging studies in diagnosing and evaluating these disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Christof Seiler, Tamar Green, David Hong, Lindsay Chromik, Lynne Huffman, Susan Holmes, Allan L. Reiss
Article
Neurosciences
Stefani O'Donoghue, Tamar Green, Judith L. Ross, Joachim Hallmayer, Xiaoyan Lin, Booil Jo, Lynne C. Huffman, David S. Hong, Allan L. Reiss
BIOLOGICAL PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Xianglong Zhang, David Hong, Shining Ma, Thomas Ward, Marcus Ho, Reenal Pattni, Zhana Duren, Atanas Stankov, Sharon Bade Shrestha, Joachim Hallmayer, Wing Hung Wong, Allan L. Reiss, Alexander E. Urban
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Genetics & Heredity
Iliana I. Karipidis, David S. Hong
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2020)
Editorial Material
Pediatrics
Iliana I. Karipidis, David S. Hong
Meeting Abstract
Psychology, Developmental
David S. Hong
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Article
Psychiatry
Jennifer L. Bruno, David S. Hong, Amy A. Lightbody, S. M. Hadi Hosseini, Joachim Hallmayer, Allan L. Reiss
Summary: Individuals with Fragile X syndrome who carry the BclI polymorphism of the glucocorticoid receptor gene NR3C1 may exhibit attenuated symptoms of anxiety/depression and externalizing behaviors, with structural neuroimaging data able to differentiate between genotypes. Key regions of anxiety/fear neurocircuitry play a significant role in distinguishing groups.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Lara C. Foland-Ross, Maureen Gil, Sharon Bade Shrestha, Lindsay C. Chromik, David Hong, Allan L. Reiss
Summary: Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males associated with cognitive, social and emotional characteristics. Brain structure differences in KS patients were found to be related to changes in thickness and surface area, with decreases in volume linked to surface area reductions and increases linked to differences in thickness.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Article
Clinical Neurology
Tamar Green, Shira Flash, Geeta Shankar, Sharon Bade Shrestha, Booil Jo, Megan Klabunde, David S. Hong, Allan L. Reiss
Summary: The absence or excess of an X chromosome has distinct effects on cognition and behaviors associated with ADHD, with X chromosome absence affecting attention, hyperactivity, executive function, and processing speed, and X chromosome excess affecting working memory.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Robert M. Califf, Celeste Wong, P. Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega
Summary: The study found that individuals with higher PHQ-9 scores included females, younger participants, people of color, and Hispanic ethnicity, while multiple measures of low SES were also associated with higher PHQ-9 scores. The results underscored that depression should be considered a comorbidity when addressing social determinants of health, and both elements should be taken into consideration when designing appropriate interventions.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Psychiatry
Philip B. Cawkwell, David S. Hong, John E. Leikauf
Summary: This systematic review examined the impact of cannabis use on brain structure, function, and neurodevelopment outcomes in adolescents and young adults with ADHD. The findings suggest that cannabis use may affect brain structure but does not have a detrimental impact on executive function tasks. Early-onset cannabis use may have adverse impacts on this population. Larger and longer-term studies are needed to further understand the effects of cannabis use in youth with ADHD.
HARVARD REVIEW OF PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Robert M. Califf, Celeste Wong, P. Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega
Summary: This study explored the relationship between PHQ-9 scores and various health and disease measures, finding higher scores were associated with female sex, younger age, compromised physical status, and certain chronic conditions. It also identified a range of comorbidities and active symptoms correlated with increasing PHQ-9 scores.
Article
Clinical Neurology
Julio C. Nunes, Megan K. Carroll, Kenneth W. Mahaffey, Robert M. Califf, P. Murali Doraiswamy, Sarah Short, Svati H. Shah, Susan Swope, Donna Williams, Adrian F. Hernandez, David S. Hong
Summary: The study analyzed the correlation between demographic and socioeconomic data with participants' GAD-7 anxiety scores, showing that female sex, younger age, Hispanic ethnicity, low SES, unemployment, low income, and less education were associated with higher anxiety scores, while Black race and older age were considered protective factors.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Tracy L. Jordan, Megan Klabunde, Tamar Green, David S. Hong, Judith L. Ross, Booil Jo, Allan L. Reiss
Summary: Turner syndrome (TS) is a neurogenetic disorder characterized by physical, cognitive, and social-emotional features, caused by the absence of an X chromosome in females. Girls with TS typically show strengths in verbal abilities and weaknesses in visuospatial processing, executive function, and social cognition. This study examined the long-term trajectories of cognitive and social-emotional domains in TS and found that girls with TS exhibited poorer performance in visuospatial processing, executive function, and social cognition compared to controls throughout childhood and adolescence. Exploratory analyses suggested that estrogen replacement therapy (ERT) may have some positive effects on cognitive function in TS. Further research is needed to investigate the potential impacts of ERT on cognitive and social-emotional development in TS.
HORMONES AND BEHAVIOR
(2023)
Article
Psychology, Developmental
Scott S. Hall, Matthew J. Riley, Robyn N. Weston, Jean-Francois Lepage, David S. Hong, Booil Jo, Joachim Hallmayer, Allan L. Reiss
Summary: Research shows that girls with Turner syndrome are more likely to exhibit gaze avoidance during social interactions with unfamiliar individuals, with this impairment particularly pronounced in girls with maternally retained X chromosomes, indicating a genomic imprinting effect. This suggests that social gaze avoidance could serve as a critical marker for early identification of social dysfunction in young girls with TS.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
