☆ 4.6 Article

An Additional Motor-Related Field in the Lateral Frontal Cortex of Squirrel Monkeys

CEREBRAL CORTEX (2008)

Journal

CEREBRAL CORTEX

Volume 18, Issue 12, Pages 2719-2728

Publisher

OXFORD UNIV PRESS INC

DOI: 10.1093/cercor/bhn050

Keywords

-

Categories

Neurosciences

Funding

Canadian Institutes of Health Research fellowship
National Institutes of Health [NS30853]
National Institute of Child Health and Human Development Center [HD02528]
Landon Center on Aging

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Our earlier efforts to document the cortical connections of the ventral premotor cortex (PMv) revealed dense connections with a field rostral and lateral to PMv, an area we called the frontal rostral field (FR). Here, we present data collected in FR using electrophysiological and anatomical methods. Results show that FR contains an isolated motor representation of the forelimb that can be differentiated from PMv based on current thresholds and latencies to evoke electromyographic activity using intracortical microstimulation techniques. In addition, FR has a different pattern of cortical connections compared with PMv. Together, these data support that FR is an additional, previously undescribed motor-related area in squirrel monkeys.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Neurosciences

Visual responses in the dorsolateral frontal cortex of marmoset monkeys

Azadeh Feizpour, Piotr Majka, Tristan A. Chaplin, Declan Rowley, Hsin-Hao Yu, Elizabeth Zavitz, Nicholas S. C. Price, Marcello G. P. Rosa, Maureen A. Hagan

Summary: The marmoset monkey is emerging as a new primate model for neurophysiology research, with advantages in accessing various physiological techniques due to its lissencephalic cortex. Research on the visual behavior circuitry in marmosets is ongoing, with evidence of brisk visual responses in the dorsolateral prefrontal cortex. This suggests that the marmoset model may provide valuable insights into the study of visuomotor cognition.

JOURNAL OF NEUROPHYSIOLOGY (2021)

Add to Collection

Article Neurosciences

Frontal eye fields in macaque monkeys: prefrontal and premotor contributions to visually guided saccades

Kaleb A. Lowe, Wolf Zinke, Joshua D. Cosman, Jeffrey D. Schall

Summary: This study investigated the neuronal spiking modulation patterns in the FEF and F2vr areas of macaque monkeys. The results showed differences in the variety of modulation patterns, proportions of visuomotor neuron types, and consistency of modulation patterns across tasks between FEF and F2vr.

CEREBRAL CORTEX (2022)

Add to Collection

Article Neurosciences

Functional imaging and anatomical connections in squirrel monkeys reveal parietal-frontal circuits underlying eye movements

Iwona Stepniewska, Sofia Kahler-Quesada, Jon H. Kaas, Robert M. Friedman

Summary: The posterior parietal cortex (PPC) of squirrel monkeys contains subregions that can elicit complex movements. Stimulation of a specific area in the PPC, known as the parietal eye field (PEF), can induce eye movements. In this study, connections between PEF, frontal eye field (FEF), and other cortical regions were investigated in squirrel monkeys. The findings suggest that PEF in squirrel monkeys is similar to the lateral intraparietal (LIP) area in macaques in terms of its organization and function.

CEREBRAL CORTEX (2023)

Add to Collection

Article Neurosciences

Cortical Serotonergic and Catecholaminergic Denervation in MPTP-Treated Parkinsonian Monkeys

Gunasingh Jeyaraj Masilamoni, Allison Weinkle, Stella M. Papa, Yoland Smith

Summary: This study found decreased serotonergic and catecholaminergic innervation in the frontal cortex at early stages of Parkinson's disease. The use of MPTP-treated monkeys as animal models revealed that these changes may contribute to early non-motor symptoms in PD.

CEREBRAL CORTEX (2022)

Add to Collection

Review Neurosciences

Submillimeter fMRI reveals an extensive, fine-grained and functionally-relevant scene-processing network in monkeys

Xiaolian Li, Qi Zhu, Wim Vanduffel

Summary: This study reveals a more complex visual scene processing network in macaques compared to previous studies, with multiple functionally interconnected patches distributed across all cortical lobes.

PROGRESS IN NEUROBIOLOGY (2022)

Add to Collection

Article Neurosciences

Common fronto-temporal effective connectivity in humans and monkeys

Francesca Rocchi, Hiroyuki Oya, Fabien Balezeau, Alexander J. Billig, Zsuzsanna Kocsis, Rick L. Jenison, Kirill V. Nourski, Christopher K. Kovach, Mitchell Steinschneider, Yukiko Kikuchi, Ariane E. Rhone, Brian J. Dlouhy, Hiroto Kawasaki, Ralph Adolphs, Jeremy D. W. Greenlee, Timothy D. Griffiths, Matthew A. Howard, Christopher I. Petkov

Summary: This study found comparable effective connectivity patterns between macaque monkeys and humans in brain pathways supporting language and memory, with human-specific differences in hemispheric lateralization effects. Additionally, rapid evoked potentials were observed between the auditory cortex and VLPFC in humans, indicating direct projections similar to those seen in monkeys.

NEURON (2021)

Add to Collection

Article Multidisciplinary Sciences

Morphological changes of large layer V pyramidal neurons in cortical motor-related areas after spinal cord injury in macaque monkeys

Yu Takata, Hajime Yamanaka, Hiroshi Nakagawa, Masahiko Takada

Summary: Neurons in various motor-related areas of the frontal lobe have been found to vary in morphology in relation to the corticospinal tract (CST) in primates. This study investigates the changes in basal dendrite morphology of CST neurons after spinal cord injury (SCI) in macaque monkeys. It was observed that basal dendrite complexity and spine density were significantly decreased after SCI, with the changes being less prominent in the premotor cortex dorsolateral (PMd) region compared to other motor-related areas. These plastic changes in CST neurons may contribute to the recovery of motor functions following SCI.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Neurosciences

Depression induced by low-frequency repetitive transcranial magnetic stimulation to ventral medial frontal cortex in monkeys

Shinya Nakamura, Yodai Kishimoto, Masaki Sekino, Motoaki Nakamura, Ken-Ichiro Tsutsui

Summary: Using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) to inhibit neural activity in the ventral region of the medial frontal cortex (vMFC), this study found that the vMFC plays a causal role in regulating mood and the LF-rTMS-induced dysfunction of the vMFC serves as a valid nonhuman primate model of depression. The study also demonstrated that LF-rTMS targeting the vMFC induced depression-like symptoms in monkeys, including reduced movement activity, impaired sociability, decreased motivation, and increased plasma cortisol level.

EXPERIMENTAL NEUROLOGY (2022)

Add to Collection

Article Neurosciences

Impairment of bimanual in-phase movement during recovery from frontal lobe tumor surgery: a case report

Kozue Takada, Takuya Yamaguchi, Yuko Hyuga, Yuto Mitsuno, Satoshi Horiguchi, Masako Kinoshita, Takeshi Satow

Summary: This study evaluated the clinical features of bimanual movement impairment in a patient following surgery for a frontal lobe tumor. The results showed that resection of the frontal lobe can cause transient impairment of in-phase bimanual movement, and auditory cueing can improve bimanual movement performance.

FRONTIERS IN NEUROSCIENCE (2023)

Add to Collection

Article Neurosciences

Cerebellar outputs contribute to spontaneous and movement-related activity in the motor cortex of monkeys

Nobuya Sano, Yoshihisa Nakayama, Hiroaki Ishida, Satomi Chiken, Eiji Hoshi, Atsushi Nambu, Yukio Nishimura

Summary: Cerebellar outputs from the dentate nucleus (DN) influence activity in the primary motor cortex (M1) during both spontaneous and movement-related activity. Different types of M1 neurons show varied responses to DN stimulation, with facilitation- and suppression-type neurons exhibiting higher firing rates compared to no-response-type neurons during arm reaching tasks. Pharmacological inactivation of the DN reduces both spontaneous firing rates and movement-related activity in the M1.

NEUROSCIENCE RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys

Tingting Bo, Jie Li, Ganlu Hu, Ge Zhang, Wei Wang, Qian Lv, Shaoling Zhao, Junjie Ma, Meng Qin, Xiaohui Yao, Meiyun Wang, Guang-Zhong Wang, Zheng Wang

Summary: Integrative analyses of transcriptomic and neuroimaging data in cynomolgus macaques reveal the link between brain-wide gene expression and regional variation in morphometry, providing a unique resource to study nonhuman primate models of human diseases and explore cross-species evolutionary mechanisms.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima

Summary: This study found that Disulfiram produces anxiolytic-like effects in rodents by inhibiting the presynaptic inhibitory effects on glutaminergic neurons. Unlike diazepam, Disulfiram does not have adverse effects and may be an effective novel anxiolytic drug.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Neurosciences

The cortical connectome of primate lateral prefrontal cortex

Rui Xu, Narcisse P. Bichot, Atsushi Takahashi, Robert Desimone

Summary: This study reveals the connectivity between the lateral prefrontal cortex (LPFC) and the rest of the cortex. The results show isomorphic mappings between LPFC and other major processing domains, suggesting LPFC's role in coordinating activity within and across these domains.

NEURON (2022)

Add to Collection

Article Multidisciplinary Sciences

Echolocation-related reversal of information flow in a cortical vocalization network

Francisco Garcia-Rosales, Luciana Lopez-Jury, Eugenia Gonzalez-Palomares, Johannes Wetekam, Yuranny Cabral-Calderin, Ava Kiai, Manfred Koessl, Julio C. Hechavarria

Summary: This study investigates the dynamic information flow between cortical areas during vocalization using bats as a model, revealing that oscillation patterns can predict the purpose of vocalization and the information flow can change based on the behavioral role of vocalization.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Neurosciences

Stimulus Contrast Affects Spatial Integration in the Lateral Geniculate Nucleus of Macaque Monkeys

Darlene R. Archer, Henry J. Alitto, W. Martin Usrey

Summary: Stimulus contrast affects spatial integration in the lateral geniculate nucleus, resulting in reduced extraclassical surround suppression and larger preferred stimulus size with low-contrast stimuli. Effects are more pronounced in magnocellular neurons, suggesting stream-specific interactions between stimulus contrast and size. Contrast-dependent effects are comparable in ON-center and OFF-center neurons within the magnocellular pathway, indicating differential interactions between stimulus contrast and size to improve stimulus detection and discrimination under pathway-specific contrast conditions.

JOURNAL OF NEUROSCIENCE (2021)

Add to Collection

Article Clinical Neurology

Intracortical Microstimulation Parameters Dictate the Amplitude and Latency of Evoked Responses

Meghan Watson, Numa Dancause, Mohamad Sawan

BRAIN STIMULATION (2016)

Add to Collection

Article Neurosciences

Modulatory Effects of the Ipsi and Contralateral Ventral Premotor Cortex (PMv) on the Primary Motor Cortex (M1) Outputs to Intrinsic Hand and Forearm Muscles in Cebus apella

Stephan Quessy, Sandrine L. Cote, Adjia Hamadjida, Joan Deffeyes, Numa Dancause

CEREBRAL CORTEX (2016)

Add to Collection

Article Neurosciences

Different Patterns of Cortical Inputs to Subregions of the Primary Motor Cortex Hand Representation in Cebus apella

Melvin Dea, Adjia Hamadjida, Guillaume Elgbeili, Stephan Quessy, Numa Dancause

CEREBRAL CORTEX (2016)

Add to Collection

Article Clinical Neurology

Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1

Ralf Schirrmacher, Melvin Dea, Wolf-Dieter Heiss, Alexey Kostikov, Thomas Funck, Stephan Quessy, Barry Bedell, Numa Dancause, Alexander Thiel

CEREBROVASCULAR DISEASES (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Parallel Cortical Networks Formed by Modular Organization of Primary Motor Cortex Outputs

Adjia Hamadjida, Melvin Dea, Joan Deffeyes, Stephan Quessy, Numa Dancause

CURRENT BIOLOGY (2016)

Add to Collection

Article Neurosciences

Contrasting Modulatory Effects from the Dorsal and Ventral Premotor Cortex on Primary Motor Cortex Outputs

Sandrine L. Cote, Adjia Hamadjida, Stephan Quessy, Numa Dancause

JOURNAL OF NEUROSCIENCE (2017)

Add to Collection

Article Neurosciences

Modulatory effects of the supplementary motor area on primary motor cortex outputs

Sandrine L. Cote, Guillaume Elgbeili, Stephan Quessy, Numa Dancause

JOURNAL OF NEUROPHYSIOLOGY (2020)

Add to Collection

Article Neurosciences

Interhemispheric modulations of motor outputs by the rostral and caudal forelimb areas in rats

Boris Touvykine, Guillaume Elgbeili, Stephan Quessy, Numa Dancause

JOURNAL OF NEUROPHYSIOLOGY (2020)

Add to Collection

Article Engineering, Biomedical

Hierarchical Bayesian Optimization of Spatiotemporal Neurostimulations for Targeted Motor Outputs

Samuel Laferriere, Marco Bonizzato, Sandrine L. Cote, Numa Dancause, Guillaume Lajoie

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (2020)

Add to Collection

Article Clinical Neurology

Advancing Stroke Recovery Through Improved Articulation of Nonpharmacological Intervention Dose

Kathryn S. Hayward, Leonid Churilov, Emily J. Dalton, Amy Brodtmann, Bruce C. V. Campbell, David Copland, Numa Dancause, Erin Godecke, Tammy C. Hoffmann, Natasha A. Lannin, Matthew W. McDonald, Dale Corbett, Julie Bernhardt

Summary: The challenges of articulating dose in nonpharmacological stroke recovery research include the absence of specific internationally agreed dose reporting guidelines, inadequate conceptualization of dose, and unclear and inconsistent terminology. To address these challenges, a consistent approach to dose articulation is needed to stimulate critical thinking during intervention development and improve the accuracy of reported intervention doses.

STROKE (2021)

Add to Collection

Article Neurosciences

A machine learning approach to characterize sequential movement-related states in premotor and motor cortices

Michael DePass, Ali Falaki, Stephan Quessy, Numa Dancause, Ignasi Cos

Summary: The study examines the potential of using local field potentials (LFPs) to decode sequential movements involving motor preparation, execution, and reward retrieval in nonhuman primates. Through machine learning classifiers, the researchers were able to distinguish different movement-related states using LFPs with high accuracy. The results demonstrate the heterogeneity of neural activity and highlight the usefulness of micro-electrode array recordings for complex movement decoding. The findings suggest that high-dimensional LFPs could become the gold standard for brain-computer interfaces in the future.

JOURNAL OF NEUROPHYSIOLOGY (2022)

Add to Collection

Article Clinical Neurology

Enriched Rehabilitation Reduces Abnormal Motor Synergies and Enhances Motor Plasticity Following Severe Stroke in Rats

Gustavo Balbinot, Boris Touvykine, Joyce Zaftis, Clarissa Pedrini Schuch, Matthew Strider Jeffers, Guillaume Elgbeili, Numa Dancause, Dale Corbett

Summary: This study investigated the mechanisms of poststroke recovery using behavioral and kinematic analyses. The results showed that enriched rehabilitation can improve motor function recovery by restoring the function of motor-related structures. This study is important for understanding the process of motor recovery and identifying targets for optimizing poststroke recovery.

STROKE (2023)

Add to Collection

Article Rheumatology

Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo

Gladys Valverde-Franco, Bertrand Lussier, David Hum, Jiangping Wu, Adjia Hamadjida, Numa Dancause, Hassan Fahmi, Mohit Kapoor, Jean-Pierre Pelletier, Johanne Martel-Pelletier

ARTHRITIS RESEARCH & THERAPY (2016)

Add to Collection

Article Clinical Neurology

The Effect of Lesion Size on the Organization of the Ipsilesional and Contralesional Motor Cortex

Boris Touvykine, Babak K. Mansoori, Loyda Jean-Charles, Joan Deffeyes, Stephan Quessy, Numa Dancause

NEUROREHABILITATION AND NEURAL REPAIR (2016)

Add to Collection

Article Clinical Neurology

Effects of Subdural Monopolar Cortical Stimulation Paired With Rehabilitative Training on Behavioral and Neurophysiological Recovery After Cortical Ischemic Stroke in Adult Squirrel Monkeys

Erik J. Plautz, Scott Barbay, Shawn B. Frost, Elena V. Zoubina, Ann M. Stowe, Numa Dancause, Ines Eisner-Janowicz, Scott D. Bury, Michael D. Taylor, Randolph J. Nudo

NEUROREHABILITATION AND NEURAL REPAIR (2016)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.