Article
Clinical Neurology
Esmee Verburgt, Esther Janssen, Mina Jacob, Mengfei Cai, Annemieke Ter Telgte, Kim Wiegertjes, Roy P. C. Kessels, David G. Norris, Jose Marques, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: Small hyperintense lesions on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD) are found to be associated with the radiological progression of SVD and cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Laurent Puy, Marco Pasi, Mark Rodrigues, Susanne J. van Veluw, Georgios Tsivgoulis, Ashkan Shoamanesh, Charlotte Cordonnier
Summary: Cerebral microbleeds (CMBs) are hypointense foci visible on MRI sequences, helpful in identifying the nature and severity of chronic small vessel disease. Harmonising MRI parameters is crucial for improving cross-study comparisons.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Sephira G. Ryman, Nicholas Shaff, Andrew Dodd, Stephanie Nitschke, Christopher Wertz, Kayla Julio, Gerson Suarez Cedeno, Amanda Deligtisch, Erik Erhardt, Henry Lin, Andrei Vakhtin, Kathleen L. Poston, Rawan Tarawneh, Sarah Pirio Richardson, Andrew Mayer
Summary: This study aimed to investigate cerebrovascular dysfunction in participants with Parkinson's disease (PD) compared to healthy controls (HC) using functional magnetic resonance imaging (fMRI) and vasodilatory challenges. The results showed that PD participants had reduced and delayed cerebrovascular reactivity, which may be associated with chronic hypoxia, neuroinflammation, and protein aggregation. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions in PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Peter Kuehnlein, Christian Mahnkopf, Jennifer J. Majersik, Brent D. Wilson, Marcel Mitlacher, David Tirschwell, W. T. Longstreth, Nazem Akoum
Summary: The study found that patients with ESUS had significantly higher atrial fibrosis compared to healthy controls and lacunar stroke patients. Atrial fibrosis >= 12% was associated with recurrent stroke, incident AF or both in ESUS patients, suggesting potential benefits of anticoagulation for this subgroup.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Aivi T. Nguyen, Naomi Kouri, Sydney A. Labuzan, Scott A. Przybelski, Timothy G. Lesnick, Sheelakumari Raghavan, Robert Reid, R. Ross Reichard, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Michelle M. Mielke, Dennis W. Dickson, Jonathan Graff-Radford, Melissa E. Murray, Prashanthi Vemuri
Summary: This study evaluated the association between neuroimaging measures of cerebrovascular disease (CVD) and neuropathologic CVD scales, finding that dMRI could serve as a meaningful surrogate for CVD assessment and suggesting the development of better quantitative measures using dMRI.
ACTA NEUROPATHOLOGICA
(2022)
Article
Endocrinology & Metabolism
Hanne Stotesbury, Patrick W. Hales, Melanie Koelbel, Anna M. Hood, Jamie M. Kawadler, Dawn E. Saunders, Sati Sahota, David C. Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba P. D. Inusa, Jo Howard, Subarna Chakravorty, Chris A. Clark, Fenella J. Kirkham
Summary: Using arterial spin labelling (ASL), this study quantified high venous signal in patients with sickle cell anemia (SCA) and explored its associations with arterial oxygen content, disease-modifying treatments, cerebral infarction, and cognitive performance. The findings suggest the usefulness of multiTI ASL in objectively quantifying and identifying markers of regional hemodynamic stress in patients with SCA.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Marco Egle, Saima Hilal, A. M. Tuladhar, Lukas Pirpamer, Edith Hofer, Marco Duering, James Wason, Robin G. Morris, Martin Dichgans, Reinhold Schmidt, Daniel Tozer, Christopher Chen, Frank-Erik De Leeuw, Hugh S. Markus
Summary: The study suggests that DTI measures, such as mean diffusivity (MD) median, are associated with cognition and can predict dementia risk across a range of SVD severity. DTI measures contribute to cognition, improve prediction models when added, and can predict dementia conversion, especially in severe SVD cases.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Physiology
Venkatagiri Krishnamurthy, Justin D. Sprick, Lisa C. Krishnamurthy, Jolie D. Barter, Aaminah Turabi, Ihab M. Hajjar, Joe R. Nocera
Summary: Cerebrovascular control and its integration with other physiological systems are crucial for maintaining brain function, with CVR playing a significant role in regulating cerebral blood flow. Understanding the physiological factors influencing CVR is essential for improving rehabilitation outcomes, but further research is needed to elucidate how to enhance CVR and its impact on patient prognosis and diagnosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Wataru Sako, Takashi Abe, Yuki Matsumoto, Kazumi Nakamura, Shotaro Haji, Yusuke Osaki, Masafumi Harada, Yuishin Izumi
Summary: This study identified networks related to each cognitive domain in Parkinson's disease using resting-state functional MRI. Six networks were associated with visuospatial-executive, naming, attention, language, abstraction, and orientation domains. Cerebellar lobule VII and Brodmann area 10 were highlighted as playing key roles in cognitive impairment in Parkinson's disease.
Article
Neurosciences
Monica Margoni, Davide Poggiali, Sofia Zywicki, Martina Rubin, Andrea Lazzarotto, Silvia Franciotta, Maria Giulia Anglani, Francesco Causin, Francesca Rinaldi, Paola Perini, Massimo Filippi, Paolo Gallo
Summary: The study found that atrophy in the red nucleus in early relapse-onset MS patients is associated with cerebellar and midbrain white matter lesions, possibly due to anterograde axonal degeneration starting from these regions. This suggests that RN atrophy could serve as a potential marker for neurodegeneration or cerebellar damage in RMS.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Raffaello Bonacchi, Alessandro Meani, Elisabetta Pagani, Olga Marchesi, Massimo Filippi, Maria A. Rocca
Summary: This study confirmed the relevance of cerebellar gray matter and connecting structures damage in explaining cognitive dysfunction and physical disability in multiple sclerosis patients. Data-driven MRI clustering analysis can improve our understanding of the correlation between MRI findings and clinical manifestations.
JOURNAL OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Tom Chambers, Richard Anney, Peter N. Taylor, Alexander Teumer, Robin P. Peeters, Marco Medici, Xavier Caseras, D. Aled Rees
Summary: The study found that a history of hypothyroidism was associated with significant reductions in cerebellar and pallidum gray matter volumes, partly mediated by increases in body mass index. It was also observed that polygenic scores for hypo- and hyperthyroidism had opposing influences on gray matter volumes, with no evidence of regional genetic pleiotropy with ADHD for either hypo- or hyperthyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychiatry
Isabel K. Schuurmans, Sander Lamballais, Runyu Zou, Ryan L. Muetzel, Manon H. J. Hillegers, Charlotte A. M. Cecil, Annemarie I. Luik
Summary: Depressive symptoms vary in severity and stability over time, and high late-life depressive symptoms have been linked to poor brain health. To better understand the relationship between depressive symptoms and brain health, this study examined depressive symptom trajectories in middle age. The findings suggest that the impact of depressive symptoms on brain health may only become significant later in life.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Surgery
Laleh Zarrinkoob, Anders Wahlin, Khalid Ambarki, Anders Eklund, Jan Malm
Summary: This study utilized 4D PC-MRI to quantify and map the distribution of blood flow in cerebral arteries before and after carotid endarterectomy. It was found that total cerebral blood flow increased after the surgery and the distribution of blood flow became more balanced postoperatively. Patients with collateral recruitment showed laterality in the middle cerebral artery before but not after the surgery, indicating hemodynamic disturbances in this territory. This noninvasive method provides valuable insights into the pathophysiology of cerebral hemodynamics in patients with carotid stenosis.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Endocrinology & Metabolism
Silvia Lanfranconi, Lorenzo Piergallini, Dario Ronchi, Gloria Valcamonica, Giorgio Conte, Elena Marazzi, Giulia Manenti, Giulio Andrea Bertani, Marco Locatelli, Fabio Triulzi, Nereo Bresolin, Elisa Scola, Giacomo Pietro Comi
Summary: Cerebral cavernous malformations (CCM) can cause various symptoms including cerebral hemorrhage, seizures, headaches, and neurological deficits. Research has shown that patients with KRIT1/CCM1 mutations have a higher risk of developing new CCMs and experiencing bleedings. Magnetic Resonance Imaging (MRI) revealed that the infratentorial region is more frequently affected in mutated individuals, while the brainstem is often unaffected in patients with negative genetic testing.
METABOLIC BRAIN DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Sol Kwon, Hae-Sun Suh, Chung-Mo Nam, Hye-Young Kang
Summary: This study aimed to identify the factors that motivate public compliance with the government's COVID-19 preventive recommendations. The severity of COVID-19 symptoms and the risk of infection were found to be the most influential health-related factors, while social consequences and the risk of spreading infection also played a role. Respondents' behavior varied based on their socioeconomic characteristics and COVID-19 experience.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Clinical Neurology
Han Kyu Na, Han-Kyeol Kim, Hye Sun Lee, Mina Park, Jae Hoon Lee, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyoo
Summary: By studying 272 participants with MRI and PET scans, we found that a high degree of temporal lobe perivascular space (EPVS) is associated with a higher likelihood of amyloid positivity in patients with Alzheimer's disease. This finding suggests that impaired perivascular drainage may be related to cerebral amyloidosis.
ANNALS OF NEUROLOGY
(2023)
Article
Oncology
Chang Ik Yoon, Hye Sun Lee, Soyoung Jeon, Dooreh Kim, Woo-Chan Park
Summary: This study aimed to clarify the relationship between adjuvant tamoxifen use and cataracts risk using a nationwide longitudinal population-based registry. The results showed that adjuvant tamoxifen was not a significant risk factor for increased cataracts diagnosis and surgery in patients with DCIS.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Clinical Neurology
Yeon-Suk Lee, Jae Hong Joo, Jaeyong Shin, Chung Mo Nam, Eun-Cheol Park
Summary: There is a significant association between smartphone overdependence and generalized anxiety disorder among South Korean adolescents. The risk for generalized anxiety disorder increases with the negative impact on social relationships and severity of overdependence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
Summary: This study aimed to investigate the differences in incidence of pancreatic cancer between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM). The results showed that the risk of pancreatic cancer was higher in the group with diabetes compared to the non-diabetes group, and the risk was higher in the NODM group than in the LSDM group, especially in men and patients in their 50s.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jang-Hyun Baek, Byung Moon Kim, Sang Hyun Suh, Hong -Jun Jeon, Eun Hyun Ihm, Hyungjong Park, Chang-Hyun Kim, Sang-Hoon Cha, Chi-Hoon Choi, Kyung Sik Yi, Jun-Hwee Kim, Sangil Suh, Byungjun Kim, Yoonkyung Chang, So Yeon Kim, Jae Sang Oh, Ji Hoe Heo, Dong Joon Kim, Hyo Suk Nam, Young Dae Kim
Summary: This study evaluated the efficacy of EmboTrap II in achieving first-pass recanalization and its impact on clinical outcomes. The results showed a high success rate of achieving first-pass effect with EmboTrap II, which was associated with favorable clinical outcomes in patients with cerebral infarction.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Hye Sun Lee, Jee Hye Han, Boyoung Joung, Sung Jin Kim
Summary: This study confirms an inverse dose-dependent association between serum 25-hydroxyvitamin D levels and elevated intraocular pressure (EIOP) in a large sample of 15,338 individuals. Each unit increase in serum 25-hydroxyvitamin D is associated with a 3% decrease in the odds of having EIOP. Compared to individuals deficient in 25-hydroxyvitamin D, those with insufficiency and sufficiency have a 28% and 49% lower odds of EIOP, respectively. Therefore, clinical assessment of intraocular pressure may be helpful in the treatment and prevention of glaucoma in patients with insufficient 25-hydroxyvitamin D.
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Juyeon Yang, Hyung-Mi Kim, Ji-Won Lee
Summary: This study investigated the association between dietary zinc intake and total deaths, cancer, and cardiovascular disease death. The results showed that dietary zinc intake was inversely associated with all-cause mortality and cardiovascular disease mortality, but not with cancer mortality. These findings suggest that recommending optimal dietary zinc intake is beneficial for human health.
Article
Cardiac & Cardiovascular Systems
Minyoul Baik, Hyo Suk Nam, Ji Hoe Heo, Hye Sun Lee, Young Dae Kim
Summary: This study investigated the association between atherosclerotic stenosis and LDL-C or ApoB levels in ischemic stroke patients, and whether there is a difference in the association according to preadmission statin use. The results showed that both LDL-C and ApoB levels were associated with stenosis location, and there was an interaction between pre-admission statin use and LDL-C level. ApoB was consistently associated with symptomatic ICAS, regardless of statin use.
Article
Medicine, General & Internal
Lan-Ju Lee, Seong-Youl Choi, Hye-Sun Lee, Sang-Woo Han
Summary: This study aimed to analyze the difference in independency enhancement between VR-based training for daily activities and cognitive and motor functional training in stroke patients. The results showed that after VR-based intervention, daily activities, cognitive function, and upper extremities function were improved. It was concluded that training for daily activities based on tasks with objectives was more effective when introduced early.
Article
Multidisciplinary Sciences
Minho Han, JoonNyung Heo, Il Hyung Lee, Joon Ho Kim, Hyungwoo Lee, Jae Wook Jung, In Hwan Lim, Soon-Ho Hong, Young Dae Kim, Hyo Suk Nam
Summary: We investigated the prognostic impact of central blood pressure (BP) on outcomes in patients with embolic stroke of undetermined source (ESUS), and evaluated the prognostic value of central BP according to ESUS subtype. Over a median of 45.8 months, 746 patients with ESUS were enrolled and followed up. Our findings showed that central BP can predict poor long-term prognosis in ESUS patients, especially those with the no cause ESUS subtype.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Hyungwoo Lee, Kijeong Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Sunghee Cho, Ji Hoe Heo
Summary: This retrospective observational study of 350 patients with basal ganglia infarction found that degeneration of the substantia nigra (SN) was associated with functional dependence or death at 3 months post-stroke. The presence of SN degeneration was significantly correlated with worse functional outcomes, indicating its potential as a predictive factor for poor stroke prognosis and a target for therapeutic interventions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Jun Young Lim, Young Min Kim, Hye Sun Lee, Jeonghyun Kang
Summary: A machine learning algorithm was developed to predict skeletal muscle gauge in colorectal cancer patients using clinical and inflammatory markers. The algorithm demonstrated superior performance compared to single variables in predicting low skeletal muscle gauge. This model can serve as a screening tool for assessing and intervening in muscle health during treatment.
Article
Health Care Sciences & Services
Hyun-Joung No, Young Chul Yoo, Young Jun Oh, Hye Sun Lee, Soyoung Jeon, Ki Hong Kweon, Na Young Kim
Summary: This study retrospectively analyzed the effects of sugammadex compared with neostigmine on postoperative recovery in patients with myasthenia gravis who underwent video-assisted thoracoscopic surgery. The study found that patients who received sugammadex had a significantly shorter postoperative hospital stay compared to those who received neostigmine.
JOURNAL OF PERSONALIZED MEDICINE
(2023)