Article
Neurosciences
Mehak M. Khan, Shuting Wu, Christopher H. Chen, Wade G. Regehr
Summary: Prolonged depolarization of deep cerebellar nuclei (DCN) neurons leads to slow and bidirectional spike frequency adaptation. The adaptation mechanism is mediated by a novel mechanism independent of calcium entry and Na1-activated potassium channels. This allows DCN neurons to linearly respond to rapid changes in the firing rate of Purkinje cells (PCs) but adapt to slow changes on long timescales.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Ramakrishnan Bhuvanasundaram, Joanna Krzyspiak, Kamran Khodakhah
Summary: The subthalamic nucleus (STN) is connected to the pontine nuclei (PN) via a disynaptic connection, and STN modulates the activity of PN neurons. STN sends robust functional projections to PN, which then propagate to the cerebellum. These findings have important implications for understanding motor control and Parkinson's disease symptoms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Peter P. Ujma, Orsolya Szalardy, Daniel Fabo, Lorand Eross, Robert Bodizs
Summary: Slow waves are major pacemakers of NREM sleep oscillations, mainly generated by cortical neurons. This study found that thalamic activity during slow waves is highly similar to scalp activity, with different frequency bands observed during downstates and upstates. These results suggest that thalamic activity is primarily driven by global cortical activity, while smaller thalamocortical neuron assemblies may initiate cortical oscillations.
Article
Clinical Neurology
Tomomi Tsunematsu, Sumire Matsumoto, Mirna Merkler, Shuzo Sakata
Summary: P-waves, known as an electrophysiological signature of rapid eye movement (REM) sleep, are also observed during non-REM (NREM) sleep. Recent studies have discovered that P-waves in NREM sleep are functionally coupled with hippocampal sharp wave ripples (SWRs). The waveform shapes and local neural ensemble dynamics of P-waves in NREM sleep are similar to those in REM sleep in a short timescale. However, the dynamics of mesopontine cholinergic neurons and the coupling of P-waves with SWRs differ between NREM and REM sleep.
Article
Neurosciences
Monica Betta, Giacomo Handjaras, Andrea Leo, Alessandra Federici, Valentina Farinelli, Emiliano Ricciardi, Francesca Siclari, Stefano Meletti, Daniela Ballotta, Francesca Benuzzi, Giulio Bernardi
Summary: EEG slow waves play a crucial role in regulating essential processes such as learning and sensory disconnection. They may involve complex interactions within and between cortical and subcortical structures. Moreover, simultaneous EEG-fMRI recordings show that slow waves are associated with specific hemodynamic changes in different brain regions.
Article
Multidisciplinary Sciences
Yoshinori S. Kawai
Summary: Brain waves of different frequencies (gamma to delta) are widely studied and believed to be a communication mechanism for specific functions. Cross-frequency coupling (CFC), involving the fastest gamma range as information carrier, is well-documented, but the phase-phase CFC via the slowest delta and theta waves is rarely described. Animal brainstem, including humans, which utilize the slowest waves, has rarely been reported for CFC. Harmonic rhythms of different frequencies can cross-couple to sustain robust consonance despite perturbations.
Article
Mathematics, Applied
Emel Khan, Soheil Saghafi, Casey O. O. Diekman, Horacio G. G. Rotstein
Summary: Several distinct entrainment patterns can occur in the FitzHugh-Nagumo model under external periodic forcing. Polyglot entrainment, characterized by multiple disconnected 1:1 entrainment segments, is observed when the unforced system is in the vicinity of a Hopf bifurcation. The emergence of polyglot entrainment is explained using phase-plane analysis and other dynamical system tools. Similar entrainment effects are also observed in other systems.
Article
Cell Biology
Niccolo P. Pampaloni, Irene Riva, Anna L. Carbone, Andrew J. R. Plested
Summary: The study shows that in addition to the previously known fast-acting AMPA receptors, slow AMPA receptors with prolonged activity are also expressed in the hippocampal CA1 region. These slow AMPA receptors may play a significant role in synaptic transmission, short-term potentiation, and triggering of action potentials.
Article
Neurosciences
Robert Schmidt, Jonas Rose, Vignesh Muralidharan
Summary: Our understanding of neural oscillations is shifting, with transient oscillations replacing sustained oscillations as the dominant view. These transient oscillations have been observed in various cognitive tasks and species, and recent developments have focused on their analysis, computational modeling, and functional roles.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Patrycja Orlowska-Feuer, Annette Elisabeth Allen, Timothy Matthew Brown, Hanna Jowita Szkudlarek, Robert James Lucas, Riccardo Storchi
Summary: Neurophysiological activity in the subcortical visual system shows fluctuations in infra-slow and fast oscillatory ranges, with the phase of infra-slow modulating fast beta/gamma oscillations. Genetic ablations reveal that infra-slow and fast oscillations interact uniquely, potentially guiding visual processing. This interaction may play a significant role in vision function and disruptions in these oscillatory behaviors could contribute to vision dysfunction in retinal dystrophy.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Physiology
Maxime Juventin, Valentin Ghibaudo, Jules Granget, Corine Amat, Emmanuelle Courtiol, Nathalie Buonviso
Summary: Respiration, as a possible body signal influencing brain dynamics, plays a fundamental role in perception, cognition, and emotion. Recent findings have demonstrated the crucial role of the olfactory system in transmitting the respiratory influence on the brain through the sensitivity of its receptor cells to nasal airflow. Slow and deep nasal breathing is crucial in stimulating the olfactory system and thereby influencing the brain. It is suggested that coordinating breathing regime and brain state in an olfacto-limbic-respiratory circuit can promote calm and relaxation.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Biochemical Research Methods
David Reyner-Parra, Gemma Huguet
Summary: This study explores the synchronization between neuronal circuits connected with unidirectional projections and finds that inputs with high coherence can entrain the network for a wider range of frequencies, leading to more effective communication. It also shows that faster oscillatory inputs are more effective in communication than inputs with similar frequency. Additionally, it demonstrates that pulsatile inputs can switch between attended inputs in selective attention.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Physics, Fluids & Plasmas
Leonardo Dalla Porta, Daniel M. Castro, Mauro Copelli, Pedro Carelli, Fernanda S. Matias
Summary: Studies suggest that brain signals exert bottom-up and top-down influences through distinct frequency bands, with theoretical models proposed for reproducing these effects. A simple two-network motif using spiking-neuron models and chemical synapses can exhibit feedforward and feedback influences through different frequency bands, allowing for directed influences to be studied at both the population and cellular levels.
Article
Multidisciplinary Sciences
Chenguang Zheng, Ernie Hwaun, Carlos A. Loza, Laura Lee Colgin
Summary: In a spatial memory task, place cell sequences during correct trials are longer, more temporally compressed, and develop a bias to replay paths to a goal location during rest periods, while this is not observed during error trials. The coordination of place cell sequences by theta rhythms and sharp wave-ripples may play a crucial role in the successful performance of the task.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Nan Zhu, Yiyuan Zhang, Xi Xiao, Yimeng Wang, Jiajia Yang, Laura Lee Colgin, Chenguang Zheng
Summary: This study found that hippocampal CA2 supports social memory and experiences increased slow gamma rhythms during social interactions. The coupling between CA2 and CA1 theta-slow gamma was enhanced during social exploration. Furthermore, CA1 slow gamma rhythms and sharp wave-ripples were associated with social memory retrieval.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neurosciences
Christian Waiblinger, Clarissa J. Whitmire, Audrey Sederberg, Garrett B. Stanley, Cornelius Schwarz
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Maik C. Stuettgen, Cornelius Schwarz
Article
Multidisciplinary Sciences
Maysam Oladazimi, Wieland Brendel, Cornelius Schwarz
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Shubhodeep Chakrabarti, Cornelius Schwarz
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Julian I. Hofmann, Cornelius Schwarz, Uwe Rudolph, Bernd Antkowiak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Behavioral Sciences
Arindam Bhattacharjee, Diljit Singh Kajal, Alessandra Patrono, Yiwen Li Hegner, Massimiliano Zampini, Cornelius Schwarz, Christoph Braun
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2020)
Article
Neurosciences
Yi Chen, Filip Sobczak, Patricia Pais-Roldan, Cornelius Schwarz, Alan P. Koretsky, Xin Yu
Article
Biochemistry & Molecular Biology
Matthias Kreuzer, Sergejus Butovas, Paul S. Garcia, Gerhard Schneider, Cornelius Schwarz, Uwe Rudolph, Bernd Antkowiak, Berthold Drexler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Sophie Laturnus, Adrian Hoffmann, Shubhodeep Chakrabarti, Cornelius Schwarz
Summary: The brainstem trigeminal nuclei were found to largely preserve the encoding properties of primary afferents, including local encoding and kinematic response fields. While Pr5 and Sp5i exhibited lower spike and information rates compared to TG, the information rate per spike was comparable. This suggests a commonality in transferring primary afferent information despite differences in assumed functions.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Maysam Oladazimi, Thibaut Putelat, Robert Szalai, Kentaro Noda, Isao Shimoyama, Alan Champneys, Cornelius Schwarz
Summary: The study reveals how microNewton forces at the tip of a rat's whisker are transmitted to primary afferents, affecting perceptual activities. By using high resolution videography and accurate measurements, it is found that the shape of the whisker acts as a filter for converting moments and robustly engaging primary afferents. A mathematical model based on Cosserat rod theory and friction model quantifies the relationship between kinematics and dynamics.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Shubhodeep Chakrabarti, Jithin Nambiar, Cornelius Schwarz
Summary: Rodents generate rhythmic whisking movements to explore their environment. Researchers established a whisking task in which mice altered their whisking trajectory in a goal-oriented manner to gain rewards. By adjusting whisker kinematics, mice were able to adapt to changes in target distance while maintaining a constant reward probability.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Neurosciences
Arindam Bhattacharjee, Christoph Braun, Cornelius Schwarz
Summary: The study investigated whether humans implement a temporally local coding scheme for perceptual decisions in the tactile system. The results showed that manipulating local pulse shape significantly affects psychophysical performance, suggesting the existence of temporally local coding in human tactile perception. Different kinematic layouts of pulses resulted in distinct differences in performance, indicating that temporally local coding may not be tuned to a unique kinematic variable.
Article
Neurosciences
Arindam Bhattacharjee, Cornelius Schwarz
Summary: Research indicates that humans are better at remembering local variables compared to global variables, especially when it comes to detecting pulsatile changes, emphasizing the importance of local variables in memory retention.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Sergejus Butovas, Cornelius Schwarz
Summary: The goal of cortical neuroprosthetics is to accurately implant sensory information into cortical networks. This study demonstrated that passive touch and active touch have different effects on the local field potential (LFP) responses to microstimulation in the barrel cortex. Active touch significantly suppressed the positive deflection of LFP responses. This finding suggests that the behavioral context should be considered when using neuroprostheses to stimulate cortical circuits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Todor V. Gerdjikov, Caroline G. Bergner, Cornelius Schwarz