Review
Medicine, General & Internal
Maria Albanese, Nicola Biagio Mercuri
Summary: Recently, monoclonal antibodies (mAbs) targeting CGRP or its receptor have been approved for prophylactic use in migraine. While their efficacy in treating headache pain is well-documented, little is known about their effects on preventing migraine aura. This paper reports two cases of patients experiencing complete disappearance or reduction of aura symptoms when taking Galcanezumab or Erenumab, respectively. It also provides an overview of the controversial relationship between cerebral spreading depression and CGRP, as well as the potential central role of these mAbs in the pathophysiology of migraine aura.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ilaria Frattale, Valeria Caponnetto, Alfonsina Casalena, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Giannapia Affaitati, Maria Adele Giamberardino, Stefano Viola, Amleto Gabriele, Francesca Pistoia, Davide Cerone, Carmine Marini, Simona Sacco, Raffaele Ornello
Summary: The study found that 80.2% of triptan users were triptan responders, while 63.7% were erenumab responders. The response to triptans was associated with the response to erenumab in the study, with a significant odds ratio for erenumab response in triptan users compared to non-users. Starting erenumab also improved triptan response in both erenumab responders and non-responders, suggesting potential benefits for migraine treatment.
JOURNAL OF HEADACHE AND PAIN
(2021)
Review
Clinical Neurology
Haidar Muhsen Al-Khazali, Samaira Younis, Zainab Al-Sayegh, Sait Ashina, Messoud Ashina, Henrik W. Schytz
Summary: Neck pain is a common symptom among patients with migraine, and it is more prevalent in patients with chronic migraine compared to episodic migraine. This study aimed to estimate the prevalence of neck pain in migraine patients and non-headache controls through systematic literature search and meta-analysis.
Review
Clinical Neurology
Alec Giakas, Kiersten Mangold, Anthony Androulakis, Noah Hyduke, Igor Galynker, Melinda Thiam, Guoshuai Cai, X. Michelle Androulakis
Summary: This study conducted a systematic review and meta-analysis on suicidal ideation, attempts, and death in patients with head, neck, and back pain. The findings showed that both migraine and neck/back pain patients have an elevated risk of suicidal ideation and attempt compared to healthy controls, with migraine patients having a particularly higher risk.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Bartlomiej Blaszczyk, Marcin Straburzynski, Mieszko Wieckiewicz, Slawomir Budrewicz, Piotr Niemiec, Martyna Staszkiewicz, Marta Waliszewska-Prosol
Summary: This study explores the relationship between alcohol consumption and primary headaches. The findings from systematic review and meta-analysis suggest an inverse correlation between alcohol consumption and migraine, while tension-type headache (TTH) is not associated with drinking. The observation that migraine patients avoid alcohol may explain this relationship, rather than alcohol having a protective role against migraine. Further studies with low risk of bias are needed to investigate the relationship between primary headaches and alcohol consumption.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Biochemistry & Molecular Biology
Maram H. Alshareef, Bayan Hashim Alsharif
Summary: This study investigated the prevalence of primary headache disorders and associated risk factors in Makkah. The results showed a high prevalence of headaches, particularly among young adults. Age, chronic diseases, work, caffeine consumption, and smoking were found to be associated with headaches. The prevalence of headaches in Makkah has increased compared to previous studies.
Article
Biochemistry & Molecular Biology
Elisa Rubino, Andrea Marcinno, Alberto Grassini, Elisa Maria Piella, Fabio Ferrandes, Fausto Roveta, Silvia Boschi, Aurora Cermelli, Salvatore Gallone, Lidia Savi, Innocenzo Rainero
Summary: Migraine is a common disorder with unsatisfactory response to acute pain-relieving therapies. Functional polymorphism in the TNF-alpha gene is associated with the efficacy of NSAID administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Carlo Baraldi, Flavia Lo Castro, Raffaele Ornello, Simona Sacco, Luca Pani, Simona Guerzoni
Summary: OnabotulinumtoxinA (BT-A) is a drug used for preventive treatment of chronic migraine. Its exact mechanism of action is still debated, but it is known to inhibit the release of inflammatory mediators and reduce activation of nerve fibers. Clinical trials have shown its efficacy, and recent findings have improved understanding of its pharmacological actions. This review summarizes the available data on BT-A and discusses its role in chronic migraine treatment.
Article
Medicine, General & Internal
Hee-Jin Im, Yoo-Ha Hong, Soo-Jin Cho
Summary: Neck pain is a common symptom among migraine patients, and its impact on headaches and contributing factors are unclear. This study aimed to investigate the disability caused by neck pain on headaches and factors linked to comorbid neck pain, including sleep-related variables. The study found that neck pain was present in 51.9% of migraine patients, with high disability observed in some patients. Factors such as medication days per month, severe disability of migraine, and excessive daytime sleepiness were significant predictors for the severe impact of headaches. The study also found a positive correlation between neck pain and higher monthly headache days, female gender, and likelihood of obstructive sleep apnea among migraine patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Alison M. Deighton, Linda A. Harris, Karissa Johnston, Shomari Hogan, Lynn A. Quaranta, Gilbert L'Italien, Vlad Coric
Summary: The evidence suggests that rates of switch and discontinuation (WCS) among triptan users are low, with many patients opting for alternative acute medications after their first refill. Patients may not see improvement in disability when switching between triptans or turning to traditional acute migraine treatments. Variability in healthcare settings, patient severity, and study design contribute to the heterogeneity across the synthesis.
Review
Clinical Neurology
Hashmat Ghanizada, Afrim Iljazi, Hakan Ashina, Thien Phu Do, Mohammad Al-Mahdi Al-Karagholi, Faisal Mohammad Amin, Messoud Ashina
Summary: Human models of migraine have been used for three decades to test trigger molecules, but the nocebo effects have not been systematically explored. A systematic review and meta-analysis showed a low nocebo response rate in randomised clinical trials using human models of migraine.
Article
Obstetrics & Gynecology
Benedetta Pasquini, Viola Seravalli, Silvia Vannuccini, Francesco La Torre, Pierangelo Geppetti, Luigi Iannone, Silvia Benemei, Felice Petraglia
Summary: In women with endometriosis, many experience headache, and about 53.4% of them are diagnosed with migraine. Among these, 18.6% have pure menstrual migraine, 45.7% have menstrually related migraine, and 35.7% have non-menstrual migraine. Patients with endometriosis and migraine are more likely to have dysmenorrhea and dysuria compared to those without migraine.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Medicine, General & Internal
Iwona Rosciszewska-Zukowska, Sabina Galiniak, Halina Bartosik-Psujek
Summary: The aim of this study was to assess the prevalence and characteristics of headaches in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs). The study found that more than half of MS patients experienced headaches, with the prevalence of migraines being almost three times higher than tension-type headaches. Migraines in MS patients had high severity and typical migraine characteristics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Mohammad Mohammadi, Samuel Berchi Kankam, Sadaf Salehi, Mobin Mohamadi, Aynaz Mohammadi, Seyed Reza Dehghani Firoozabadi, Vahid Shaygannejad, Omid Mirmosayyeb
Summary: This study aimed to assess the prevalence and odds of migraine in multiple sclerosis (MS) patients and investigate the potential factors that may influence these associations. The results show that approximately 24% of MS patients experience migraine, and they have a 1.96-fold increased odds of having migraine compared to healthy individuals.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Sun-Young Oh, Jin-Ju Kang, Hong-Kyun Park, Soo-Jin Cho, Yuha Hong, Heui-Soo Moon, Mi Ji Lee, Tae-Jin Song, Yong-Jin Im, Won Jeong Son, Yun Ho Roh, Min Kyung Chu
Summary: The clinical features of patients with medication-overuse headache (MOH) differ according to the class of overused medications. Patients who overused multiple drug classes reported more frequent use of acute medications and fewer crystal-clear days, as well as shorter intervals from chronic daily headache to the onset of MOH and more emergency room visits. These findings contribute to the understanding of the clinical characteristics and pathophysiology of MOH.
Article
Clinical Neurology
Kristian Thorlund, Kabirraaj Toor, Ping Wu, Keith Chan, Eric Druyts, Elodie Ramos, Rahul Bhambri, Anne Donnet, Richard Stark, Peter J. Goadsby
Article
Clinical Neurology
Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward J. Mills, Michel Lanteri-Minet, Stewart Tepper
JOURNAL OF HEADACHE AND PAIN
(2016)
Article
Psychiatry
Elodie Ramos, Martin St-Andre, Evelyne Rey, Driss Oraichi, Anick Berard
BRITISH JOURNAL OF PSYCHIATRY
(2008)
Article
Clinical Neurology
Steve H. Landy, Stewart J. Tepper, Edward Schweizer, Mary Almas, Elodie Ramos
Article
Clinical Neurology
Mary Almas, Stewart J. Tepper, Stephen Landy, Edward Schweizer, Elodie Ramos
Article
Clinical Neurology
Stephen H. Landy, Stewart J. Tepper, Theodore Wein, Edward Schweizer, Elodie Ramos
Article
Clinical Neurology
Rahul Bhambri, Vincent T. Martin, Younos Abdulsattar, Stephen Silberstein, Mary Almas, Anjan Chatterjee, Elodie Ramos
Article
Hematology
Elham Rahme, Guillaume Feugere, Caroline Sirois, Sean Weicker, Elodie Ramos
THROMBOSIS RESEARCH
(2013)
Editorial Material
Pharmacology & Pharmacy
Elodie Baumfeld Andre, Peter K. Honig
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Review
Public, Environmental & Occupational Health
Elodie Baumfeld Andre, Robert Reynolds, Patrick Caubel, Laurent Azoulay, Nancy A. Dreyer
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Review
Medicine, General & Internal
Rahul Bhambri, Jack Mardekian, Larry Z. Liu, Edward Schweizer, Elodie Ramos
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2015)
Article
Psychiatry
Elodie Ramos, Martin St-Andre, Anick Berard
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2010)
Review
Medicine, Research & Experimental
Anick Berard, Elodie Ramos
M S-MEDECINE SCIENCES
(2007)
Article
Pharmacology & Pharmacy
Elodie Ramos, Benjamin Ofori, Driss Oraichi, Anick Berard
JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
(2008)