Article
Clinical Neurology
Dolores Vilas, Sara Rubio, Mireia Gea, Jose Rios, Lourdes Ispierto, Maria Hernandez-Perez, Marti Pare, Monica Millan, Laura Dorado
Summary: Through transcranial ultrasound, it was found that patients with chronic migraines had a larger echogenicity area of the periaqueductal gray matter, lower intensity of echogenicity, and higher heterogeneity within this brainstem structure compared to patients with episodic migraines and controls. The echogenicity of the periaqueductal gray matter should be further investigated as a biomarker of migraine chronification.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Donghun Lee
Summary: This study investigated the changes in retinal blood flow in patients with vascular paralytic strabismus using OCTA. The results demonstrated that the foveal vessel density in the paralysis eye was significantly lower compared to the non-paralysis eye, and increased after recovery. In addition, the severity of deviation angle and ocular motor restriction were negatively correlated with foveal vessel density.
Article
Clinical Neurology
Yansong Li, Guoliang Chen, Jing Lv, Lei Hou, Zhao Dong, Rongfei Wang, Min Su, Shengyuan Yu
Summary: This study examined EEG microstates in migraine patients and found that microstate classes B and D had higher time coverage and occurrence in migraine patients compared to healthy controls, while microstate class C exhibited lower time coverage and occurrence. The duration of microstate class C was negatively correlated with headache-related disability in migraine patients. Microstate syntax analysis also revealed significant differences in transition probabilities between the two groups.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Surgery
Edoardo Raposio, Giorgio Raposio, Denise Del Duchetto, Erica Tagliatti, Katia Cortese
Summary: The study examined the microscopic and ultrastructural characteristics of arteries at trigger points in migraine patients, revealing anomalies in endothelial cells and vascular smooth muscle cells. These alterations suggest an active involvement of these arteries in the pathogenesis of migraine.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Medicine, General & Internal
Mira P. Fitzek, Elisabeth Storch, Lucas H. Overeem, Pia Kull, Maria Terhart, Kristin S. Lange, Uwe Reuter, Bianca Raffaelli
Summary: Hormonal contraception (HC) should be considered in the management of women with migraine. A survey in Germany revealed that gynecologists take into account the presence of migraine and limiting factors when prescribing combined oral contraception (COC), while they seem to be less concerned with migraine when prescribing progestogen monotherapy (PM).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Betel Tesfay, William Kristian Karlsson, Rogelio Dominguez Moreno, Debbie L. Hay, Anders Hougaard
Summary: The purpose of this study was to provide an overview of clinical studies on CGRP measurements in body fluids of migraine patients and to discuss the validity of CGRP measurement as a clinical biomarker of migraine. Several studies have reported increased CGRP levels in various body fluids of migraine patients, suggesting that CGRP may be a feasible biomarker. However, inconsistencies and methodological challenges in measuring CGRP levels exist. CGRP measurements may have potential as biomarkers for predicting response to migraine therapy.
CURRENT OPINION IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Qifu Li, Jialei Feng, Xinghe Zhang, Yanan Wang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Ling Zhao, Taipin Guo
Summary: This is a clinical trial in China that aims to evaluate the efficacy of contralateral acupuncture (CAT) in women with unilateral migraine without aura (MwoA). The study will compare CAT with ipsilateral acupuncture (IAT) and sham acupuncture. The primary outcome is the changes in days of migraine attacks, and secondary outcomes include frequency, intensity, duration of migraines, medication intake, quality of life, disability assessment, headache impact, and sleep quality. The data will be collected at baseline, end of treatment, and follow-up visits. The study has received ethics approval and the results will be published and presented at conferences.
Review
Clinical Neurology
Mohammad Al-Mahdi Al-Karagholi, Veberka Kalatharan, Peter Schunck Fagerberg, Faisal Mohammad Amin
Summary: Intravenous infusion of h-α-CGRP has been used to investigate migraine pathogenesis and cerebral hemodynamics for the last 30 years. Studies have shown that h-α-CGRP regulates vascular tone. By analyzing clinical studies, this systematic review found that h-α-CGRP infusion caused flushing, palpitation, warm sensation, changes in heart rate, blood pressure, blood flow velocity, and artery diameter. These vascular changes lasted from 20 to >120 minutes without any serious adverse events. The involvement of CGRP in systemic hemodynamics raises concerns about long-term CGRP blockade in migraine patients with and without cardiovascular complications.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
R. Messina, R. H. Christensen, I. Cetta, M. Ashina, M. Filippi
Summary: This systematic review provides a comprehensive overview of the mechanisms of actions of headache treatments and potential biomarkers of treatment response revealed by neuroimaging studies. The findings suggest that acupuncture, neuromodulation, and medication withdrawal therapies can improve headache by altering headache-affected brain areas. However, there is currently no clear evidence for the specific location of action for each treatment and no reliable imaging predictors of efficacy.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Medicine, General & Internal
Jason Charles Ray, Zhibin Chen, Georgia Ramsay, Jack Germaine, Elspeth J. Hutton
Summary: This study aims to assess the efficacy and safety of eptinezumab compared to intravenous lidocaine in the treatment of status migrainosus. The study will include 40 patients who will be randomly assigned to receive either eptinezumab or intravenous lidocaine. The primary outcome measure is the time from infusion until resolution of pain, and several secondary measures will also be evaluated, including changes in health resource utilization and patient reported outcomes of migraine disability. The study has been approved by the Human Research Ethics Committee and informed consent will be obtained from all participants.
Review
Pharmacology & Pharmacy
Yohannes W. Woldeamanuel, Robert P. Cowan
Summary: This study conducted a systematic review and quality assessment of computerized migraine diagnostic tools. A total of 41 studies were included, and the results showed variations in the accuracy of different tools. Improvements in random patient sampling, head-to-head comparison, and generalizability to other headache diagnoses are needed.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Medicine, General & Internal
Shoji Kikui, Yirong Chen, Ken Ikeda, Miki Hasebe, Keiko Asao, Takao Takeshima
Summary: This study investigates the association between migraine and psychiatric and somatic comorbidities in Japan. The results show that migraine patients have a higher prevalence of psychiatric and somatic comorbidities compared to non-migraine patients. The study provides insights into the comorbidities of migraine patients.
Review
Medicine, General & Internal
Sookyung Lee, Jiyoon Yeo, Sook-Hyun Lee, Yoon Jae Lee, Sangkwan Lee, In-Hyuk Ha
Summary: This study analyzed the distribution and healthcare utilization of patients with migraine in South Korea using data from 2010-2018. The study identified the treatments frequently used in Western and Korean medicine hospitals, as well as their frequency of use and costs. The findings can be used as a basis for relevant health policy decisions.
Article
Immunology
Tatiana Koudriavtseva, Svetlana Lorenzano, Maria Cellerino, Mauro Truglio, Marco Fiorelli, Caterina Lapucci, Giovanna D'Agosto, Laura Conti, Annunziata Stefanile, Silvana Zannino, Maria Maddalena Filippi, Antonio Cortese, Carlo Piantadosi, Marta Maschio, Andrea Maialetti, Edvina Galie, Marco Salvetti, Matilde Inglese
Summary: The objective of this observational study was to identify the most specific pro-coagulative/vascular factors for multiple sclerosis pathogenesis and to correlate them with brain hemodynamic abnormalities. The results showed that tissue-factor was one of the key variables in differentiating multiple sclerosis from controls and relapse from remission.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Leah M. Schumacher, Samantha G. Farris, J. Graham Thomas, Richard B. Lipton, Jelena Pavlovic, Angeliki Vgontzas, Dale S. Bond
Summary: Obesity and migraine often coexist, and poor sleep quality is common among individuals with comorbid migraine and obesity. This study evaluated the associations between migraine characteristics and sleep quality in women with comorbid migraine and overweight/obesity. The presence of phonophobia and greater monthly migraine days were associated with poorer sleep quality. Obesity severity did not independently affect sleep quality in this population. These findings can inform further research on the migraine-sleep link and guide clinical care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hebun Erdur, Joachim E. Weber, Anselm Angermaier, Stephan Kinze, Ali Sotoodeh, Claudia Gorski, Kerstin Bollweg, Stefanie Ernst, Farid Kandil, Janina Behrens, Ramanan Ganeshan, Anne Keysers, Malgorzata Kotlarz-Boettcher, Daniel Peters, Ludwig Schlemm, Kirsten Stangenberg-Gliss, Carl Witt, Beata Hennig, Katrin C. Reber, Udo Schneider, Christiana Franke, Ingo Schmehl, Hans-Beatus Straub, Agnes Floeel, Sarah Theen, Matthias Endres, Tobias Kurth, Heinrich J. Audebert
Summary: Implementing a multicomponent system-of-care can reduce the risk of poor outcomes in stroke patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Sofia Oliveira Goncalves, Jessica L. Rohmann, Marco Piccininni, Tobias Kurth, Martin Ebinger, Matthias Endres, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Reinhard Busse, Heinrich J. Audebert
Summary: The study assessed the cost-utility and cost-effectiveness of additional mobile stroke unit (MSU) dispatch in ischemic stroke patients eligible for recanalizing treatments. Results showed that MSU dispatch increased costs but also improved quality-adjusted life years (QALYs), and it was considered cost-effective according to internationally accepted thresholds.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tobias Kurth, Jessica L. Rohmann
Review
Economics
Ana Sofia Oliveira Goncalves, Sophia Werdin, Tobias Kurth, Dimitra Panteli
Summary: This review aimed to identify how studies deal with methodological challenges of repeated measurements in mapping algorithms using patient responses to questionnaires. The inconsistent use of methods to account for interdependent observations indicates a need for mapping guidelines and journal updates.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Health Care Sciences & Services
Jana Fehr, Marco Piccininni, Tobias Kurth, Stefan Konigorski
Summary: This study investigates the transportability of prediction models for cognitive impairment in different external settings. The results suggest that models predicting with causes of the outcome are more transportable than those predicting with consequences. Calibration performance is crucial when assessing model transportability to external settings.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Tobias Kurth, Heinrich J. Audebert, Jessica L. Rohmann
Summary: The B_PROUD study aimed to evaluate the impact of mobile stroke unit (MSU) dispatch on ischemic stroke and transient ischemic attack (TIA) patients. However, a large proportion of patients did not receive MSU care despite being dispatched. The study found that receiving additional MSU care was associated with better functional outcomes compared to conventional care.
Article
Cardiac & Cardiovascular Systems
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, Tobias Kurth
Summary: Adding information on migraine with aura (MA) to cardiovascular disease (CVD) risk prediction models can improve risk prediction accuracy, but does not significantly improve risk stratification among women.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Kurth, Pamela M. Rist
Summary: The connection between migraine and cardiovascular disease is intricate and involves overlapping mechanisms like endovascular disturbances. Challenges in measuring migraine, differentiating causation from prediction, and understanding clinical implications emphasize the importance of further research to guide treatment and cardiovascular risk assessment for migraine sufferers.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Clinical Neurology
Marco Piccininni, Ralph Brinks, Jessica L. Rohmann, Tobias Kurth
Summary: This study used modern epidemiological methods to estimate the prevalence of never, active, and inactive migraine. The transition rate from active to inactive migraine increased after age 22.5 for women and 27.5 for men in Germany. The estimated prevalence of inactive migraine at age 60 was 25.7% for women in Germany and 16.5% globally, and 10.4% for men in Germany and 7.1% globally.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Health Care Sciences & Services
Vanessa Voelskow, Claudia Messner, Tobias Kurth, Amelie Busam, Toivo Glatz, Natalie Ebert
Summary: During the COVID-19 pandemic in Germany, telephone hotlines of local health authorities were overwhelmed with information requests. This study evaluated the use of a COVID-19-specific voicebot (CovBot) in these authorities and found that while it provided some relief to staff, it could not fully replace human assistance.
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)