Article
Clinical Neurology
Gudrun Gossrau, Marie Frost, Anna Klimova, Thea Koch, Rainer Sabatowski, Coralie Mignot, Antje Haehner
Summary: This study investigated the relationship between sensitivity to olfactory stimuli and the clinical course of migraine. The results showed that patients with longer migraine duration and higher migraine-related impairment demonstrated increased sensitivity to odors during preictal, ictal, and interictal phases.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Omeed Partovi, Amir Soheil Tolebeyan
Summary: This report shows that migraine patients may present with different olfactory hallucination manifestations, some occurring before headaches and some persisting. Due to the clinical significance, it is suggested that ICHD classify this phenomenon as a subtype of aura in the future, but further larger studies are needed to better assess its pathophysiology.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Arife Cimen Atalar, Aynur Ozge, Bengi Gul Turk, Esme Ekizoglu, Duygu Kurt Gok, Betul Baykan, Semih Ayta, Fusun Ferda Erdogan, Seher Naz Yeni, Bahar Tasdelen, Sibel K. Velioglu
Summary: In this study, the diagnostic gaps in the diagnosis of comorbid migraine without aura (MwoA) in patients with idiopathic/genetic epilepsy (I/GE) were disclosed using a zone concept. Longer headache duration, throbbing pain, increase of pain by physical activity, photophobia and/or phonophobia, presence of vertigo/dizziness, osmophobia, and higher VAS scores were found to be the main associated factors for the comorbid MwoA diagnosis in patients with I/GEs.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Daniela D'Agnano, Salvatore Lo Cascio, Edvige Correnti, Vincenzo Raieli, Vittorio Sciruicchio
Summary: Since the first descriptions of visual hallucinations in migraine and occipital lobe epilepsy, recognizing epileptic seizures of the occipital lobe has become a challenge due to the similarities with migraine symptoms. Detailed clinical examination of visual impairment can help differentiate the two diseases, especially in children where overlaps are common. Understanding the distinctive features of visual aura in migraine and visual hallucinations in occipital epilepsy can provide insights into the underlying mechanisms of these conditions.
Review
Biology
Valentina Baglioni, Silvia Orecchio, Dario Esposito, Noemi Faedda, Giulia Natalucci, Vincenzo Guidetti
Summary: In pediatric neurology, tension-type headache (TTH) is a common primary headache among children. However, it is often underestimated and difficult to differentiate from secondary and other primary headaches in childhood. There can be clinical overlap between migraine and TTH in children, with migraine attacks presenting tension headache-like features and TTH displaying migraine-like symptoms. Factors such as hormonal changes, triggers, and genetic and epigenetic factors play a role in the complex trajectory of headache evolution. This review aims to summarize the literature on the differential diagnosis of TTH in pediatrics, the possible outcomes during development, and appropriate therapeutic strategies.
Review
Oncology
Carolyn A. Bernstein
Summary: This review article provides a comprehensive overview of headache evaluation and treatment in cancer patients, including the diagnostic process, common types of headaches, pharmacological treatment, and complementary and integrative therapies.
Article
Clinical Neurology
Isabella Neri, Daniela Menichini, Francesca Monari, Ludovica Spano Bascio, Federico Banchelli, Fabio Facchinetti
Summary: This study showed that pregnant women with migraine with aura and tension-type headache are at increased risk of delivering small for gestational age infants. Additionally, abnormal utero-placenta markers in the first trimester were associated with these headache disorders. Therefore, these women may require additional attention and interventions during pregnancy.
Article
Anesthesiology
Nermin Tanik, Murat Bektas
Summary: The study developed a valid and reliable scale to assess the impact of osmophobia on quality of life in migraine patients, which can be a practical diagnostic tool in clinical practice and research.
Review
Clinical Neurology
Roberta Messina, Cedric Gollion, Rune Hackert Christensen, Faisal Mohammad Amin
Summary: This review examines the use of fMRI to study the mechanisms of migraine. It finds that migraine attacks are associated with hypothalamic hyperexcitability and disruptions in the pain and central trigeminovascular pathways. The visual cortex also becomes hyperexcitable during the aura phase. Additionally, disruptions in the pontine, thalamic, sensorimotor, and visual networks are observed during the headache phase, while hypothalamic activity and connectivity normalize. The visual cortex remains hyperexcitable during the postdromal phase, and asymptomatic migraine patients also show functional alterations in pain and visual processing brain areas.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Rhannon Lobo, Mu Wang, Sean Lobo, Anish Bahra
Summary: New daily persistent headache is a challenging condition characterized by daily headache from onset. A study conducted in London found that most patients experienced chronic migraine, with a subset also experiencing thunderclap-onset headache. Factors like aura types, prior headache history, and premorbid disorders were also observed in the study cohort. Improvement was seen in a small percentage of patients, with some responding well to preventative medications like amitriptyline.
Article
Behavioral Sciences
Etedal Ahmed A. Ibrahim, Ghada A. Mutaal Badri, Khabab Abbasher Hussien Mohamed Ahmed, Mohammed Eltahier Abdalla Omer
Summary: The study found that environmental conditions were the most common triggers of migraine headache among Sudanese patients, while Acetaminophen was the most commonly used drug for relieving migraine in this population. The majority of patients were female (80%), aged 26-35 years (56.9%), and a significant proportion were housewives (40%).
BRAIN AND BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Paola Tiberio, Alessandro Vigano, Mariya Boyanova Ilieva, Sebastiano Pindilli, Anna Bianchi, Alberto Zambelli, Armando Santoro, Rita De Sanctis
Summary: Numerous epidemiological studies have explored the potential link between migraine and breast cancer due to their association with female reproductive hormones. Current evidence suggests a protective role of migraine in breast cancer development, particularly in case-control studies. However, the inconsistency among studies and recent research challenging this concept indicate a more complex relationship between the two conditions. Further studies are needed to validate the protective role of migraine in breast cancer and identify the precise nature of this causal relationship.
Article
Medicine, General & Internal
Iwona Rosciszewska-Zukowska, Sabina Galiniak, Halina Bartosik-Psujek
Summary: The aim of this study was to assess the prevalence and characteristics of headaches in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs). The study found that more than half of MS patients experienced headaches, with the prevalence of migraines being almost three times higher than tension-type headaches. Migraines in MS patients had high severity and typical migraine characteristics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Cinzia Cavestro, Giancarlo Prandi, Matteo Manildo, Sabina Martini, Corrado Genovesi, Alberto Premoli, Flavio Fraire, Loris Neri, Silvia Mandrino, Marcella Ferrero, Eugenia Rota
Summary: This study aimed to investigate the association between HP infection and headache, particularly migraine. The results showed no significant association between HP infection and migraine, but a significant association between HP infection and headache frequency.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Jawad H. Butt, Heidi S. Eddelien, Christina Kruuse
Summary: Sildenafil induces aura and migraine-like headache in patients with migraine with aura, supporting the dissociation between the aura and the headache phase.
Review
Psychology, Developmental
Veit Roessner, Heike Eichele, Jeremy S. Stern, Liselotte Skov, Renata Rizzo, Nanette Mol Debes, Peter Nagy, Andrea E. Cavanna, Cristiano Termine, Christos Ganos, Alexander Muenchau, Natalia Szejko, Danielle Cath, Kirsten R. Mueller-Vahl, Cara Verdellen, Andreas Hartmann, Aribert Rothenberger, Pieter J. Hoekstra, Kerstin J. Plessen
Summary: The first European guidelines for Tourette Syndrome (TS) were published in 2011 by the European Society for the Study of Tourette Syndrome (ESSTS). The updated part on pharmacological treatment emphasizes the importance of psychoeducation and behavioral approaches as first-line treatments. Pharmacological treatment, particularly with dopamine blocking agents like aripiprazole, is indicated in some patients, especially when behavioral approaches are not effective or feasible. Treatment should be individualized based on the patient's needs, preferences, and co-existing conditions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Pediatrics
Lea Lenglart, Vincenzo Raieli, Vittorio Sciruicchio, Caroline Caula, Giulia Vitali, Romain Guedj, Giuseppe Quatrosi, Daniela D'Agnano, Renato D'Alonzo, Thomas Moulding, Victoria Elisa Rinaldi, Luigi Titomanlio
Summary: This study is the first to find an association between migraine and infantile regurgitation in children. Subgroup analysis also revealed a relationship between functional dyspepsia, irritable bowel syndrome, and abdominal migraine with migraine without aura.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Clinical Neurology
Mariarita Capizzi, Giuseppe Quatrosi, Giovanna Martina Nocera, Fulvio Guccione, Luigi Vetri, Rosaria Nardello, Andrea Santangelo, Maurizio Elia, Salvatore Mangano, Filippo Brighina, Giuseppe Santangelo, Vincenzo Raieli
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Cristiano Termine, Linda Greta Dui, Laura Borzaga, Vera Galli, Rossella Lipari, Marta Vergani, Valentina Berlusconi, Massimo Agosti, Francesca Lunardini, Simona Ferrante
Summary: A cross-sectional study compared the effects of social distancing and lifestyle changes during the COVID-19 lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). Results showed that NDDs significantly impacted remote learning, sociality, scolding, and anxiety levels. There was agreement between parents and children regarding remote learning, lifestyle, and scolding. This study highlights the importance of supportive strategies for youth with NDDs during periods of lockdown.
CURRENT PSYCHOLOGY
(2023)
Review
Medicine, General & Internal
Vincenzo Raieli, Federica Reina, Daniela D'Agnano, Giovanna Martina Nocera, Mariarita Capizzi, Francesca Marchese, Vittorio Sciruicchio
Summary: Trochlear Migraine is characterized by strictly unilateral migraine and ipsilateral trochleodynia, with relief of migraine after successful treatment of trochleodynia. The term should be reserved for clinical migraine attacks strictly localized in the trochlear region.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Vincenzo Raieli, Mariarita Capizzi, Antonio Marino, Giovanni Di Nardo, Umberto Raucci, Pasquale Parisi
Summary: Migraine is a complex neurologic disorder that affects multiple systems of the central nervous system. Keeping an aura diary can help in diagnosing and preventing under-diagnosis of rare migraine manifestations. Complex migraine manifestations require a thorough diagnostic work-up to exclude dangerous neurologic pathologies.
Review
Neurosciences
Salvatore Lo Cascio, Edvige Correnti, Sofia D'Agostino, Mariarita Capizzi, Antonio Marino, Raffaele Meli, Salvatore Lo Nobile, Vincenzo Raieli
Summary: The presence of CAS in migraine, usually associated with trigeminal autonomic cephalalgias, has also been reported in adult and pediatric populations. Experimental evidence suggests that increased parasympathetic outflow can enhance the sensitization of nociceptive receptors involved in migraine. Identifying and understanding these symptoms in migraine may be crucial for diagnosis and effective management.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Chiara Piazzalunga, Linda Greta Dui, Cristiano Termine, Marisa Bortolozzo, Matteo Matteucci, Simona Ferrante
Summary: Dysgraphia is a learning disability characterized by below-average handwriting production. This study examines the role of visual perception in handwriting skills through gamified visual perception tests played with an eye tracker. Machine learning models using game performance, eye-tracking, and drawing data as predictors successfully predicted children at risk of dysgraphia. These results suggest the potential of a new tool for early screening of dysgraphia based on visual perception skills.
Editorial Material
Medicine, General & Internal
Vincenzo Raieli, Vittorio Sciruicchio
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Angelo Torrente, Paolo Alonge, Vincenzo Di Stefano, Roberta Baschi, Raffaele Ornello, Edvige Correnti, Antonino Lupica, Cecilia Camarda, Gabriella Farinella, Vincenzo Raieli, Simona Sacco, Roberto Monastero, Filippo Brighina
Summary: This study describes the characteristics of patients who develop new-onset headache following SARS-CoV-2 infection. The results show that the timing and characteristics of headache vary among patients, and the response to treatment also varies.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Laura Manzo, Federica Reina, Edvige Correnti, Francesca D'Aiuto, Daniela D'Agnano, Andrea Santangelo, Luigi Vetri, Giuseppe Santangelo, Laura Maniscalco, Gabriele Tripi, Vittorio Sciruicchio, Vincenzo Raieli
Summary: This study investigated the clinical course and prognostic factors of pediatric migraine. The study found that familial neurological comorbidity and sleep disorders were unfavorable factors for predicting the long-term prognosis of pediatric migraine. However, patients with severe migraine pain admitted to the emergency department had a similar prognosis to those in outpatient samples.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Daniela D'Agnano, Salvatore Lo Cascio, Edvige Correnti, Vincenzo Raieli, Vittorio Sciruicchio
Summary: Since the first descriptions of visual hallucinations in migraine and occipital lobe epilepsy, recognizing epileptic seizures of the occipital lobe has become a challenge due to the similarities with migraine symptoms. Detailed clinical examination of visual impairment can help differentiate the two diseases, especially in children where overlaps are common. Understanding the distinctive features of visual aura in migraine and visual hallucinations in occipital epilepsy can provide insights into the underlying mechanisms of these conditions.
Article
Biology
Edvige Correnti, Salvatore Lo Cascio, Federica Cernigliaro, Roberta Rossi, Daniela D'Agnano, Giulia Grasso, Annamaria Pellegrino, Barbara Lauria, Andrea Santangelo, Giuseppe Santangelo, Gabriele Tripi, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli
Summary: Non-dental orofacial pain in pediatric patients is uncommon but can have a significant impact on the psychophysical well-being if left unrecognized and untreated. Early identification and treatment of these pain conditions are crucial to prevent negative outcomes in adulthood.
Article
Psychology, Clinical
Alessia Raffagnato, Marina Miscioscia, Rachele Fasolato, Sara Iannattone, Perla Valentini, Eleonora Sale, Michela Gatta
Summary: Non-suicidal self-injury (NSSI) is a growing problem among adolescent groups, both clinical and nonclinical, and is associated with various psychopathological symptoms. However, differences between clinical and nonclinical self-harmers in symptom dimensions, alexithymia, and self-harm-related variables have been understudied. This study investigated these differences by comparing an Italian sample of 63 self-harmers receiving mental health services (clinical group), 44 self-harmers not receiving mental health services (subclinical group), and 231 individuals without a history of NSSI (control group). Questionnaires were used to assess psychopathological symptoms, alexithymia, and NSSI-related variables. The results showed that the clinical and subclinical groups had more severe symptoms and alexithymic traits compared to the control group, with the clinical group showing higher NSSI frequency, disclosure, self-punishment as motive, and suicidal ideation compared to the subclinical group. These findings have implications for clinical practice and prevention efforts among adolescents.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)
Article
Pediatrics
Sara Isoldi, Giovanni Di Nardo, Saverio Mallardo, Pasquale Parisi, Umberto Raucci, Renato Tambucci, Paolo Quitadamo, Silvia Salvatore, Enrico Felici, Fabio Cisaro, Licia Pensabene, Claudia Banzato, Caterina Strisciuglio, Claudio Romano, Patrizia Fusco, Francesca Rigotti, Naire Sansotta, Silvia Caimmi, Salvatore Savasta, Giovanna Zuin, Marina Di Stefano, Silvia Provera, Angelo Campanozzi, Paolo Rossi, Simona Gatti, Mara Corpino, Patrizia Alvisi, Stefano Martelossi, Agnese Suppiej, Paolo Gandullia, Alberto Verrotti, Gianluca Terrin, Caterina Pacenza, Fabiola Fornaroli, Donatella Comito, Stefano D'Arrigo, Pasquale Striano, Federico Raviglione, Marco Carotenuto, Alessandro Orsini, Vincenzo Belcastro, Giovanna Di Corcia, Vincenzo Raieli, Michela Ada Noris Ferilli, Claudia Ruscitto, Elisabetta Spadoni, Salvatore Grosso, Renato D'Alonzo, Amanda Papa, Piero Pavone, Mariaclaudia Meli, Mario Velardita, Martina Mainetti, Nicola Vanacore, Osvaldo Borrelli
Summary: A multicenter web-based survey was conducted among members of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP) to evaluate the diagnostic and therapeutic approaches to CVS in Italy. The survey revealed poor consensus among clinicians in the diagnosis and management of children with CVS, emphasizing the need for a national consensus guideline to standardize practice.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
