Journal
CEPHALALGIA
Volume 32, Issue 8, Pages 607-620Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102412445622
Keywords
Headache; pain; fMRI; functional connectivity; morphometry; somatosensory cortex; insula; cingulate cortex; temporal pole
Categories
Funding
- NIH [K24 NS064050, R01 NS056195, R01-NS073997]
- Merck and Co.
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Aim: Various animal and human studies have contributed to the idea of cortical structural-functional alterations in migraine. Defining concurrent cortical alterations may provide specific insights into the unfolding adaptive or maladaptive changes taking place in cortex in migraine. Methods: From a group of 60 episodic migraineurs, 20 were recruited to the study. Using high-resolution magnetic resonance imaging, structural and functional cortical measures were compared in migraineurs who experienced increased frequency of attacks (HF; 8-14 days/month; n=10), to those who experienced less frequent migraine attacks (LF;<2 days/month; n=10), and to healthy controls (HC; n=20). Results: Parallel structural and functional differences were found as follows: (i) HF patients showed higher thickness in the area representing the face in the post-central gyrus, which correlated with the observed stronger functional activation, suggesting adaptation to repeated sensory drive; (ii) smaller cortical volume was observed in the cingulate cortex that correlated with lower activation in the HF group; and (iii) similarly significant structural and functional differences (HF>LF) were observed in the insula that may reflect potential alteration in affective processing. Conclusion: These results suggest differential response patterns in the sensory vs. affective processing regions in the brain that may be an adaptive response to repeated migraine attacks.
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