Journal
CEPHALALGIA
Volume 32, Issue 13, Pages 963-971Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102412455708
Keywords
Migraine; body mass index; overweight; obesity; prospective study
Categories
Funding
- National Heart, Lung, and Blood Institute [HL-043851, HL-080467]
- National Cancer Institute [CA-47988]
- American Association of University Women
- German Research Foundation (DFG)
- National Institutes of Health
- Dow Corning Corporation
- Bayer Health Care
- Natural Source Vitamin E Association
- California Strawberry Commission
- Tomato Products Wellness Council
- Cambridge Theranostics, Ltd.
- French National Research Agency
- US National Institutes of Health
- Merck
- Migraine Research Foundation
- Parkinson's Disease Foundation
Ask authors/readers for more resources
Background: Some cross-sectional studies have suggested an association between migraine and increased body weight. However, prospective data on the association are lacking. Methods: We conducted a prospective cohort study among 19,162 participants in the Women's Health Study who had a body mass index (BMI) of 18.5- <25 kg/m(2) at baseline. Migraine was self-reported by standardized questionnaires. Main outcome measures were incident overweight (BMI >= 25 kg/m(2)), incident obesity (BMI >= 30 kg/m(2)) and mean weight change. Age- and multivariable-adjusted hazard ratios (HRs) were calculated for the association between migraine and incident overweight and obesity. Differences in weight change were evaluated by analysis of covariance (ANCOVA). Results: A total of 3,483 (18.2%) women reported any migraine history. After 12.9 years of follow-up, 7916 incident overweight and 730 incident obesity cases occurred. Migraineurs had multivariable-adjusted HRs (95% confidence interval) of 1.11 (1.05-1.17) for becoming overweight and 1.00 (0.83-1.19) for becoming obese. These associations remained stable after censoring for chronic diseases and were similar according to migraine aura status. Multivariable-adjusted mean weight change from baseline to the end of study was +4.7 kg for migraineurs and +4.4 kg for women without migraine (p = 0.02). Conclusion: Results of this large prospective study of middle-aged women do not indicate a consistent association between migraine and incident overweight, obesity or relevant weight gain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available