Article
Health Care Sciences & Services
Rebeca Monica Ramirez-Armas, Idalia Garza-Veloz, Juan Carlos Olivas-Chavez, Rosa Martha Covarrubias-Carrillo, Maria Calixta Martinez-Vazquez, Joel Monarrez-Espino, Anayantzin E. Ayala-Haro, Claudia Vanessa Serrano-Amaya, Ivan Delgado-Enciso, Iram Pablo Rodriguez-Sanchez, Margarita L. Martinez-Fierro
Summary: This study examined the association between the 5-HTTLPR gene variant and the occurrence of pre-eclampsia. The results showed that the S/S genotype reduced the probability of developing pre-eclampsia and pre-eclampsia with severity criteria. This suggests that the 5-HTTLPR gene variant of the SLC6A4 gene modifies the risk of pre-eclampsia development.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Eric M. Schoenfeld, Nishant K. Gupta, Shariful A. Syed, Anna Rozenboym, Sasha L. Fulton, Andrea P. Jackowski, Tarique D. Perera, Jeremy D. Coplan
Summary: The study suggests that bonnet macaques reared under stress, carrying the ?s?-allele and having smaller adolescent hippocampal volume, exhibit reduced neurogenesis in adulthood. The positive impact of ipsilateral hippocampal volume on neurogenesis levels was observed.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Kuniyuki Nishina, Qiulu Shou, Hidehiko Takahashi, Masamichi Sakagami, Miho Inoue-Murayama, Haruto Takagishi
Summary: The Ultimatum Game has been used to measure behavioral responses to unfair distribution. Recent studies have focused on the role of the serotonin transporter gene in these responses, but most of these studies have been conducted on non-Asians without confirming whether similar results can be seen in other ethnic groups. It has also been found that behavioral responses to unfair distribution are not limited to victims themselves but also extend to third parties. This study aimed to replicate previous findings in an Asian population and explore the relationship between the serotonin transporter gene and third-party behavior towards unfair distribution.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Linda Garvert, Kevin Kirchner, Hans J. Grabe, Sandra Van der Auwera
Summary: Recent GWAS have found many single nucleotide polymorphisms that affect depressive disorders, suggesting that depression is a heterogeneous disorder influenced by numerous genetic variants with small effect sizes. However, there is limited understanding of the interaction between different genetic risk factors. This study used a genome-wide gene-gene interaction approach and identified a significant interaction effect between the DPF1 gene and the 5-HTTLPR gene on lifetime depression. DPF1, previously not associated with depressive disorders, is expressed exclusively in the brain and plays a major role in neuronal development and neuroplasticity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Cell Biology
Hsin-Yu Liu, Li-Ning Peng, Wei-Ju Lee, Ming-Yueh Chou, Chih-Kuang Liang, Fei-Yuan Hsiao, Ming-Hsien Lin, Liang-Kung Chen
Summary: The study revealed a significant association between Social Vulnerability Index (SVI) and all-cause mortality, with the impact of SVI being more pronounced in non-ApoE gene e4 carriers.
Article
Clinical Neurology
Miriam A. Schiele, Andreas Reif, Jiaxi Lin, Georg W. Alpers, Evelyn Andersson, Gerhard Andersson, Volker Arolt, Jan Bergstrom, Per Carlbring, Thalia C. Eley, Gabriel Esquivel, Tomas Furmark, Alexander L. Gerlach, Alfons Hamm, Sylvia Helbig-Lang, Jennifer L. Hudson, Thomas Lang, Kathryn J. Lester, Nils Lindefors, Tina B. Lonsdorf, Paul Pauli, Jan Richter, Winfried Rief, Susanna Roberts, Christian Rueck, Koen R. J. Schruers, Christiane Thiel, Hans-Ulrich Wittchen, Katharina Domschke, Heike Weber, Ulrike Lueken
Summary: A meta-analysis was conducted on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in moderating the outcome of cognitive behavioral therapy (CBT) in anxiety disorders. Results showed no significant effects of 5-HTTLPR genotype on treatment outcomes at post-treatment and follow-up, indicating that this gene may not be a moderator for CBT outcomes in anxiety disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Pengfei Cheng, Junxiang Zhang, Yu Wu, Wenting Liu, Jiaying Zhu, Ze Chen, Jiarui Zhang, Songwen Guan, Yiming Sun, Jingxia Wang
Summary: This meta-analysis study indicates that the 5-HTTLPR genotype (S/S-Allele) is associated with an increased risk of depression in PD, especially in the recessive model, showing significant correlations in both Caucasian and non-Caucasian subgroups. Therefore, effective measures should be taken to prevent the onset of depression in PD before it occurs.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Medicine, General & Internal
Li Han, Zhenghe Yu, Hongjing Mao
Summary: The study aimed to investigate the association between the genotype of 5-HTTLPR and migraine combined with depression. No significant difference was found in 5-HTTLPR genotype and allele frequency between patients with migraine and depressive disorder and patients with simple migraine, indicating that 5-HTTLPR genotype may not play a role in the onset of migraine combined with depression.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
YingYing Zhang, Shuxia Yao, Helena Schmitt, Benjamin Becker, Keith M. Kendrick, Christian Montag
Summary: The study found that individuals carrying low expressing alleles (S, L-G) are more likely to exhibit higher autistic traits in both Chinese and German samples. Analysis of the positive correlation between autistic traits and IUD tendencies showed that this association is more pronounced in the German sample and can vary depending on 5-HTTLPR/rs25531 genotypes and cultural differences.
BRAIN AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Massimo Santoro, Mariacristina Siotto, Marco Germanotta, Alessia Mastrorosa, Dionysia Papadopoulou, Irene Aprile
Summary: The study investigated the methylation profile of SLC6A4 in 50 patients with subacute stroke and concluded that 5-HTTLPR polymorphisms and SLC6A4 promoter methylation could serve as potential biological markers for recovery in stroke patients undergoing rehabilitation. Significant changes in methylation levels were observed in specific CpG sites after rehabilitation, with a significant relationship found between LL, LS, and SS alleles and the outcome of rehabilitation interventions. Patients with LL and SS genotypes showed significant differences in favorable outcomes after rehabilitation.
Article
Neurosciences
Farzaneh Zareei, Toomas Veidebaum, Jaanus Harro
Summary: The interaction between family relationships and alcohol consumption in young people is related to the serotonin transporter gene promoter region (5-HTTLPR) genotype, with family warmth having a negative correlation and maltreatment having a positive correlation. This association is strongest at age 15 and becomes weaker and statistically insignificant at age 18.
NEUROPSYCHOBIOLOGY
(2022)
Article
Neurosciences
Linlin Liu, Yi Hu, Yumei Lu, Liping Hu, Changqing Gao, Shengjie Nie
Summary: Epigenetic alterations of the SLC6A4 gene are related to the pathophysiology of schizophrenia, with higher methylation levels observed especially in male patients.
NEUROSCIENCE LETTERS
(2022)
Article
Endocrinology & Metabolism
Martin Stoffel, Stefanie Rahn, Andreas B. Neubauer, Markus Moessner, Corina Aguilar -Raab, Beate Ditzen
Summary: This study found that levels of DNA methylation (DNAm) of the serotonin transporter gene (SLC6A4) were associated with dysregulation of the sympatho-adrenal medullary (SAM) and hypothalamic-pituitary-adrenal (HPA) axis. In healthy individuals, higher levels of SLC6A4 DNAm were associated with higher levels of alpha-amylase (sAA), but not with cortisol (sCort) levels. Furthermore, within-person analysis showed that higher levels of SLC6A4 DNAm were associated with lower levels of both sAA and sCort. These results provide insight into the role of SLC6A4 DNAm in the association between environmental stress and stress axes regulation.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhiming Wang, Liping Wu, Peiwen Dong, Qiong Wang, Xiaobin Sun, Lei Liu, Yuanbiao Guo, Yueshan Sun, Tao Shu
Summary: This meta-analysis examined the association between the 5-HTTLPR polymorphism and functional dyspepsia (FD). The overall analysis showed no significant association between the 5-HTTLPR polymorphism and FD, but subgroup analysis revealed a significant association with the EPS subtype of FD, while no association was observed with the PDS subtype.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Jessica L. Rohmann, Maximilian Wechsung, Giancarlo Logroscino, Tobias Kurth
Summary: This article discusses the impact of age and education correction on discrimination performance in cognitive screening tests and quantifies it using a causal framework. The results show that correcting test scores removes meaningful information, leading to a decrease in discrimination performance.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Hebun Erdur, Joachim E. Weber, Anselm Angermaier, Stephan Kinze, Ali Sotoodeh, Claudia Gorski, Kerstin Bollweg, Stefanie Ernst, Farid Kandil, Janina Behrens, Ramanan Ganeshan, Anne Keysers, Malgorzata Kotlarz-Boettcher, Daniel Peters, Ludwig Schlemm, Kirsten Stangenberg-Gliss, Carl Witt, Beata Hennig, Katrin C. Reber, Udo Schneider, Christiana Franke, Ingo Schmehl, Hans-Beatus Straub, Agnes Floeel, Sarah Theen, Matthias Endres, Tobias Kurth, Heinrich J. Audebert
Summary: Implementing a multicomponent system-of-care can reduce the risk of poor outcomes in stroke patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Sofia Oliveira Goncalves, Jessica L. Rohmann, Marco Piccininni, Tobias Kurth, Martin Ebinger, Matthias Endres, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Reinhard Busse, Heinrich J. Audebert
Summary: The study assessed the cost-utility and cost-effectiveness of additional mobile stroke unit (MSU) dispatch in ischemic stroke patients eligible for recanalizing treatments. Results showed that MSU dispatch increased costs but also improved quality-adjusted life years (QALYs), and it was considered cost-effective according to internationally accepted thresholds.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tobias Kurth, Jessica L. Rohmann
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, JoAnn E. Manson, Howard D. Sesso, Tobias Kurth
Summary: There is no significant association between a history of migraine in older women and an increased risk of COVID-19.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Ana S. Oliveira Goncalves, Imke Mayer, Ricarda S. Schulz, Agnes Floeel, Felix von Podewils, Anselm Angermaier, Kerstin Wainwright, Tobias Kurth, NeTKoH Consortium
Summary: Tele-neurology has the potential to improve access to healthcare services and quality of care in rural and underserved areas. The NeTKoH trial aims to evaluate the cost-effectiveness and policy implications of a tele-neurological intervention in primary care in Germany. The economic evaluation will provide high-quality evidence for the effectiveness and potential application of tele-neurological programs.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Kerstin Wainwright, Imke S. Mayer, Ana S. Oliveira S. Goncalves, Ricarda Schulz, Simone Kiel, Jean-Francois Chenot, Agnes Floeel, Felix von Podewils, Anselm Angermaier, Tobias Kurth, NeTKoH Consortium
Summary: This study aims to evaluate the effects of a tele-neurologic intervention in primary care in a rural area in Germany. It uses a cluster-randomized controlled trial design and involves 33 outpatient general practitioner's offices. The intervention group receives tele-neurologic consultations while the control group receives usual care. The study is rated with an importance score of 8.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Jana Fehr, Marco Piccininni, Tobias Kurth, Stefan Konigorski
Summary: This study investigates the transportability of prediction models for cognitive impairment in different external settings. The results suggest that models predicting with causes of the outcome are more transportable than those predicting with consequences. Calibration performance is crucial when assessing model transportability to external settings.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Tobias Kurth, Heinrich J. Audebert, Jessica L. Rohmann
Summary: The B_PROUD study aimed to evaluate the impact of mobile stroke unit (MSU) dispatch on ischemic stroke and transient ischemic attack (TIA) patients. However, a large proportion of patients did not receive MSU care despite being dispatched. The study found that receiving additional MSU care was associated with better functional outcomes compared to conventional care.
Article
Cardiac & Cardiovascular Systems
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, Tobias Kurth
Summary: Adding information on migraine with aura (MA) to cardiovascular disease (CVD) risk prediction models can improve risk prediction accuracy, but does not significantly improve risk stratification among women.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Kurth, Pamela M. Rist
Summary: The connection between migraine and cardiovascular disease is intricate and involves overlapping mechanisms like endovascular disturbances. Challenges in measuring migraine, differentiating causation from prediction, and understanding clinical implications emphasize the importance of further research to guide treatment and cardiovascular risk assessment for migraine sufferers.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)
