Journal
CEPHALALGIA
Volume 30, Issue 11, Pages 1375-1382Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102410368443
Keywords
Migraine; association; BDNF; CGRP; pathophysiology
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [POCTI-034390/99/FCT]
- Sociedade Portuguesa de Cefaleias (SPC)
- National Headache Foundation (NHF) (USA)
- FCT [SFRH/BD/17761/2004]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/17761/2004] Funding Source: FCT
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Objectives: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. Methods: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP-rs1553005-of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis. Results: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio = 1.88, 95% confidence interval: 1.20-2.93) for migraineurs. Conclusion: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored.
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