Journal
CEPHALALGIA
Volume 30, Issue 9, Pages 1073-1081Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102410363492
Keywords
Migraine; major depressive disorder; comorbidity; epidemiology
Categories
Funding
- Spinozapremie [NWO/SPI 56-464-14192]
- Center for Medical Systems Biology (NWO Genomics)
- Twin-Family Database for Behavior Genetics and Genomics Studies (NWO) [480-04-004]
- Borderline Personality Disorder Research Foundation
- Netherlands Organization for Health Research and Development (ZonMw) [10-000-1002]
- Virije University Medical Center
- GGZ inGeest
- Arkin
- Leiden University Medical Center
- GGZ Rivierduinen
- University Medical Center Groningen
- Lentis
- GGZ Friesland
- GGZ Drenthe
- Scientific Institute for Quality of Health Care [IQ Healthcare]
- Netherlands Institute for Health Services Research [NIVEL]
- Netherlands Institute of Mental Health and Addiction [Trimbos])
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Introduction and objective: Migraine and major depressive disorder (MDD) frequently co-occur, but it is unclear whether depression is associated with a specific subtype of migraine. The objective of this study was to investigate whether migraine is qualitatively different in MDD patients (N = 1816) and non-depressed controls (N = 3428). Methods: Migraine symptom data were analyzed using multi-group Latent Class Analysis, and a qualitative comparison was made between the symptom profiles of MDD patients and controls, while allowing for differences in migraine prevalence and severity between groups. Results: In both groups, three migrainous headache classes were identified, which differed primarily in terms of severity. Both mild and severe migrainous headaches were two to three times more prevalent in MDD patients. Migraine symptom profiles showed only minor qualitative differences in the MDD and non-MDD groups: in the severe migrainous headache class, significant differences were observed only in the prevalence of aggravation by physical activity (83% and 91% for the non-MDD and MDD groups, respectively) and aura (42% vs. 53%, respectively). Conclusion: The similar overall symptom profiles observed in the MDD and non-MDD subjects suggest that a similar disease process may underlie migraine in both groups.
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