Article
Multidisciplinary Sciences
Anna Katarzyna Cyganska, Pawel Tomaszewski, Anna Cabak
Summary: This study aimed to determine the pain threshold of selected superficial muscles of the back, taking into account trigger point activity, in young and healthy males and females. The results showed that women had a greater number of active trigger points and lower pain thresholds compared to men. The study also found that a sample size of 30 people was sufficient to detect variations in the pain threshold at trigger points.
Article
Clinical Neurology
Jan Petter Neverdahl, Martin Uglem, Dagfinn Matre, Johannes Orvin Hansen, Morten Engstrom, Erling Tronvik, Lars Jacob Stovner, Trond Sand, Petter Moe Omland
Summary: This study did not provide strong evidence for an increased effect of sleep restriction on pain sensitivity in migraineurs compared to healthy controls, but there might be a slightly increased effect in certain migraine subgroups.
Article
Medicine, General & Internal
Cristina Garcia-Iglesias, Francesca Puledda, Ana Echavarria-Iniguez, Yesica Gonzalez-Osorio, Alvaro Sierra-Mencia, Andrea Recio-Garcia, Ana Gonzalez-Celestino, Gonzalo Valle-Penacoba, Pablo Irimia, Angel Luis Guerrero-Peral, David Garcia-Azorin
Summary: Nummular headache (NH) is a primary headache characterized by coin-shaped pain. The NUMITOR study evaluated the response rate of preventive drugs in NH patients. OnabotulinumtoxinA was the most effective and best-tolerated drug for treating NH, followed by gabapentin.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Patricia Martinez-Merinero, Fernando Aneiros Tarancon, Javier Montanez-Aguilera, Susana Nunez-Nagy, Daniel Pecos-Martin, Ruben Fernandez-Matias, Alexander Achalandabaso-Ochoa, Samuel Fernandez-Carnero, Tomas Gallego-Izquierdo
Summary: The study found a positive relationship between pressure pain threshold (PPT) at C2 and cranio-cervical angle (CCA) in subjects with cervicogenic headache (CGH), moderated by pain intensity. However, there was no significant relationship observed between PPT measured at the muscles and median nerve with CCA. Additionally, the effect of pain intensity on C2 PPT and CCA relationship was significant, while disability did not have a moderating effect.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yan Tereshko, Simone Dal Bello, Christian Lettieri, Enrico Belgrado, Giovanni Merlino, Gian Luigi Gigli, Mariarosaria Valente
Summary: A 58-year-old female patient with nummular headache was successfully treated with a 6-month ketogenic diet and botulinum toxin type A injections. The ketogenic diet could be an effective alternative/complementary therapy for nummular headache patients, although further studies are needed to confirm these results.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Santiago Navarro-Ledesma, Ana Gonzalez-Munoz, James Carroll, Patricia Burton
Summary: This study aims to investigate the impact of whole-body photobiomodulation on pain perception, functionality, quality of soft tissue, central sensitisation, and psychological factors in patients suffering from fibromyalgia syndrome. The study will use a randomised, placebo-controlled clinical trial design to analyze the efficacy and long-term effects of whole-body PBM therapy.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Rehabilitation
Leonardo Intelangelo, Diego Bordachar, Cristian Mendoza, Ignacio Lassaga, Alexandre Carvalho Barbosa, Jose Biurrun Manresa, Christian Mista
Summary: The study aimed to assess generalized hypersensitivity in chronic unilateral shoulder pain, finding significant differences between the symptomatic and asymptomatic sides, but no differences between USP patients and healthy volunteers. The results suggest that USP does not induce generalized hypersensitivity.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2022)
Review
Medicine, General & Internal
Yohwan Kim, Kyuseok Kim
Summary: This study aimed to determine a pressure algometry measurement during abdominal examination that reflects clinical settings of traditional Korean medicine. Through reviewing previous studies and conducting keyword searches, a set of standardized pressure algometry indices, postures, and method sequences were proposed for abdominal examination to make objective assessments in clinical settings.
Review
Anesthesiology
Alexandre Mauricio Passos Nunes, Joao Paulo Azinheira Martins Moita, Maria Margarida Marques Rebelo Espanha, Kristian Kjaer Petersen, Lars Arendt-Nielsen
Summary: The meta-analysis revealed that all PPT measurements were not significantly reduced in office workers with chronic neck pain compared with healthy workers. There were no correlations found between the upper trapezius PPT and pain intensity and disability. Further studies are needed to quantify the differences in PPTs.
Article
Rehabilitation
Kamiar Ghoseiri, Mohammad Yusuf Rastkhadiv, Mostafa Allami, Phillip Page, Lars L. Andersen, Duane C. Button
Summary: This study aimed to investigate pain sensitivity and its association with prosthesis use in veterans with transtibial amputation. The findings showed significant differences in pain sensitivity among different anatomical locations and participants, and longer prosthesis use was associated with increased pain sensitivity.
ASSISTIVE TECHNOLOGY
(2023)
Article
Orthopedics
E. P. Rampazo, V. R. da Silva, A. L. M. de Andrade, C. G. N. Back, P. M. Madeleine, L. Arendt-Nielsen, Richard Eloin Liebano
Summary: This study reveals significant differences in central sensitization, psychosocial factors, and range of motion between individuals with chronic neck pain and healthy controls. It also shows a correlation between pain intensity, neck disability, and psychosocial factors in people with chronic neck pain.
Article
Health Care Sciences & Services
Andreas Konrad, Kazuki Kasahara, Riku Yoshida, Yuta Murakami, Ryoma Koizumi, Masatoshi Nakamura
Summary: This study aimed to investigate the repeated application of PPT tests in different muscles. The results showed a significant increase in PPT in the elbow flexors and knee extensors, starting from the eighth and ninth assessments, respectively. However, there was no significant change in the ankle plantar flexor muscles. Based on these findings, it is recommended to perform between two and seven PPT assessments to avoid overestimation.
Article
Biochemistry & Molecular Biology
Edurne Ubeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia Maria Gallego-Sendarrubias, Cesar Fernandez-de-Las-Penas, Jose Luis Arias-Buria, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study found a good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of the condition and hence provide synergistic information.
Article
Integrative & Complementary Medicine
Mustafa Corum, Tugba Aydin, Cansin Medin Ceylan, Fatma Nur Kesiktas
Summary: The study evaluated the effects of two manual treatment methods in tension-type headache patients with neck pain and found that manipulation combined with exercise was superior to myofascial release in terms of reducing headache frequency, severity, and PPT scores. The manipulation group also showed significant improvements in all outcome criteria compared to the control group, suggesting that manipulation and exercise could be a promising approach for TTH patients with cervical dysfunction.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Anesthesiology
Cristina Garcia-Iglesias, Cristina Martinez-Badillo, David Garcia-Azorin, Javier Trigo-Lopez, Enrique Martinez-Pias, Angel Luis Guerrero-Peral
Summary: This study retrospectively analyzed 274 patients with localized round headache, of which 8 were considered secondary cases. The phenotype of secondary NH overlaps with primary NH, and treatment often does not require removal of underlying lesions, with many cases responding positively to prophylactic treatment.
Letter
Psychology, Clinical
Cesar Fernandez-de-las-Penas, Jose D. Martin-Guerrero, Ignacio Cancela-Cilleruelo, Paloma Moro-Lopez-Menchero, Jorge Rodriguez-Jimenez, Oscar J. Pellicer-Valero
PSYCHOLOGICAL MEDICINE
(2023)
Article
Infectious Diseases
Cesar Fernandez-de-las-Penas, Jose D. Martin-Guerrero, Lidiane L. Florencio, Esperanza Navarro-Pardo, Jorge Rodriguez-Jimenez, Juan Torres-Macho, Oscar J. Pellicer-Valero
Summary: By using cluster analysis on clinical data of COVID-19 survivors, three different subgroups were identified with distinct post-COVID symptoms and clinical characteristics. The study found that some patients experienced more long-term symptoms post-recovery, with greater limitations in daily activities, higher levels of anxiety and depression, and poorer sleep quality.
Article
Clinical Neurology
Yuka Oono, Hidenori Kubo, Saori Takagi, Kelun Wang, Lars Arendt-Nielsen, Hikaru Kohase
Summary: This study examined the interaction between conditioned pain modulation and thermal pain illusions. The results showed that conditioned pain modulation can be induced by alternating painful cold-heat pulse stimulation, and the presence of thermal pain illusions does not influence this modulation.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Cesar Fernandez-de-las-Penas, Ignacio Cancela-Cilleruelo, Paloma Moro-Lopez-Menchero, Jorge Rodriguez-Jimenez, Oscar J. Pellicer-Valero, Jose D. Martin-Guerrero, Lars Arendt-Nielsen
Summary: This multicenter cohort study investigated the prevalence and risk factors of musculoskeletal post-COVID pain. The study found that musculoskeletal pain remains highly prevalent one year after hospitalization, with female sex, previous history of pain symptoms, pain symptoms at onset, and days at hospital being associated factors.
Review
Clinical Neurology
Cesar Fernandez-de-Las-Penas, Maria L. Cuadrado, Victor Gomez-Mayordomo, David Garcia-Azorin, Lars Arendt-Nielsen
Summary: This article analyzes the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants (historical strain, Alpha, Delta, and Omicron) and discusses the different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Review
Medicine, General & Internal
David Fernandez-Hernando, Cesar Fernandez-de-las-Penas, Ana Machado-Martin, Santiago Angulo-Diaz-Parreno, Francisco J. Garcia-Esteo, Juan A. Mesa-Jimenez
Summary: In this study, a systematic review and meta-analysis were conducted to evaluate the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with tinnitus. The results showed that the treatment had a positive effect on related disability in patients with tinnitus, although its clinical relevance was low. More research is needed to draw firm conclusions about the effect of non-invasive neuromodulation of the vagus nerve on tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tamara del Corral, Raul Fabero-Garrido, Gustavo Plaza-Manzano, Cesar Fernandez-de-las-Penas, Marcos Jose Navarro-Santana, Ibai Lopez-de-Uralde-Villanueva
Summary: The study aimed to establish the minimal clinically important difference (MCID) for inspiratory muscle strength (MIP) and endurance (IME) in individuals with long-term post-COVID-19 symptoms. Results showed that a change of at least 18 cmH(2)O and 22.1% of that predicted for MIP, and 328.5s for IME represented the MCID. All variables showed acceptable discrimination, with MIP being the variable with the best discriminative ability when expressed as a percentage of prediction. Participants classified as improved had significantly greater improvements in quality of life and lung function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Cesar Fernandez-de-las-Penas, Jo Nijs, Barbara Cagnie, Robert D. Gerwin, Gustavo Plaza-Manzano, Juan A. Valera-Calero, Lars Arendt-Nielsen
Summary: Myofascial pain syndrome involves the presence of myofascial trigger points (TrPs), which can cause referred pain. The classification of TrPs as primary or secondary phenomena and their relationship to central or peripheral nervous system disorders is controversial. The International Association for the Study of Pain (IASP) proposed a clinical criteria and grading system in 2021 to classify patients based on nociceptive, neuropathic, or nociplastic pain phenotypes. While myofascial TrP pain is traditionally categorized as nociceptive, evidence suggests it may also be present in patients with predominantly nociplastic pain. Successful clinical treatment outcomes may be achieved by accurately classifying myofascial TrP pain into these phenotypes.
Article
Biology
Daniel Ulman-Macon, Cesar Fernandez-de-las-Penas, Santiago Angulo-Diaz-Parreno, Jose L. Arias-Buria, Juan A. Mesa-Jimenez
Summary: This study compared the morphology of the suboccipital muscles between women with temporomandibular disorder (TMD) and healthy controls. The results showed that women with myofascial TMD pain had reduced thickness, cross-sectional area, and perimeter in the suboccipital muscles compared to healthy women, while there were no significant differences in width and depth. These morphological changes may be related to muscle atrophy and are similar to those found in women with headaches. Further research is needed to investigate the clinical relevance and potential treatment options for myofascial TMD patients.
Article
Clinical Neurology
Johan Roikjer, Suganthiya Santhiapillai Croosu, Mette Krabsmark Borbjerg, Tine Maria Hansen, Jens Brondum Frokjaer, Lars Arendt-Nielsen, Niels Ejskjaer, Carsten Dahl Morch
Summary: This study aimed to evaluate the diagnostic performance of histamine-induced flare response and optimize the time required for assessment. The results showed that flare area size had better diagnostic performance than mean flare intensity and could distinguish people with and without diabetic peripheral neuropathy after 4 minutes. Flare area size achieved a diagnostic performance comparable to a full examination after 6-7 minutes.
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas, Lars Arendt-Nielsen, Gema Diaz-Gil, Francisco Gomez-Esquer, Antonio Gil-Crujera, Stella M. Gomez-Sanchez, Silvia Ambite-Quesada, Maria A. Palomar-Gallego, Oscar J. Pellicer-Valero, Rocco Giordano
Summary: The study aimed to investigate the association between the Apolipoprotein E (ApoE) gene and long COVID symptoms. The results showed no significant relationship between different genotypes of the ApoE gene (ApoE ε2, ApoE ε3, ApoE ε4) and the presence of long COVID symptoms.
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas, Lidiane L. Florencio, Ana I. de-la-Llave-Rincon, Ricardo Ortega-Santiago, Margarita Cigaran-Mendez, Stella Fuensalida-Novo, Gustavo Plaza-Manzano, Lars Arendt-Nielsen, Juan A. Valera-Calero, Marcos J. Navarro-Santana
Summary: This study synthesized current evidence on prognostic factors for predicting postoperative pain after knee or hip replacement. The findings suggest that various preoperative factors, including race, opioid use, preoperative function, neuropathic pain symptoms, and anxiety, are associated with postoperative chronic pain. Additionally, certain comorbidities, such as heart disease and lung disease, are not associated with postoperative chronic pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rehabilitation
Stefano Di Antonio, Lars Arendt-Nielsen, Matteo Castaldo
Summary: Currently, examination of migraine patients relies on a clinical interview investigating symptoms characteristics. However, to identify distinct migraine subtypes and allow personalized treatment, biomarkers to profile these subtypes should be utilized in clinical and research settings. Therefore, physical and psychophysical examinations aimed at quantitatively assessing migraine features should be included.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2023)
Article
Medicine, General & Internal
Ignacio Cancela-Cilleruelo, Jorge Rodriguez-Jimenez, Cesar Fernandez-de-las-Penas, Joshua A. Cleland, Jose L. Arias-Buria
Summary: The potential role of the radial nerve in lateral epicondylalgia was investigated in this study. The results showed lower pressure pain thresholds and increased cross-sectional area of the radial nerve in individuals with lateral epicondylalgia. Additionally, the cross-sectional area of the radial nerve was negatively correlated with pressure pain thresholds and positively correlated with function. These findings suggest that there is a widespread sensitization of nerve tissues in people with lateral epicondylalgia, and the radial nerve may play a role in altered pain processing in this condition.
