Article
Medicine, General & Internal
Masahito Katsuki, Junko Kawahara, Yasuhiko Matsumori, Chinami Yamagishi, Akihito Koh, Shin Kawamura, Kenta Kashiwagi, Tomohiro Kito, Akio Entani, Toshiko Yamamoto, Miyako Otake, Takashi Ikeda, Fuminori Yamagishi
Summary: Based on a questionnaire-based survey, this study aimed to investigate the prevalence and characteristics of headache disorders, including migraine, CDH, and MOH, among the elderly in Japan. The results showed a relatively high prevalence of headache disorders in this population, with different characteristics identified in different clusters. Severe headaches accompanied by comorbidities appeared to be unique to the elderly.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Karthik Nagaraj, Diana Y. Wei, Francesca Puledda, Hsing-Yu Weng, Sadaf Waheed, Nicolas Vandenbussche, Jonathan J. Y. Ong, Peter J. Goadsby
Summary: This study compared the clinical phenotype of chronic migraine (CM) patients to patients with the chronic migraine subtype of new daily persistent headache (NDPH-CM). The UK cohort showed that CM patients had an earlier age of first headache onset, more associated migrainous symptoms, and a higher prevalence of a family history of headache compared to NDPH-CM patients. No differences were found in the US cohort. Osmophobia and older age at presentation were negative predictors of NDPH-CM.
Article
Clinical Neurology
Todd J. Schwedt, Joseph G. Hentz, Soma Sahai-Srivastava, Nicole M. Spare, Vincent T. Martin, Christina Treppendahl, Kathleen Digre, Nathan L. Bennett, Marius Birlea, David Watson, Natalia Murinova, Teri Robert, David W. Dodick
Summary: The study described headache characteristics, medication use, disability, and quality of life in patients with chronic migraine (CM) and medication overuse headache (MOH) from the United States. Findings showed a significant burden on patients with CM and MOH, with higher headache frequency associated with greater impact on functioning, pain interference, and quality of life.
Article
Clinical Neurology
Yen-Feng Wang, Chia-Chun Yu, Ai Seon Kuan, Shih-Pin Chen, Shuu-Jiun Wang
Summary: The study found that in chronic migraine patients, comorbid medication-overuse headache (MOH) is associated with an increased risk of suicidal ideation and prior suicide attempt.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Niushen Zhang, Yohannes W. Woldeamanuel
Summary: The study revealed a significant association between cannabis use and an increased prevalence of medication overuse headache in patients with chronic migraine. A bidirectional association between cannabis and opioid use was also observed.
Article
Clinical Neurology
Abouch V. V. Krymchantowski, Carla Jevoux, Ana Gabriela Krymchantowski, Raimundo Pereira Silva-Neto
Summary: Anti-CGRP monoclonal antibodies added to conventional treatments can effectively reduce the frequency of headaches and the use of symptomatic medications for patients with chronic migraine and medication overuse headache.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michael J. Marmura, Hans-Christoph Diener, Robert P. Cowan, Stewart J. Tepper, Merle L. Diamond, Amaal J. Starling, Joe Hirman, Lahar Mehta, Thomas Brevig, Roger Cady
Summary: In patients with chronic migraine and medication-overuse headache treated with eptinezumab in the PROMISE-2 study, there was a significant reduction in the use of acute headache medication and a substantial proportion of patients did not meet diagnostic thresholds for either CM or MOH throughout the entire treatment period.
Article
Clinical Neurology
Hong-Kyun Park, Min Kyung Chu, Sun-Young Oh, Heui-Soo Moon, Tae-Jin Song, Mi Ji Lee, Jin-Ju Kang, Yooha Hong, Soo-Jin Cho
Summary: This study enrolled 229 patients with medication overuse headache in Korea, revealing that patients commonly experienced chronic headaches and medication overuse, severely impacting daily functioning. A significant proportion of patients exhibited moderate to severe depression and anxiety, while the use of preventive treatments increased during the study period.
Article
Biology
Jacob Genizi, Morya Shnaider, Liat Yaniv, Nogah C. Kerem, Keren Nathan, Irina Chistyakov
Summary: Medication overuse headaches are common in children with chronic headaches, particularly those with tension-type headaches (TTH). They appear to be more pronounced in TTH patients compared to migraine sufferers, and have a higher prevalence among females.
Article
Behavioral Sciences
Simona Guerzoni, Carlo Baraldi, Flavia Lo Castro, Maria Michela Cainazzo, Luca Pani
Summary: This study aims to explore the effectiveness and safety of galcanezumab in the treatment of chronic migraine with medication overuse-headache. The results showed that galcanezumab significantly reduced the number of migraine days per month, the frequency and duration of painkiller usage, and improved the impact of headache on patients' daily life. It was also found that patients with higher baseline impairment and more failed preventive treatments may have less benefit from galcanezumab. Overall, galcanezumab is effective and safe for the treatment of chronic migraine with medication overuse-headache.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Marcella Curone, Vincenzo Tullo, Henri Albert Didier, Gennaro Bussone
Summary: Monoclonal antibodies inhibiting CGRP are effective in reducing monthly headache days in migraine patients with medication overuse headache.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
David W. Dodick, Erin G. Doty, Sheena K. Aurora, Dustin D. Ruff, Virginia L. Stauffer, Jakub Jedynak, Yan Dong, Eric M. Pearlman
Summary: The study demonstrates that galcanezumab is effective in preventing episodic and chronic migraine in patients with acute medication overuse, significantly reducing the number of monthly migraine days and medication overuse rates compared to placebo.
Article
Medicine, General & Internal
Yen-Feng Wang, Yi-Shiang Tzeng, Chia-Chun Yu, Yu-Hsiang Ling, Shih-Pin Chen, Kuan-Lin Lai, Shuu-Jiun Wang
Summary: Dependence behaviors were characterized in patients with medication-overuse headache (MOH) using the Leeds dependence questionnaire (LDQ), and the clinical utility of LDQ in the diagnosis of MOH was determined. The results showed a positive correlation between LDQ scores and the monthly frequency of acute medication use. MOH patients had higher LDQ scores, and an LDQ score of >= 7 was found to be useful in the detection of MOH.
Article
Clinical Neurology
Masahito Katsuki, Chinami Yamagishi, Yasuhiko Matsumori, Akihito Koh, Shin Kawamura, Kenta Kashiwagi, Tomohiro Kito, Akio Entani, Toshiko Yamamoto, Takashi Ikeda, Fuminori Yamagishi
Summary: This study investigated the prevalence of medication-overuse headache (MOH) in a general Japanese population for the first time. The results showed a prevalence of 2.32% among the surveyed population. MOH was more common among females and middle-aged individuals, with combination analgesics being the most commonly overused medication. Clustering analysis revealed three distinct clusters among the MOH patients, with age and frequency of acute medication use being important factors for grouping.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Todd J. Schwedt, Soma Sahai-Srivastava, Natalia Murinova, Marius Birlea, Zubair Ahmed, Kathleen Digre, Kristina Lopez, William Mullally, Maike Tiede Blaya, Karly Pippitt, Fred Michael Cutrer, Justin DeLange, Howard Schecht, Paul Rizzoli, Judy Lane, John Wald, Melissa M. Cortez, Vincent T. Martin, Nicole M. Spare, Joseph G. Hentz, Teri Robert, David W. Dodick
Summary: Chronic migraine with medication overuse leads to severe negative consequences on an individual's life, with depression symptoms being the strongest predictor of pain interference and headache impact.
Article
Clinical Neurology
Jon H. Eliasson, Ann Scher, Dawn C. Buse, Gretchen Tietjen, Richard B. Lipton, Lenore J. Launer, Unnur A. Valdimarsdottir, Larus S. Gudmundsson
Article
Multidisciplinary Sciences
Rosemay A. Remigio-Baker, Seth Kiser, Hamid Ferdosi, Emma Gregory, Scot Engel, Sean Sebesta, Daniel Beauchamp, Saafan Malik, Ann Scher, Sidney R. Hinds
Article
Clinical Neurology
Ann Scher, James S. McGinley, R. J. Wirth, Richard B. Lipton, Heidi Terrio, Lisa A. Brenner, Wesley R. Cole, Karen Schwab
Summary: The study found that post-traumatic headaches differ from other headaches in terms of symptom complexity, with post-traumatic headache patients more likely to seek medical care for headaches.
Article
Immunology
Nusrat J. Epsi, Stephanie A. Richard, Eric D. Laing, Anthony C. Fries, Eugene Millar, Mark P. Simons, Caroline English, Christopher J. Colombo, Rhonda E. Colombo, David A. Lindholm, Anuradha Ganesan, Ryan C. Maves, Nikhil Huprikar, Derek Larson, Katrin Mende, Sharon W. Chi, Cristian Madar, Tahaniyat Lalani, Christopher C. Broder, David Tribble, Brian K. Agan, Timothy H. Burgess, Simon D. Pollett
Summary: Obesity is strongly correlated with COVID-19 severity in US Military Health System beneficiaries, as obese patients may have higher viral loads and stronger immune responses following SARS-CoV-2 infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Clinical Neurology
Hakan Ashina, Anna K. Eigenbrodt, Tad Seifert, Alexandra J. Sinclair, Ann Scher, Henrik W. Schytz, Mi Ji Lee, Roberto De Icco, Alan G. Finkel, Messoud Ashina
Summary: Post-traumatic headache is a common sequela of traumatic brain injury and significant progress has been made in understanding its clinical features and identifying effective therapies. This disorder is increasingly recognized as heterogeneous, with different subphenotypes potentially responding better to specific therapies. More evidence-based research is needed to address the current shortcomings in diagnostic criteria and treatment selection.
Article
Immunology
Ryan C. Maves, Stephanie A. Richard, David A. Lindholm, Nusrat Epsi, Derek T. Larson, Christian Conlon, Kyle Everson, Steffen Lis, Paul W. Blair, Sharon Chi, Anuradha Ganesan, Simon Pollett, Timothy H. Burgess, Brian K. Agan, Rhonda E. Colombo, Christopher J. Colombo
Summary: The study evaluated the prognostic performance of the National Early Warning Score (NEWS) and an age-based modification (NEWS+age) in COVID-19 patients. Patients with low NEWS scores had shorter hospital stays, lower disease severity, and a negative predictive value of 97.2% for progression to invasive ventilation or death.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Zhongyan Lu, Eric D. Laing, Jarina Pena DaMata, Katherine Pohida, Marana S. Tso, Emily C. Samuels, Nusrat J. Epsi, Batsukh Dorjbal, Camille Lake, Stephanie A. Richard, Ryan C. Maves, David A. Lindholm, Julia S. Rozman, Caroline English, Nikhil Huprikar, Katrin Mende, Rhonda E. Colombo, Christopher J. Colombo, Christopher C. Broder, Anuradha Ganesan, Charlotte A. Lanteri, Brian K. Agan, David Tribble, Mark P. Simons, Clifton L. Dalgard, Paul W. Blair, Josh Chenoweth, Simon D. Pollett, Andrew L. Snow, Timothy H. Burgess, Allison M. W. Malloy
Summary: The study found that SARS-CoV-2-specific antibodies and T cells could still be detected 12 months after infection, with higher frequencies of SARS-CoV-2-specific CD4 T cells and antibodies seen in severe cases at 12 months. Additionally, polyfunctional and cytotoxic T cells responsive to SARS-CoV-2 were identified even in participants with a wide spectrum of disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
F. Julian Lantry, Nusrat J. Epsi, Simon D. Pollett, Mark P. Simons, David A. Lindholm, Rhonda E. Colombo, Anthony C. Fries, Ryan C. Maves, Anuradha Ganesan, Gregory C. Utz, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Christopher J. Colombo, Sharon W. Chi, Cristian Madar, Nikhil Huprikar, Derek T. Larson, Samantha Bazan, Christopher C. Broder, Eric D. Laing, Caroline English, Charlotte Lanteri, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Stephanie A. Richard
Summary: This study compared the detection of SARS-CoV-2 in swab samples collected on the same day and found that nasopharyngeal swabs detected the virus more accurately than other swab types. The sensitivity of non-nasopharyngeal swabs decreased over time.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Stephanie A. Richard, Simon D. Pollett, Charlotte A. Lanteri, Eugene Millar, Anthony C. Fries, Ryan C. Maves, Gregory C. Utz, Tahaniyat Lalani, Alfred Smith, Rupal M. Mody, Anuradha Ganesan, Rhonda E. Colombo, Christopher J. Colombo, David A. Lindholm, Cristian Madar, Sharon Chi, Nikhil Huprikar, Derek T. Larson, Samantha E. Bazan, Caroline English, Edward Parmelee, Katrin Mende, Eric D. Laing, Christopher C. Broder, Paul W. Blair, Josh G. Chenoweth, Mark P. Simons, David R. Tribble, Brian K. Agan, Timothy H. Burgess
Summary: In the first month after COVID-19 infection, older age, being of Asian, Black, or Hispanic race/ethnicity, and obesity are associated with an increased risk of SARS-CoV-2 hospitalization. Some acute cases of SARS-CoV-2 infection require long-term oxygen therapy, and the infection has a significant impact on short-term functional status. A considerable number of MHS beneficiaries had not returned to normal activities by 1 month post-infection.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Stephanie A. Richard, Nusrat J. Epsi, Simon Pollett, David A. Lindholm, Allison M. W. Malloy, Ryan Maves, Gregory C. Utz, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Anuradha Ganesan, Rhonda E. Colombo, Christopher J. Colombo, Sharon W. Chi, Nikhil Huprikar, Derek T. Larson, Samantha Bazan, Cristian Madar, Charlotte Lanteri, Julia S. Rozman, Caroline English, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, John H. Powers
Summary: The FLU-PRO Plus instrument was assessed for its measurement properties in individuals with COVID-19, showing good reliability, construct validity, known-groups validity, and responsiveness to change. The study found moderate to high correlations between FLU-PRO Plus scores and disease severity ratings, indicating its effectiveness in assessing symptoms in SARS-CoV-2 infection.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Nusrat J. Epsi, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Anthony C. Fries, Ryan C. Maves, Rhonda E. Colombo, Derek T. Larson, Alfred Smith, Sharon W. Chi, Carlos J. Maldonado, Evan C. Ewers, Milissa U. Jones, Catherine M. Berjohn, Daniel H. Libraty, Margaret Sanchez Edwards, Caroline English, Julia S. Rozman, Rupal M. Mody, Christopher J. Colombo, Emily C. Samuels, Princess Nwachukwu, Marana S. Tso, Ann Scher, Celia Byrne, Jennifer Rusiecki, Mark P. Simons, David Tribble, Christopher C. Broder, Brian K. Agan, Timothy H. Burgess, Eric D. Laing, Simon D. Pollett
Summary: Prior SARS-CoV-2 infection followed by vaccination, or vice versa, leads to a stronger and more enduring IgG response compared to infection or vaccination alone. The timing between infection and vaccination affects the magnitude of post-vaccine immune response.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Clinical Neurology
Ann I. Scher, Lars Bendtsen
Article
Oncology
Julie A. Bytnar, Jie Lin, Brett J. Theeler, Ann Scher, Craig D. Shriver, Kangmin Zhu
Summary: The study suggests that there is a significant association between psychiatric illnesses and subsequent brain cancer diagnosis, which may not be solely due to detection bias. Psychiatric illnesses might serve as an early manifestation of brain cancer.
CANCER CAUSES & CONTROL
(2022)
Article
Immunology
Stephanie A. Richard, Nusrat J. Epsi, David A. Lindholm, Allison M. W. Malloy, Ryan C. Maves, Catherine M. Berjohn, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Anuradha Ganesan, Nikhil Huprikar, Rhonda E. Colombo, Christopher J. Colombo, Cristian Madar, Milissa U. Jones, Derek T. Larson, Evan C. Ewers, Samantha Bazan, Anthony C. Fries, Carlos J. Maldonado, Mark P. Simons, Julia S. Rozman, Liana Andronescu, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Simon D. Pollett, John H. Powers
Summary: This study found that being fully vaccinated against SARS-CoV-2 is associated with a lower severity of patient-reported symptoms, leading to an earlier return to usual activities. Infection with the Delta variant is associated with higher FLU-PRO Plus scores, even after controlling for vaccination status.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Kjetil Bjornevik, Marianna Cortese, Brian C. Healy, Jens Kuhle, Michael J. Mina, Yumei Leng, Stephen J. Elledge, David W. Niebuhr, Ann Scher, Kassandra L. Munger, Alberto Ascherio
Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.