Article
Clinical Neurology
Xiaoyan Bai, Wei Wang, Xueyan Zhang, Zhangxuan Hu, Xue Zhang, Yingkui Zhang, Hefei Tang, Yaqing Zhang, Xueying Yu, Ziyu Yuan, Peng Zhang, Zhiye Li, Xun Pei, Yonggang Wang, Binbin Sui
Summary: This study investigated the perfusion variances of bilateral amygdala in migraine patients. The results showed increased cerebral blood flow and arterial cerebral blood volume in the left amygdala of chronic migraine patients. The increased perfusion parameters of bilateral amygdala were positively correlated with MIDAS score in chronic migraine patients.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Valentina Rebecchi, Daniela Gallo, Lucia Princiotta Cariddi, Eliana Piantanida, Payam Tabaee Damavandi, Federico Carimati, Marco Gallazzi, Alessandro Clemenzi, Paola Banfi, Elisa Candeloro, Maria Laura Tanda, Marco Mauri, Maurizio Versino
Summary: The study focuses on the relationship between vitamin D levels and pain chronification and extension in headache disorders. Findings suggest that vitamin D deficiency may be related to chronic headache due to its anti-inflammatory and tolerogenic properties, supporting the idea of a neuroinflammatory mechanism underlying migraine chronification.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Sang-Hwa Lee, Yeonkyeong Lee, Minji Song, Jae Jun Lee, Jong-Hee Sohn
Summary: The study found that patients with chronic migraine exhibit frontal lobe dysfunction, particularly in dorsolateral functioning, but the presence or absence of Medication Overuse Headache (MOH) did not affect frontal lobe function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Stewart J. Tepper, Messoud Ashina, Uwe Reuter, Yngve Hallstroem, Gregor Broessner, Jo H. Bonner, Hernan Picard, Sunfa Cheng, Denise E. Chou, Feng Zhang, Jan Klatt, Daniel D. Mikol
Summary: The study found that treatment with erenumab in patients with migraine is associated with a significant and sustained reduction in the use of acute headache medication, particularly migraine-specific medication.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Lars Michels, Nabin Koirala, Sergiu Groppa, Roger Luechinger, Andreas R. Gantenbein, Peter S. Sandor, Spyros Kollias, Franz Riederer, Muthuraman Muthuraman
Summary: Background Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network. Methods 19 healthy controls (HC), 17 EM patients and 12 CM patients were included. Cortical thickness and subcortical volumes were computed, and topology was analyzed using a graph theory analytical framework and network-based statistics. We further used support vector machines regression (SVR) to identify whether these network measures were able to predict clinical parameters. Results Network based statistics revealed significantly lower interregional connectivity strength between anatomical compartments including the fronto-temporal, parietal and visual areas in EM and CM when compared to HC. Higher assortativity was seen in both patients' group, with higher modularity for CM and higher transitivity for EM compared to HC. For subcortical networks, higher assortativity and transitivity were observed for both patients' group with higher modularity for CM. SVR revealed that network measures could robustly predict clinical parameters for migraineurs. Conclusion We found global network disruption for EM and CM indicated by highly segregated network in migraine patients compared to HC. Higher modularity but lower clustering coefficient in CM is suggestive of more segregation in this group compared to EM. The presence of a segregated network could be a sign of maladaptive reorganization of headache related brain circuits, leading to migraine attacks or secondary alterations to pain.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Food Science & Technology
Angelo Torrente, Laura Pilati, Salvatore Di Marco, Simona Maccora, Paolo Alonge, Lavinia Vassallo, Antonino Lupica, Serena Coppola, Cecilia Camarda, Nadia Bolognini, Filippo Brighina
Summary: This study found that multisensory integration is modified in chronic migraine, and onabotulinumtoxinA is effective in preventing chronic migraine and restoring multisensory processing.
Article
Clinical Neurology
Michael Ament, Kathleen Day, Virginia L. Stauffer, Vladimir Skljarevski, Mallikarjuna Rettiganti, Eric Pearlman, Sheena K. Aurora
Summary: Galcanezumab reduces the frequency of migraine headache days and alleviates accompanying symptoms, such as nausea and/or vomiting, photophobia and phonophobia, improving patients' quality of life, especially for those with episodic or chronic migraine.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Gulen Guler Aksu, Ozan Kayar, Ali Evren Tufan, Meryem Ozlem Kutuk, Ayse Nur Ozdag Acarli, Damla Hazal Sucu, Bahar Tasdelen, Fevziye Toros, Aynur Ozge
Summary: This study aimed to investigate early maladaptive schemas (EMSs) in adolescents with episodic migraine (EM) and chronic migraine (CM). The results showed that the CM group had a higher prevalence of defectiveness/shame, mistrust/abuse, abandonment/instability, enmeshment/undeveloped self, self-sacrifice, and subjugation schemas. In terms of schema domains, the CM group scored significantly higher in disconnection/rejection and other orientations. Psychopathology did not affect the EMS scores, but a history of sexual abuse did.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Patricia Pozo-Rosich, Gianluca Coppola, Julio Pascual, Todd J. Schwedt
Summary: Data from various studies have been utilized to develop chronic migraine biomarkers, which may assist with diagnosis, prognosticating patient outcomes, predicting treatment responses, etc. However, further optimization and validation are still needed.
Article
Clinical Neurology
Stephanie J. Nahas, Steffen Naegel, Joshua M. Cohen, Xiaoping Ning, Lindsay Janka, Verena Ramirez Campos, Lynda J. Krasenbaum, Dagny Holle-Lee, David Kudrow, Christian Lampl
Summary: This study evaluated the efficacy, safety, and tolerability of fremanezumab in patients aged >= 60 years with migraine, showing significant reductions in monthly migraine days over 12 weeks and improvements in quality of life, with low rates of adverse events.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Shigekazu Kitamura, Takao Takeshima, Daishi Yui, Gabriel Paiva da Silva Lima, Reija Koukakis, Cheng Peng, Ryuji Yoshida, Yotaro Numachi, Miki Hasebe
Summary: This analysis evaluated the efficacy of erenumab in Japanese patients with different migraine frequencies. The results showed that erenumab significantly improved migraine symptoms.
NEUROLOGY AND THERAPY
(2023)
Review
Clinical Neurology
Stewart J. Tepper, Huma U. Sheikh, Carrie O. Dougherty, Stephanie J. Nahas, Paul K. Winner, Ananda Krishna Karanam, Andrew M. Blumenfeld, Ahmad Abdrabboh, Soeren Rasmussen, Jamie L. Weiss, Jessica Ailani
Summary: This article evaluates the therapeutic and tolerability differences between Erenumab 70 mg and 140 mg based on evidence from published literature. The results indicate that some patients may benefit from a dosage of 140 mg, especially those with difficult-to-treat disease and prior treatment failures. Cumulative data support a therapeutic gain with an increase from Erenumab 70 mg to 140 mg and provide a rationale for initiating 140 mg in selected patients.
Article
Clinical Neurology
Murat Gonen, Sevim Ozdogan, Ferhat Balgetir, Caner Feyzi Demir, Emrah Aytac, Bulent Mungen
Summary: Recent studies have shown that serum NSE and S100B levels are significantly elevated in both episodic and chronic migraine patients, indicating neuronal and glial involvement in the pathophysiology of migraine. Furthermore, the higher levels of these markers in cases of chronic migraine suggest an ongoing pathological process even during the interictal period.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Licia Grazzi, Danilo Antonio Montisano, Alberto Raggi, Paul Rizzoli
Summary: This study suggests that a mindfulness-based intervention delivered via web can be effective in reducing headache frequency, symptoms of depression, and catastrophizing, as well as improving disability in adolescents with chronic migraine and high-frequency episodic migraine. However, no significant change was observed in anxiety level. These findings provide initial support for the use of patient education and mindfulness-based programs in this population.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Piero Barbanti, Peter J. Goadsby, Giorgio Lambru, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul, Bjorn Sperling
Summary: Eptinezumab significantly improves work productivity and daily activity ability in patients with prior preventive treatment failures.
JOURNAL OF HEADACHE AND PAIN
(2022)
