Article
Multidisciplinary Sciences
Leila Fernanda dos Santos, Devisson dos Santos Silva, Micael Deivison de Jesus Alves, Erika Vitoria Moura Pereira, Hortencia Reis do Nascimento, Matheus Santos de Sousa Fernandes, Aristela de Freitas Zanona, Beat Knechtle, Katja Weiss, Felipe J. Aidar, Raphael Fabricio de Souza
Summary: The acute effects of transcranial direct current stimulation (tDCS) on the running performance of 5000 m runners were examined. The study found that tDCS led to a decrease in running time and speed compared to sham stimulation, but no differences were observed in peak torque, perceived exertion, and internal load.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ali-Mohammad Kamali, Milad Kazemiha, Behnam Keshtkarhesamabadi, Mohsan Daneshvari, Asadollah Zarifkar, Prasun Chakrabarti, Babak Kateb, Mohammad Nami
Summary: This study investigated the effects of neuromodulation on professional boxers, demonstrating that transcranial direct current stimulation (tDCS) and transcutaneous spinal direct current stimulation (tsDCS) can improve athletic performance, specifically selective attention and reaction time. However, the intervention had no impact on cognitive functions. This suggests that simultaneous stimulation of the spinal cord and M1 may enhance the performance of experienced boxers through neuromodulation.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Nico Sollmann, Sandro M. Krieg, Laura Saisanen, Petro Julkunen
Summary: This article reviews the feasibility of motor mapping with navigated transcranial magnetic stimulation (nTMS) and provides evidence on factors that ensure methodological feasibility and accuracy of the motor mapping procedure. The selection of stimulation intensity (SI) for nTMS and spatial density of stimuli are crucial factors for accurately applying motor mapping. Despite the impressive spread of nTMS motor mapping over the past decade, variations in applied protocols and parameters still exist, which could be optimized for reliable quantitative mapping.
Review
Medicine, General & Internal
Daniel Marcos-Frutos, Virginia Lopez-Alonso, Irene Mera-Gonzalez, Jose Andres Sanchez-Molina, David Colomer-Poveda, Gonzalo Marquez
Summary: This systematic review examines the chronic effects of combining transcranial direct current stimulation (tDCS) and exercise on motor function and performance outcomes. The findings suggest that the chronic use of tDCS in combination with strength training does not enhance motor function in healthy adults. In neurological disorders, combining tDCS with exercise programs that include movements to be improved does not have an additive effect. However, in musculoskeletal conditions characterized by pain as a limiting factor of motor function, tDCS may enhance exercise-induced adaptations, although evidence is limited.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alireza Majdi, Luuk van Boekholdt, Saeed Sadigh-Eteghad, Myles Mc Laughlin
Summary: Transcranial direct-current stimulation (tDCS) appears to improve cognitive function in patients with Alzheimer's disease (AD), particularly in memory and general cognition. However, more high-quality studies with standardized parameters and measures are needed due to the limited number of studies and high heterogeneity of the data.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Evangelia G. Chrysikou, Hannah M. Morrow, Austin Flohrschutz, Lauryn Denney
Summary: Research on the impact of activity on innovative thinking has shown that cathodal stimulation of the left ventrolateral prefrontal cortex can improve fluency in generating creative ideas, while bilateral stimulation of the ventrolateral PFC and excitatory stimulation of the occipital cortex do not alter task performance. This highlights the importance of methodological consistency in experiments and expands our understanding of the role of the left PFC in creative thinking.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Peemongkon Wattananon, Khin Win Thu, Soniya Maharjan, Kanphajee Sornkaew, Hsing-Kuo Wang
Summary: Evidence suggests that patients with chronic low back pain have deficits in lumbar multifidus muscle activation and changes in cortical excitability. However, one-session of anodal transcranial direct current stimulation does not induce changes in cortical excitability and lumbar multifidus muscle activation. There is a moderate to strong correlation between peak-to-peak motor evoked potential amplitude and lumbar multifidus muscle activation.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Arsalan Mir-Moghtadaei, Shan H. Siddiqi, Kamran Mir-Moghtadaei, Daniel M. Blumberger, Fidel Vila-Rodriguez, Zafiris J. Daskalakis, Michael D. Fox, Jonathan Downar
Summary: The study aims to create a scalp heuristic for localizing the dorsolateral prefrontal cortex (DLPFC) based on convergent evidence of lesion and brain stimulation studies, and provides a calculation tool for this heuristic.
Article
Neurosciences
Julia P. Slopsema, Antonietta Canna, Michelle Uchenik, Lauri J. Lehto, Jordan Krieg, Lucius Wilmerding, Dee M. Koski, Naoharu Kobayashi, Joan Dao, Madeline Blumenfeld, Pavel Filip, Hoon-Ki Min, Silvia Mangia, Matthew D. Johnson, Shalom Michaeli
Summary: This study investigated the effects of direction and orientation of the electric field induced by VL-thalamus DBS on activity in the sensorimotor cortex using a swine animal model. Results showed that directional and orientation-selective stimulation could tune network-level modulation patterns in the sensorimotor cortex.
Article
Neurosciences
Henry Jeanvoine, Matthieu Labriffe, Thomas Tannou, Nastassia Navasiolava, Aram Ter Minassian, Jean-Baptiste Girot, Louis-Marie Leiber, Marc-Antoine Custaud, Cedric Annweiler, Mickael Dinomais
Summary: This study investigated the correlation between brain fMRI activation during simulated gait and age in healthy adults using an MRI-compatible system. The results showed age-correlated activity in areas associated with gait control, indicating a progressive loss of automation in healthy older adults.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Jusa Reijonen, Mervi Kononen, Pasi Tuunanen, Sara Maatta, Petro Julkunen
Summary: The study aimed to use atlas-based marking of cortical areas for nTMS targeting to achieve effects consistent with expert-selected target locations. In depression and schizophrenia patients, the selected targets were close to the border between atlas areas, while in other areas, the targets were consistent with treatment goals.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alberto Lema, Sandra Carvalho, Felipe Fregni, Oscar F. Goncalves, Jorge Leite
Summary: This study investigated the effects of transcranial stimulation on attentional networks, with tRNS showing significant improvement in attention performance, particularly in enhancing alerting and reducing conflict in complex situations.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Hanall Lee, Joon Ho Lee, Tae Lee Lee, Do-Kyung Ko, Nyeonju Kang
Summary: This study investigated the effectiveness of three different bilateral tDCS protocols on bimanual hand-grip force control capabilities in healthy young adults. The results showed that bilateral anodal stimulation significantly improved bilateral motor synergies, suggesting that promoting motor cortical activations between hemispheres is an additional option for enhancing interlimb coordination patterns.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Cell Biology
Sreerag Othayoth Vasu, Hanoch Kaphzan
Summary: Research indicates that weak subthreshold electrical fields can modify the conductance of voltage-dependent sodium channels in axon terminals, enhancing their membrane polarization and affecting synaptic functioning. Analytical modeling is employed to explain how modifications in sodium currents enhance axon terminal polarization.
Article
Neurosciences
Mahyar Firouzi, Kris Baetens, Manon Saeys, Catalina Duta, Chris Baeken, Frank Van Overwalle, Eva Swinnen, Natacha Deroost
Summary: In this study, the effects of conventional tDCS and high-definition tDCS on implicit motor sequence learning (IMSL) were compared. The results showed that conventional tDCS had positive effects on sequence-specific learning during the acquisition phase, but might have negative effects on long-term consolidation. On the other hand, high-definition tDCS had negative effects on sequence-specific learning during both the acquisition and long-term consolidation phases.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Rutvik Khakhar, Fang You, Denny Chakkalakal, David Dobbelstein, Thomas Picht
Summary: Two novel hands-free interaction concepts based on head positioning and gaze tracking were tested in microneurosurgery to reduce disruption and increase efficiency of the user. The study found that the new interaction concepts were faster and more preferable than the classical manual microscope adjustment.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Lucius S. Fekonja, Ziqian Wang, Dogu B. Aydogan, Timo Roine, Melina Engelhardt, Felix R. Dreyer, Peter Vajkoczy, Thomas Picht
Summary: A novel fixel-based along-tract analysis using diffusion MRI showed potential in identifying specific microstructural changes in the corticospinal tract of patients with gliomas infiltrating the motor system. However, traditional metrics like FA and ADC still showed higher sensitivity in detecting structural changes compared to the more complex FD metrics.
FRONTIERS IN ONCOLOGY
(2021)
Letter
Clinical Neurology
Anna L. Roethe, Thomas Picht
ACTA NEUROCHIRURGICA
(2021)
Article
Neurosciences
Melina Engelhardt, Darko Komnenic, Fabia Roth, Leona Kawelke, Carsten Finke, Thomas Picht
Summary: The study aimed to replicate the impact of functional connectivity between M1 and PMd on RMT and included additional predictors such as age, cortical gray matter volume, and CCD. The findings did not support the previously proposed role of PMd in modifying corticospinal excitability, but confirmed CCD as an important predictor with strong evidence.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Sebastian Ille, Anna Kelm, Axel Schroeder, Lucia E. Albers, Chiara Negwer, Vicki M. Butenschoen, Nico Sollmann, Thomas Picht, Peter Vajkoczy, Bernhard Meyer, Sandro M. Krieg
Summary: This study investigated the effect of postoperative nrTMS therapy on the unaffected hemisphere in glioma patients with acute surgery-related paresis of the upper extremity. Results showed significant improvement in outcomes compared to sham stimulation, with a focus on the Fugl-Meyer Assessment scale and the National Institutes of Health Stroke Scale. The findings suggest that low-frequency nrTMS stimulation therapy is beneficial for these patients in achieving a clinically important difference in upper extremity function.
Article
Clinical Neurology
Judith Roesler, Stefan Georgiev, Anna L. Roethe, Denny Chakkalakal, Gueliz Acker, Nora F. Dengler, Vincent Prinz, Nils Hecht, Katharina Faust, Ulf Schneider, Simon Bayerl, Marcus Czabanka, Martin Misch, Julia Onken, Peter Vajkoczy, Thomas Picht
Summary: This study investigated the clinical usability of a novel 3D4K exoscope in routine neurosurgical interventions, finding improved surgical ergonomics and overall user satisfaction. There were significant differences in the number of surgeries and the conversion rate between the two user groups.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Nicolas Schlinkmann, Rutvik Khakhar, Thomas Picht, Sophie K. Piper, Lucius S. Fekonja, Peter Vajkoczy, Gueliz Acker
Summary: The study compared traditional monoscopic and stereoscopic imaging for memorizing neurosurgical patient cases, finding that monoscopic imaging was subjectively superior in evaluating pathology but anatomical characterization was comparable between both methods. Most participants rated stereoscopic imaging as worse, likely due to lack of familiarity with the newer technique. However, stereoscopic imaging was not objectively inferior in anatomical comprehension compared to traditional monoscopic imaging. Further developments and integration into clinical workflows will likely enhance the usability and acceptance of stereoscopic visualization.
NEUROSURGICAL REVIEW
(2022)
Letter
Clinical Neurology
Clemens Neudorfer, Daniel Kroneberg, Bassam Al-Fatly, Lukas L. Goede, Dorothee Kuebler, Katharina Faust, Ursula van Rienen, Anna Tietze, Thomas Picht, Todd M. Herrington, Erik H. Middlebrooks, Andrea Kuehn, Gerd-Helge Schneider, Andreas Horn
ANNALS OF NEUROLOGY
(2022)
Editorial Material
Clinical Neurology
Giovanni Raffa, Thomas Picht, Andras Buki, Antonino Germano
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Tizian Rosenstock, Paul Poeser, David Wasilewski, Hans-Christian Bauknecht, Ulrike Grittner, Thomas Picht, Martin Misch, Julia Sophie Onken, Peter Vajkoczy
Summary: A recent study aimed to establish an MRI-based risk assessment for incomplete resection of brain metastases. The study found that subcortical metastases that are 5mm or more distant from the cortex and have diffuse contrast agent enhancement are the main risk factors for unintended subtotal resection (uSTR). The proposed MRI-based assessment allows estimation of the individual risk for uSTR and can guide intraoperative imaging.
FRONTIERS IN ONCOLOGY
(2022)
Review
Behavioral Sciences
Effrosyni Ntemou, Cheyenne Svaldi, Roel Jonkers, Thomas Picht, Adria Rofes
Summary: Transcranial magnetic stimulation(TMS) has been used to study the neural correlates of language, specifically verb and sentence processing. This systematic review and meta-analysis of 45 articles found that most studies focused on action verb embodiment, and frontal areas were most frequently stimulated for morphosyntactic processes and action verb semantics. Temporoparietal regions were most commonly stimulated for integration of sentential meaning and thematic role assignment. The overall effect size of TMS was small, but there was no difference in effect sizes between anterior and posterior regions for semantic or morphosyntactic contrasts.
Article
Oncology
Klara Reisch, Franziska Boettcher, Mehmet S. Tuncer, Heike Schneider, Peter Vajkoczy, Thomas Picht, Lucius S. Fekonja
Summary: This study compared the efficacy of a tractography-based nTMS language mapping protocol with a traditional perisylvian nTMS protocol, finding that the tractography-based method had significantly higher error rates and could more accurately locate language functional areas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Nicolas Hertzsprung, Kiril Krantchev, Thomas Picht, Anna L. L. Roethe, Kerstin Rubarth, Josch Fuellhase, Peter Vajkoczy, Gueliz Acker
Summary: This study aimed to investigate the usefulness of additional stereoscopic visualization of patient-specific imaging during informed consent conversation. The results showed that although there was no significant improvement in patients' objective understanding, patients perceived stereoscopic imaging as helpful and it potentially increased their confidence in treatment decisions.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Boshra Shams, Ziqian Wang, Timo Roine, Dogu Baran Aydogan, Peter Vajkoczy, Christoph Lippert, Thomas Picht, Lucius S. Fekonja
Summary: Shams et al. found that diffusion MRI metrics along the corticospinal tract can accurately predict the motor status of glioma patients, with a high overall accuracy. These microstructural measures are more effective than demographic and clinical variables for classifying and predicting functional deficits.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Luca L. Silva, Mehmet S. Tuncer, Peter Vajkoczy, Thomas Picht, Tizian Rosenstock
Summary: This study evaluates the clinical utility of different methods for DTI-FT of subcortical language pathways. Anatomical landmark-based approaches achieve the highest success and accuracy rates, while rTMS-based approaches frequently fail to reveal streamlines and provide less complete tractograms.
JOURNAL OF NEUROSURGERY
(2022)