Cytocompatibility of surface ground PE doped with calcium salt of 6-carboxycellulose

We studied the physical-chemical properties of polyethylene (PE) films doped with calcium salt of 6-carboxycellulose (Ca-oxy) in concentrations 0-20 wt.% and their interactions with cells. The interaction between the PE/Ca-oxy composite film and 3T3 cells has not been described so far. Modification by surface grinding to enhance material cytocompatibility was studied. The surface wettability of doped films was tested by contact angle measurements and the surface morphology by SEM microscopy and profilometry. Adhesion and proliferation of tissue cells (3T3 mouse fibroblasts) were studied in vitro on pristine and ground doped PE films. The ground samples have a higher contact angle values and the number of proliferated cells is greater on the ground samples than on pristine ones. The presence of Ca-oxy in PE film increases the adhesion of 3T3 cells on the doped substrate and on ground samples adhere more cells than on pristine ones.