Journal
ACS CHEMICAL NEUROSCIENCE
Volume 6, Issue 8, Pages 1309-1316Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.5b00149
Keywords
A beta 42 peptide; neuroprotective peptide; tubulin; microtubule; PC12 cell
Funding
- UGC, India
- DST, India
- CSIR, India [BSC0115]
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Herein, we report a novel hexapeptide, derived from activity dependent neuroprotective protein (ADNP), that spontaneously self-assembles to form antiparallel beta-sheet structure and produces nanovesicles under physiological conditions. This peptide not only strongly binds with) beta-tubulin in the taxol binding site but also binds with the microtubule lattice in vitro as well as in intracellular microtubule networks. Interestingly, it shows inhibition of amyloid fibril formation upon co-incubation with A beta peptide following an interesting mechanistic pathway and excellent neuroprotection in PC12 cells treated with anti-nerve growth factor (NGF). The potential of this hexapeptide opens up a new paradigm in design and development of novel therapeutics for AD.
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