Journal
CELLULAR SIGNALLING
Volume 26, Issue 1, Pages 49-55Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2013.09.015
Keywords
IL-1; Rac1; Endocytosis; Dynamin; Dynasore; NF-kappa B
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [WI3535/1-1]
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Interleukin 1 (IL-1) triggers the internalization of its cognate receptor from the plasma membrane. We recently demonstrated that this internalization is of critical importance for the IL-1-induced gene expression. In this study we report that the IL-1-induced activation of the small GTPase Rac1 requires receptor endocytosis. We further show that the depletion of Rac1 reduces the IL-1-dependent gene expression without affecting signaling events that are initiated at the plasma membrane. Collectively, we provide evidence for a key role of Rac1 in a pathway that regulates IL-1-induced gene expression depending on receptor endocytosis. (C) 2013 Elsevier Inc. All rights reserved.
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