Article
Multidisciplinary Sciences
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann
Summary: Mitochondrial dysfunction can induce epithelial mesenchymal transition in head and neck cancer cell lines, thereby promoting cancer aggressiveness and metastasis. However, this phenomenon is observed only in one of the cell lines.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Zhuomin Tan, Wenyan Sun, Ya Li, Xingmeng Jiao, Mingliang Zhu, Junfei Zhang, Chen Qing, Yinnong Jia
Summary: This article reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy.
Article
Cell Biology
Mao Shen, Runsang Pan, Shan Lei, Lu Zhang, Changhua Zhou, Zhirui Zeng, Yingjie Nie, Xiaobin Tian
Summary: This study found that the overexpression of potassium inwardly rectifying channel subfamily J member 2 (KCNJ2) is associated with advanced stage and high metastatic potential of osteosarcoma (OS), and poor prognosis. In OS cells, inhibition of KCNJ2 can suppress metastasis, while elevation of KCNJ2 has the opposite effects. KCNJ2 forms a positive feedback loop with HIF1 alpha, promoting the metastasis of OS cells. These findings may have significant implications for the diagnosis and treatment of OS.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Wojciech M. Ciszewski, Malgorzata Chmielewska-Kassassir, Lucyna A. Wozniak, Katarzyna Sobierajska
Summary: This study found a close correlation between TYMS and invasion ability in colon cancer cells, as well as its crucial role in EMT regulation. It suggests that chemotherapeutics targeting TYMS expression may enhance the effectiveness of colon cancer treatment, especially in the metastatic stage.
Article
Cell Biology
Yong Bian, Gang Yin, Gang Wang, Tiantian Liu, Li Liang, Xinyue Yang, Wen Zhang, Decai Tang
Summary: Curcumol inhibits epithelial-mesenchymal transition (EMT), invasion, and migration in colorectal cancer (CRC) cells by disrupting glutaminolysis and degrading hypoxia-inducible factor-1 alpha (HIF-1 alpha). The inhibitory effects of curcumol on EMT are mediated by the downregulation of glutaminase 1 (G1s1). Overexpression of HIF-1 alpha or G1s1 reverses the effects of curcumol on CRC growth, metastasis, and EMT.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Cell Biology
Yong Bian, Gang Yin, Gang Wang, Tiantian Liu, Li Liang, Xinyue Yang, Wen Zhang, Decai Tang
Summary: This study found that curcumol can inhibit EMT, invasion, and migration of CRC cells by disrupting glutaminolysis and stimulating the degradation of HIF-1 alpha. These findings suggest that curcumol may be a potential candidate for intervention in CRC metastasis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Hailong Hao, Huiqing Chen, Liwu Xie, Hongyu Liu
Summary: The study aimed to investigate the relationship between YKL-40 and recurrence and progression of bladder cancer, and to determine its potential as a therapeutic target. Results showed that YKL-40 promoted migration and invasion of bladder cancer cells, with its expression closely linked to the invasiveness and metastasis of bladder cancer.
ANNALS OF MEDICINE
(2021)
Article
Oncology
Hongtu Zheng, Shan Yu, Congcong Zhu, Tianan Guo, Fangqi Liu, Ye Xu
Summary: Chemoresistance in advanced CRC patients undergoing systemic chemotherapy is associated with increased recruitment of tumor-associated macrophages (TAMs) into the tumor. Activated HIF1 alpha signaling in CRC cells under chemotherapy drives the expression of HMGB1 to promote macrophage infiltration, leading to the development of chemoresistance. TAMs produce GDF15 which impairs the chemosensitivity of tumor cells. These findings provide new insights into potential drug targets for CRC treatment.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Hongyan Zhang, Jiangyang Chi, Jia Hu, Tiantian Ji, Zhen Luo, Caihong Zhou, Lifeng Huang, Zheng Dai, Jing Li, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study reveals the promoting role of intracellular AGR2 in CRC metastasis through activation of signaling pathways and regulation of gene expression. AGR2 can be upregulated by prostaglandin E2 (PGE2), and silencing of AGR2 enhances the therapeutic effects of COX-2 inhibitors in CRC metastasis.
Article
Cell Biology
Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou, Tang K. Tang
Summary: The study investigates the expression levels of centriolar/centrosomal genes in various types of cancers and identifies STIL as a protein that is highly expressed in lung and other types of cancers. Depletion of STIL inhibits tumor growth and metastasis, while excess STIL activates the EMT pathway and enhances cancer cell migration and invasion. The study reveals an unexpected role of STIL in tumor metastasis and identifies its association with FOXM1 in promoting metastasis and stemness.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiawei Sun, Zizhen Zhang, Jingyu Chen, Meng Xue, Xia Pan
Summary: High expression of ELTD1 is correlated with lymph node metastasis and poor outcomes in colorectal cancer, promoting invasion and metastasis of CRC both in vitro and in vivo. Additionally, ELTD1 accelerates MMP2 transcriptional activity, potentially serving as a novel target for CRC metastasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Lei Sun, Jia Yu, Justin Guinney, Bo Qin, Frank A. Sinicrope
Summary: ZEB1 is a transcription factor that promotes tumor invasion and metastasis through inducing epithelial-to-mesenchymal transition (EMT). In this study, the regulation of ZEB1 by RAS/RAF signaling and its posttranslation modification, including ubiquitination, were investigated. The interaction between ZEB1 and the deubiquitinase USP10 was identified in colorectal cancer cell lines with RAS/RAF/MEK/ERK activation, and it was found that USP10 modifies ZEB1 ubiquitination and promotes its degradation, contributing to the suppression of tumor metastasis.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kunhua Hu, Yufeng Ding, Hongwen Zhu, Xiaoqian Jing, Weiling He, Hua Yu, Xiongjun Wang
Summary: Tumor cells surviving hypoxic stress acquire the ability to drive cancer progression. Glutamate dehydrogenase 1 (GDH1) plays a critical role in regulating colorectal cancer (CRC) cell survival under hypoxia. GDH1 deficiency inhibits CRC occurrence and impairs hypoxia-inducible factor 1-alpha (HIF-1a) stability, promoting CRC progression through the modulation of GDH1 acetylation at K503 and K527.
Article
Multidisciplinary Sciences
Po-Hao Chang, Min-Che Chen, Ya-Ping Tsai, Grace Y. T. Tan, Pang-Hung Hsu, Yung-Ming Jeng, Yi-Fang Tsai, Muh-Hwa Yang, Wendy W. Hwang-Verslues
Summary: High expression of DSG2 promotes tumor growth, increases the prevalence of CTC clusters, and facilitates distant organ colonization. The dynamic regulation of DSG2 by hypoxia, with down-regulation in hypoxic regions of primary tumors leading to elevated EMT gene expression, allows cells to detach from the primary tumor and undergo intravasation. The derepression of DSG2 after intravasation and release of hypoxic stress is associated with increased ability to colonize distant organs, mediated by Hypoxia-Induced Factor1 alpha (HIF1 alpha).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
