Article
Pharmacology & Pharmacy
Ziyang Sun, Juehong Li, Gang Luo, Weixuan Liu, Yunwei He, Feiyan Wang, Yun Qian, Cunyi Fan
Summary: This study reveals that metformin can effectively attenuate trauma-induced heterotopic ossification by mitigating macrophage inflammatory responses through inhibiting NF-kappa B signaling via SIRT1-dependent mechanisms. These findings provide novel insights for future therapeutic investigations in trauma-related diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu, Guilin Zhang, Dong Wu, Youhua Xu
Summary: This study found that the SIRT1 agonist bergenin can improve asthma-induced airway inflammation and remodeling by activating SIRT1 and regulating the transcriptional activity of nuclear factor kappa B.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Hao-Min Wu, Chen-Yu Chiang, Wen-Ying Chen, Chun-Jung Chen, Ching-Chi Tseng, Yu-Chi Chang, Wen-Min Cheng, Yu-Hsiang Kuan
Summary: Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to its antihistaminic and antimuscarinic effects. However, it has the potential for abuse due to its hallucinogenic and euphoric effects. Overdose and illegal abuse of Cyclizine can result in confusion, tremors, chest pain, ataxia, seizures, and even suicide.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Zheng Zhao, Christoph Heier, Huimin Pang, Yu Wang, Feifei Huang, Pingan Chang
Summary: Phospholipase PNPLA7 suppresses M1 polarization of LPS-challenged macrophages by modulating SIRT1/NF-κ B and p38 MAPK-dependent pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bin Lin, Hui Zhao, Li Li, Zhenzhen Zhang, Nan Jiang, Xiaowei Yang, Tao Zhang, Bowen Lian, Yaokai Liu, Chi Zhang, Jiaxiang Wang, Feng Wang, Deguang Feng, Jing Xu
Summary: The findings suggest that Sirt1 plays a role in alleviating heart failure in rats through the NF-kappa B p65/miR-155/BDNF signaling cascade. Inhibition of Sirt1 increased acetylation of NF-kappa B p65, leading to elevated NF-KB p65 expression, while silencing NF-kappa B p65 improved heart functions and reduced cardiomyocyte apoptosis.
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Plant Sciences
Mengran Zhao, Chen Qiao, Zilu Cui, Wen Zhang, Shuyue Yang, Congmin Zhu, Feng Du, Tingting Ning, Sian Xie, Si Liu, Peng Li, Junxuan Xu, Shengtao Zhu
Summary: This study demonstrates that Moluodan (MLD) has an obvious hemostatic effect but exacerbates the severity of inflammation in a mouse model of colitis by promoting macrophage polarization towards the M1 phenotype.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Immunology
Yongli Pan, Ting Wang, Zhiqiang Zhao, Wei Wei, Xinyu Yang, Xianbin Wang, Wenqiang Xin
Summary: This article reviews the regulation of Neat1 and its modulation of target gene expression, and explores the impact of Neat1 on inflammation, including activation or inhibition of various signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Min Jo Kim, Dae Hyun Kim, EunJin Bang, Sang Gyun Noh, Pusoon Chun, Takako Yokozawa, Hyung Ryong Moon, Hae Young Chung
Summary: MHY3200 shows beneficial effects on oxidative stress and inflammation in aging rats, by reducing ROS levels, inhibiting NF-κB activation, and regulating the FoxO1 signaling pathway.
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chenghao Ren, Jie Jin, Wei Hu, Qi Chen, Jian Yang, Yaosen Wu, Yifei Zhou, Liaojun Sun, Weiyang Gao, Xiaolei Zhang, Naifeng Tian
Summary: The study showed that betulin can suppress inflammation induced by IL-1 beta and alleviate cartilage inflammation, acting through the activation of the AKT/Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiao Lan, Ke Li, Austin Gresham, Jifei Miao
Summary: The study found that TSS exerts anti-inflammatory effects by upregulating circ-Sirt1 expression to inhibit the translocation of NF-kappa B. In vivo experiments confirmed the protective function of TSS on inflammation, suggesting that TSS may be a potential treatment for inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Zhousheng Yang, Tianyu Li, Chunyan Wang, Mingyu Meng, Shenglan Tan, Lei Chen
Summary: Dihydromyricetin (DMY), a natural flavonoid compound extracted from Ampelopsis grossedentata, has been identified as a potential therapeutic chemical for treating atherosclerosis. This study investigates the mechanism by which DMY suppresses M1 macrophage polarization in atherosclerosis. The results showed that DMY treatment significantly reduced M1 macrophage markers and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe(-/-)) mice.
MEDIATORS OF INFLAMMATION
(2023)