Article
Medicine, Research & Experimental
Keqin Zhou, Yongbao Wei, Xurui Li, Xin Yang
Summary: The study found that miR-223-3p is significantly upregulated in clinically collected urine samples and PCa cells with low radiosensitivity. Enhancing miR-223-3p further reduces radiosensitivity, while inhibiting miR-223-3p improves radiosensitivity of PC3 and LNCaP cells. miR-223-3p regulates radiosensitivity by enhancing cell glycolysis.
Article
Cell Biology
Jun Hong, Shijing Mo, Fangxiao Gong, Zongbin Lin, Hanhui Cai, Ziqiang Shao, Xianghong Yang, Renhua Sun, Qiangnu Zhang, Jingquan Liu
Summary: This study investigated the functional role of the lncRNA-SNHG14/miR-223-3p/Foxo3a pathway in LPS-induced ALI and found that lncRNA-SNHG14 may serve as a potential therapeutic target by regulating autophagy through controlling miR-223-3p/Foxo3a.
MEDIATORS OF INFLAMMATION
(2021)
Review
Immunology
Shun Yuan, Qi Wu, Zhiwei Wang, Yanjia Che, Sihao Zheng, Yuanyang Chen, Xiaohan Zhong, Feng Shi
Summary: miR-223 is a crucial microRNA that plays important regulatory roles in the immune response, with abnormal expression associated with various infectious diseases such as viral hepatitis, HIV-1, and tuberculosis. The understanding of miR-223 physiopathology and its molecular mechanism in regulating immune responses to infectious diseases could lead to targeted diagnosis and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Review
Medicine, General & Internal
Mingyu Shi, Qianying Lu, Yanmei Zhao, Ziling Ding, Sifan Yu, Junfeng Li, Mengjun Ji, Haojun Fan, Shike Hou
Summary: Small noncoding RNAs, microRNAs (miRNAs), play a crucial role in regulating various biological processes. The miRNA miR-223, which is expressed in myeloid lineage cells, is conserved throughout evolution and involved in the regulation of monocyte-macrophage differentiation, proinflammatory responses, and neutrophil recruitment. This review outlines the regulatory role of miR-223 in different cell types and summarizes its potential role in pulmonary inflammatory diseases such as COPD, ALI, COVID-19, providing insights into the molecular regulatory networks in these diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
My-Anh Nguyen, Huy-Dung Hoang, Adil Rasheed, Anne-Claire Duchez, Hailey Wyatt, Mary Lynn Cottee, Tyson E. Graber, Leah Susser, Sabrina Robichaud, Ibrahim Berber, Michele Geoffrion, Mireille Ouimet, Hilal Kazan, Lars Maegdefessel, Erin E. Mulvihill, Tommy Alain, Katey J. Rayner
Summary: miR-223 acts as a key regulator in macrophages, protecting against atherosclerosis by modulating cholesterol metabolism and inflammation pathways.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Article
Neurosciences
Li Wu, Qian Xu, Mengxi Zhou, Yajing Chen, Chunyan Jiang, Yuhan Jiang, Yin Lin, Qing He, Lei Zhao, Yourong Dong, Jianren Liu, Wei Chen
Summary: Plasma levels of miR-153 and miR-223 were found to be significantly decreased in Parkinson's disease patients. MiR-153 levels were closely associated with disease duration and clinical phenotype, while miR-223 levels were linked to the presence of rapid eye movement sleep behavior disorder. These miRNAs could potentially serve as biomarkers for Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Immunology
Jiarong Gu, Hao Xu, Yandong Chen, Na Li, Xin Hou
Summary: This article reviews the biosynthesis and functions of miR-223 in innate immunity, highlighting its key role in inflammatory diseases and cancers. Furthermore, it discusses the potential role of miR-223 in liver physiopathology and therapeutic prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Evan E. E. Santo, Rasmus Ribel-Madsen, Peter J. J. Stroeken, Vincent C. J. de Boer, Ninna S. S. Hansen, Maaike Commandeur, Allan A. A. Vaag, Rogier Versteeg, Jihye Paik, Ellen M. M. Westerhout
Summary: This study identified a primate-specific transcriptional isoform named FOXO3A-Short (FOXO3A-S) in FOXO3A that is associated with human longevity. The study found that a specific SNP within the FOXO3A-S mRNA, rs9400239, influences the stability and functionality of the encoded protein. Carriers of the longevity T-allele have faster glucose clearance rates and longer lifespans.
Review
Biochemistry & Molecular Biology
Peng Jiao, Xing-Ping Wang, Zhuo-Ma Luoreng, Jian Yang, Li Jia, Yun Ma, Da-Wei Wei
Summary: miR-223 is an important miRNA that plays a critical role in various biological processes such as cell differentiation and immune modulation. It is regulated by different transcription factors and mediates its biological functions through changes in cellular or tissue expression. miR-223 is involved in regulating the differentiation of granulocytes, dendritic cells, as well as inflammation in diseases like lung inflammation and rheumatoid arthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lorenzo Agostino Citterio, Roberta Mancuso, Simone Agostini, Mario Meloni, Mario Clerici
Summary: The etiology of Parkinson's disease is still unclear, but it is likely to involve both genetic and environmental factors. Studies have found dysregulated microRNA expression, specifically increased levels of miR-7-1-5p and miR-223-3p in the serum of Parkinson's patients, suggesting that these microRNAs could potentially serve as diagnostic biomarkers.
Article
Genetics & Heredity
Marcia Maria U. Castanhole-Nunes, Nathalia M. Tunissiolli, Andre R. C. P. Oliveira, Marlon F. Mattos, Ana Livia S. Galbiatti-Dias, Rosa S. Kawasaki-Oyama, Erika C. Pavarino, Renato F. da Silva, Eny M. Goloni-Bertollo
Summary: MicroRNAs (miRNAs) play important roles in regulating posttranscriptional gene and protein expression in cancer. In this study, the researchers investigated the expression of VEGFA, a key protein involved in vascular endothelial growth, in hepatocellular carcinoma (HCC) cell lines after transfection with miR-612, miR-637, or miR-874. The results showed that miR-612 and miR-637 downregulated the gene and protein expression of VEGFA in both HCC cell lines. However, the modulation of VEGFA by miR-874 was observed only at the gene expression level and further investigation is needed.
Article
Biochemistry & Molecular Biology
Sung-Hwan Cho, Ji-Hyang Kim, Hui-Jeong An, Young-Ran Kim, Eun-Hee Ahn, Jung-Ryeol Lee, Jung-Oh Kim, Jung-Jae Ko, Nam-Keun Kim
Summary: The study identified an association between polymorphisms in miR-604A>G and miR-938G>A and the risk of idiopathic recurrent pregnancy loss (RPL), suggesting potential effects on RPL in Korean women. The results indicate that these miRNA polymorphisms may play a role in RPL susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)