Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 29, Issue 5-6, Pages 705-712Publisher
KARGER
DOI: 10.1159/000178590
Keywords
Systemic lupus erythematosus; Bone marrow mesenchymal stem cell; Transplantation; Cell cycle; Akt; GSK3 beta
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Funding
- National Natural Science Foundation of China [30972661]
- Science and Technology Foundation of Guangdong Province [2010B031600214]
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by activation and proliferation of autoreactive T cells and B cells. We examined changes in cell cycle progression of T cells from MRL/lpr mice with or without allogenic bone marrow mesenchymal stem cells (BMMSCs) treatment and analyzed the expression of cell cycle associated proteins. In addition, the Akt/GSK3 beta protein kinase cascade was studied. We demonstrated that high-dose MSCs transplantation effectively ameliorated disease activity in MRL/lpr mice. BMMSCs treatment inhibited G1/S transition of the abnormal lupus T lymphocytes. Moreover, it increased the expression of p21(WAF1/CIP1) and p27(Kip1) and decreased the expression of CDK2. Furthermore, high-dose MSCs inhibited abnormal activation of the Akt/GSK3 beta signaling pathway of T cells from MRL/lpr mice. Our results suggest that high-dose BMMSCs transplantation successfully treated MRL/lpr lupus mice by inhibiting abnormal activation of Akt/GSK3 beta signaling pathway of T cells. Copyright (c) 2012 S. Karger AG, Basel
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