Article
Biochemistry & Molecular Biology
Asfree Gwanyanya, Inga Andriule, Bogdan M. Istrate, Farjana Easmin, Kanigula Mubagwa, Regina Macianskiene
Summary: TRPM6 and TRPM7 proteins in the heart may be the molecular candidates for native cardiac Mg2+-sensitive channels, potentially influencing the duration of action potentials and having implications in arrhythmogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Janet Juarez-Escobar, Esau Bojorquez-Velazquez, Jose M. Elizalde-Contreras, Jose A. Guerrero-Analco, Victor M. Loyola-Vargas, Martin Mata-Rosas, Eliel Ruiz-May
Summary: Embryogenesis is a crucial developmental program in plants, with research gaps in understanding the mechanisms regulating somatic embryogenesis (SE) and zygotic embryogenesis (ZE). Studies on ZE are limited, while SE research efforts are substantial but disjointed, potentially hindering efficient large-scale plant regeneration. Comprehensive and integrative studies of both SE and ZE are needed to address these challenges and provide a molecular foundation for plant embryogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander P. Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P. de Boer, Gary R. Mirams, David J. Christini, Trine Krogh-Madsen
Summary: The aim of this study is to understand the effect of seal-leak current on recordings of action potential morphology in human iPSC-CMs. The results show that seal-leak current depolarizes action potentials, significantly affecting their morphology, and the accurate measurement of seal-leak current presents challenges. The authors recommend improving the compensation of seal-leak current during data acquisition to enhance the descriptive ability of the models.
Review
Plant Sciences
Rainer Hedrich, Ines Kreuzer
Summary: All plants have electrical excitability, but only few can produce a well-defined action potential (AP). The Venus flytrap Dionaea muscipula is able to generate APs with a high firing frequency and speed, allowing it to catch small animals quickly. The captured prey triggers a certain number of APs, which influences the trapping decisions made by the flytrap. The typical Dionaea AP lasts 1 second and consists of five phases, each controlled by specific ion channels, pumps, and carriers.
Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Article
Chemistry, Multidisciplinary
Jung-Soo Kim, Jongwoon Kim, Jinchul Ahn, Seok Chung, Chang-Soo Han
Summary: The cell-inspired ionic power device successfully utilizes the Donnan effect to generate high ionic currents and reduce the osmotic imbalance of the membrane. By implementing a mechanical switching system similar to mechanosensitive ion channels, it presents artificial neuronal signaling. Compared to reverse electrodialysis, this device achieves ten times the current and 8.5 times the power density, demonstrating the potential of an ion-based artificial nervous system.
Article
Biochemistry & Molecular Biology
Lin Chen, Jia Xin, Heyun Song, Fei Xu, Hui Yang, Heng Sun, Mei Yang
Summary: In this study, 57 putative LEA genes were identified in lotus, indicating their important roles in seed development and involvement in ABA signaling and seed maturation processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Poornima P. Vijayan, P. G. Chithra, Anjana S. Krishna, E. B. Ansar, Jyotishkumar Parameswaranpillai
Summary: Ion-exchange materials are widely used in the separation and purification industry, playing significant roles in various fields of modern society. This review focuses on the developments and latest trends in different kinds of ion-exchange materials, discussing the fundamental concepts, classifications, and research progresses of composite and nanocomposite ion exchangers. The review concludes with the potential applications of ion exchangers in next-generation clean energy technologies and the challenges for sustainable development.
SEPARATION AND PURIFICATION REVIEWS
(2022)
Review
Oncology
Linna Sheng, Jiaxuan Li, Shengfang Rao, Zhijun Yang, Yonghong Huang
Summary: CDK5RAP3 is a protein involved in crucial cellular processes and plays important roles in embryonic and tissue development as well as the onset and progress of human cancers. Despite the unclear detailed function and mechanism, understanding CDK5RAP3 may provide insights for novel therapeutic opportunities targeting CDK5RAP3-related diseases.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Preeti Kushwaha, Vipin Kumar, Biswajit Saha
Summary: beta-Carboline alkaloids are important nitrogen-based natural alkaloids and therapeutic molecules that exhibit various pharmacological activities through diverse mechanisms. There has been increasing attention towards developing effective antimalarial drugs based on this compound. This article comprehensively reviews the clinical and preclinical antimalarial scaffolds containing beta-carboline structure. The study focuses on the natural and semi-synthetic analogues of beta-carbolines reported in the last decade (2011-2021), providing insights into their mechanisms of action and potential for future therapeutic development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Michael D. Nodine
Summary: Parental contributions affect early embryogenesis by regulating maternal resources distribution to offspring. A new study in Arabidopsis thaliana shows that signaling components from maternal sporophytic tissues and paternal gametes converge in zygotes to promote elongation of the extraembryonic suspensor, supporting embryo development.
Review
Plant Sciences
Lucija Markulin, Andreja Skiljaica, Mirta Tokic, Mateja Jagic, Tamara Vuk, Natasa Bauer, Dunja Leljak Levanic
Summary: The article discusses the importance of DNA methylation during plant embryogenesis, with a focus on the regulatory role of RNA-directed DNA methylation (RdDM) and its involvement in both zygotic and somatic embryogenesis. It highlights the mechanism of RdDM in silencing transposons and establishing genome stability in developing embryos, as well as its potential global mechanism of transcription control during developmental transitions.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Reproductive Biology
Jessica Romero-Reyes, Anayansi Molina-Hernandez, Nestor Fabian Diaz, Ignacio Camacho-Arroyo
Summary: Serotonin, discovered in 1937, plays a predominant role in regulating physiological processes such as mood, sleep, and food intake. It is present in almost all cells of the body and has been observed in various vertebrates during oocyte and embryo development stages, suggesting its participation in vertebrate embryo development.
REPRODUCTIVE BIOLOGY
(2021)
Article
Physiology
A. B. Carvalho, Keyla Cristiny da Silva Coutinho, Raiana Andrade Quintanilha Barbosa, Dilza Balteiro Pereira de Campos, Isabela de Carvalho Leitao, R. S. Pinto, D. Silva Dos Santos, Bruna Farjun, Dayana da Silva De Araujo, Fernanda Cristina Paccola Mesquita, G. Monnerat-Cahli, E. H. Medei, Tais Hanae Kasai-Brunswick, A. C. Campos De Carvalho
Summary: This article investigates the action potential variability of cardiomyocytes derived from pluripotent stem cells obtained from multiple healthy donors. The study finds that even using the same cell line and differentiation protocol, the differentiation batch still affects the results. This has important implications in modeling arrhythmias and studying the pathogenicity of variants associated with them.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Green & Sustainable Science & Technology
Christian Kimmich, Melf-Hinrich Ehlers, Elke Kellner, Christoph Oberlack, Andreas Thiel, Sergio Villamayor-Tomas
Summary: This special feature summarizes the research using the Network of Action Situations (NAS) approach to study decision-making and agency in social-ecological systems. The article emphasizes the value of accurately reconstructing relations using NAS and maintaining consistency in analysis methods. Key themes discussed include complementarity and disconnects between situations, temporality of NAS, and the analysis of power in SES. Further suggestions are made to expand on the relational turn, develop NAS archetypes, and study polycentric governance using NAS.
SUSTAINABILITY SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Finn Holler, Tobias Hannes, Ingo Germund, Mathias Emmel, Heike Hoyer-Kuhn, Markus Khalil, Narayanswami Sreeram, Floris E. A. Udink ten Cate
CARDIOLOGY IN THE YOUNG
(2016)
Article
Cell Biology
Tobias Hannes, Marie Wolff, Michael Xavier Doss, Kurt Pfannkuche, Moritz Haustein, Jochen Mueller-Ehmsen, Agapios Sachinidis, Juergen Hescheler, Markus Khalil, Marcel Halbach
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Cardiac & Cardiovascular Systems
Floris E. A. Udink ten Cate, Tobias Hannes, Ingo Germund, Markus Khalil, Michael Huntgeburth, Christian Apitz, Konrad Brockmeier, Narayanswami Sreeram
Article
Cell & Tissue Engineering
Jan Trieschmann, Daniel Bettin, Moritz Haustein, Annette Koester, Marek Molcanyi, Marcel Halbach, Mira Hanna, Mariam Fouad, Konrad Brockmeier, Juergen Hescheler, Kurt Pfannkuche, Tobias Hannes
STEM CELLS INTERNATIONAL
(2016)
Review
Cell Biology
Kurt Pfannkuche, Tobias Hannes, Markus Khalil, Monireh Soroush Noghabi, Amir Morshedi, Juergen Hescheler, Peter Droege
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Jiaoya Xi, Markus Khalil, Nava Shishechian, Tobias Hannes, Kurt Pfannkuche, Huamin Liang, Azra Fatima, Moritz Haustein, Frank Suhr, Wilhelm Bloch, Michael Reppel, Tomo Saric, Marius Wernig, Rudolf Jaenisch, Konrad Brockmeier, Juergen Hescheler, Frank Pillekamp
Article
Cardiac & Cardiovascular Systems
Marcel Halbach, Benjamin Krausgrill, Tobias Hannes, Mirjam Wiedey, Gabriel Peinkofer, Sven Baumgartner, Raja Ghazanfar Ali Sahito, Kurt Pfannkuche, Frank Pillekamp, Michael Reppel, Jochen Mueller-Ehmsen, Juergen Hescheler
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2012)
Article
Multidisciplinary Sciences
Moritz Haustein, Tobias Hannes, Jan Trieschmann, Rabea Verhaegh, Annette Koester, Juergen Hescheler, Konrad Brockmeier, Roland Adelmann, Markus Khalil
Review
Biochemistry & Molecular Biology
T. A. Quinn, S. Granite, M. A. Allessie, C. Antzelevitch, C. Bollensdorff, G. Bub, R. A. B. Burton, E. Cerbai, P. S. Chen, M. Delmar, D. DiFrancesco, Y. E. Earm, I. R. Efimov, M. Egger, E. Entcheva, M. Fink, R. Fischmeister, M. R. Franz, A. Garny, W. R. Giles, T. Hannes, S. E. Harding, P. J. Hunter, G. Iribe, J. Jalife, C. R. Johnson, R. S. Kass, I. Kodama, G. Koren, P. Lord, V. S. Markhasin, S. Matsuoka, A. D. McCulloch, G. R. Mirams, G. E. Morley, S. Nattel, D. Noble, S. P. Olesen, A. V. Panfilov, N. A. Trayanova, U. Ravens, S. Richard, D. S. Rosenbaum, Y. Rudy, F. Sachs, F. B. Sachse, D. A. Saint, U. Schotten, O. Solovyova, P. Taggart, L. Tung, A. Varro, P. G. Volders, K. Wang, J. N. Weiss, E. Wettwer, E. White, R. Wilders, R. L. Winslow, P. Kohl
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2011)
Article
Cell & Tissue Engineering
Jiaoya Xi, Markus Khalil, Dimitry Spitkovsky, Tobias Hannes, Kurt Pfannkuche, Wilhelm Bloch, Tomo Saric, Konrad Brockmeier, Juergen Hescheler, Frank Pillekamp
STEM CELLS AND DEVELOPMENT
(2011)
Article
Cell & Tissue Engineering
Martin Rubach, Roland Adelmann, Moritz Haustein, Florian Drey, Kurt Pfannkuche, Bing Xiao, Annette Koester, Floris E. A. Udink ten Cate, Yeong-Hoon Choi, Klaus Neef, Azra Fatima, Tobias Hannes, Frank Pillekamp, Juergen Hescheler, Tomo Saric, Konrad Brockmeier, Markus Khalil
STEM CELLS AND DEVELOPMENT
(2014)
Article
Neurosciences
Marek Molcanyi, Narges Zare Mehrjardi, Ute Schaefer, Nadia Nabil Haj-Yasein, Michael Brockmann, Marina Penner, Peter Riess, Clemens Reinshagen, Bernhard Rieger, Tobias Hannes, Juergen Hescheler, Bert Bosche
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Cell & Tissue Engineering
Jan Trieschmann, Moritz Haustein, Annette Koester, Juergen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes
STEM CELLS INTERNATIONAL
(2019)
Article
Pediatrics
Nicolas Leister, Daniel Rohe, Christine Schumacher, Uwe Trieschmann, Christoph Menzel, Tobias Hannes
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2020)