Article
Mathematics
Mohammed Balubaid, Osman Taylan, Mustafa Tahsin Yilmaz, Ehsan Eftekhari-Zadeh, Ehsan Nazemi, Mohammed Alamoudi
Summary: The Central Nervous System (CNS) is a vital part of the nervous system that comprises the brain and spinal cord. Researchers have proposed a modified version of a neuronal model using a quadratic-based modeling called Digital Spiking Silicon Neuron (DSSN), which can imitate the basic behaviors of the original model. The hardware implementation of the new model shows high similarity with the original model in terms of neuronal behaviors, as well as achieving higher frequency and lower cost conditions.
Review
Physiology
Jing Yan, Xiaole Tang, Zhi-qiang Zhou, Jie Zhang, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: SIRTs are a class of NAD+-dependent deacylases that regulate cell functions. CNS decline leads to impaired cognitive and social abilities, so understanding potential targets to promote CNS homeostasis is crucial.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Boyi Zong, Fengzhi Yu, Xiaoyou Zhang, Yige Pang, Wenrui Zhao, Peng Sun, Lin Li
Summary: Since the discovery of the mechanosensitive Piezo1 channel in 2010, research has been conducted to explore its role in various organ systems. Recent evidence links the activity of Piezo1 channel to the central nervous system. This review systematically summarizes current research on the channel, its implications for central nervous system mechanobiology, and its involvement in disorders.
AGEING RESEARCH REVIEWS
(2023)
Review
Endocrinology & Metabolism
Yiqi Christina Lin, Vassilios Papadopoulos
Summary: Neurosteroids, synthesized locally in the nervous system, have important neuromodulatory and neuroprotective effects. Research suggests differences in steroidogenesis between the nervous system and the periphery, particularly in the presence of the enzyme CYP11A1. Further understanding of neurosteroidogenesis is crucial for future neurosteroid-based therapies.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Junjun Ni, Fei Lan, Yan Xu, Hiroshi Nakanishi, Xue Li
Summary: This review summarizes the physiological and pathological functions of CatB in the central nervous system and discusses its potential therapeutic applications.
Review
Cell Biology
Andrea Nortey, Kimberly Garces, Abigail Hackam
Summary: Interleukin-27 is a pleiotropic cytokine involved in immune responses and neuroprotection. It has regulatory effects on cell survival and inflammation in neurodegenerative diseases. Its role in promoting neuronal survival is mediated through the regulation of cytokines, neuroinflammatory pathways, and oxidative stress.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Paulo F. Santos, Beatriz Fazendeiro, Francis C. Luca, Antonio Francisco Ambrosio, Helene Leger
Summary: Nuclear Dbf2-related (NDR) kinases are a subgroup of AGC protein kinases that regulate cell growth and morphogenesis. They play important roles in the Hippo pathway and have emerging roles in the regulation of retinal/neuronal function and homeostasis. NDR1 and NDR2 kinases may have potential as therapeutic targets for neuronal diseases and their regulation of neuronal inflammation is highlighted.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Han Su, Ning Liu, Yalin Zhang, Juan Kong
Summary: This study demonstrates that vitamin D may impact energy homeostasis in the central nervous system by modulating the renin-angiotensin system activity. In Cyp27b1(-/-) mice, enhanced RAS activity led to increased metabolic rate, while in the VD-treated group, there was a slightly inhibited metabolic rate due to reduced RAS and sympathetic nerve activities.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Neurosciences
Paul A. A. Constable, Jeremiah K. H. Lim, Dorothy A. A. Thompson
Summary: The retina and brain have similar neurochemistry and neurodevelopmental origins. Retinal findings are being used as potential biomarkers for central nervous system disorders. Despite limitations, functional retinal biomarkers show promise in neurological disorders. This review summarizes functional retinal findings, retinal neurotransmitters, and electrophysiological tests, and suggests that future applications of signal analysis and machine learning algorithms could provide new insights into the pathophysiology and classification of various clinical disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Guenaelle Lizot, Come Pasqualin, Audrey Tissot, Stephane Pages, Jean-Francois Faivre, Aurelien Chatelier
Summary: This study provides a characterization of the mouse ICNS in terms of phenotype, electrophysiology, and pharmacology. It reveals the neurochemical diversity of this network and identifies different neuronal populations based on their electrical behavior.
Review
Neurosciences
Ellen A. Wood, Sylwia A. Stopka, Linwen Zhang, Sara Mattson, Gabor Maasz, Zsolt Pirger, Akos Vertes
Summary: The great pond snail Lymnaea stagnalis is a well-established model organism with a simple central nervous system that has been extensively used to study neural functioning. Through electrophysiological experiments and mass spectrometry techniques, researchers have mapped neuronal connections and identified circuits responsible for basic life functions. This combination of techniques has led to increasing insights into the molecular basis of CNS-controlled biological functions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Obstetrics & Gynecology
Thu Yen Thi Nguyen, Luciana Cacciottola, Alessandra Camboni, Joachim Ravau, Michel De Vos, Isabelle Demeestere, Jacques Donnez, Marie-Madeleine Dolmans
Summary: The study did not detect malignancy reseeding in cryopreserved ovarian tissue from 20 patients with CNS tumors, indicating a lack of tumor seeding in frozen-thawed and xenografted tissue.
HUMAN REPRODUCTION
(2021)
Letter
Oncology
Yoshiko Okita, Rieko Kano-Fujiwara, Shin-Ichi Nakatsuka, Keiichiro Honma, Manabu Kinoshita
Summary: Tirabrutinib is a newly developed drug that has been pathologically confirmed to be effective in treating relapsed/refractory PCNSL in humans. Autopsy results showed complete obliteration of brain tumors in the patient.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Cell Biology
Zuliyaer Talifu, Jia-Yi Liu, Yun-Zhu Pan, Han Ke, Chun-Jia Zhang, Xin Xu, Feng Gao, Yan Yu, Liang-Jie Du, Jian-Jun Li
Summary: The inability of damaged neurons to regenerate within the mature central nervous system (CNS) is a significant neuroscientific challenge. Recent studies have shown that astrocytes, a component of the CNS, can be reprogrammed to become functional neurons in different disease models. However, controversy exists regarding the source of these new neurons. This review summarizes progress in reprogramming astrocytes into neurons in vivo in animal models of various neurodegenerative conditions.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Maninder Malik, Claudia Rangel-Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren-Qi Huang, Johann Meunier, Tangui Maurice, Robert H. Mach, Robert R. Luedtke
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Christian Madry, David Attwell
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Review
Neurosciences
E. B. Engler-Chiurazzi, M. Singh, J. W. Simpkins
Article
Endocrinology & Metabolism
Fen Sun, Trinh Nguyen, Xin Jin, Renqi Huang, Zhenglan Chen, Rebecca L. Cunningham, Meharvan Singh, Chang Su
Article
Neurosciences
Ivana Mesic, Christian Madry, Kirsten Geider, Max Bernhard, Heinrich Betz, Bodo Laube
Article
Pharmacology & Pharmacy
Douglas Bledsoe, Ceyhun Tamer, Ivana Mesic, Christian Madry, Bradley G. Klein, Bodo Laube, Blaise M. Costa
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Neurosciences
Christian Madry, Vasiliki Kyrargyri, I. Lorena Arancibia-Carcamo, Renaud Jolivet, Shinichi Kohsaka, Robert M. Bryan, David Attwell
Article
Multidisciplinary Sciences
Christian Madry, I. Lorena Arancibia-Carcamo, Vasiliki Kyrargyri, Victor T. T. Chan, Nicola B. Hamilton, David Attwell
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Trinh Nguyen, Chang Su, Meharvan Singh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Neurosciences
Pablo Izquierdo, David Attwell, Christian Madry
TRENDS IN NEUROSCIENCES
(2019)
Article
Multidisciplinary Sciences
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, David Attwell
Article
Neurosciences
Vasiliki Kyrargyri, Christian Madry, Ali Rifat, I. Lorena Arancibia-Carcamo, Steffan P. Jones, Victor T. T. Chan, Yajing Xu, Bernard Robaye, David Attwell
Article
Biochemistry & Molecular Biology
Harshavardhan Kenche, Meharvan Singh, Jacquez Smith, Kai Shen
Summary: Disruption of circadian rhythm leads to mitochondrial dysfunction, while the sigma-1 receptor agonist donepezil can restore mitochondrial function and rhythmicity of core clock genes, suggesting a novel treatment approach for related neurodegenerative diseases and mental disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Benjamin Grimmer, Adrienn Krauszman, Xudong Hu, Golam Kabir, Kim A. Connelly, Mei Li, Jana Grune, Christian Madry, Brant E. Isakson, Wolfgang M. Kuebler
Summary: This study identifies Panx1 as a novel regulator of HPV, but its role is not necessarily linked to ATP release and downstream signaling via P2Y receptors or TRPV4 activation. Instead, Panx1 appears to modulate the Ca2+ response of PASMC to hypoxia. Furthermore, Panx1 does not affect the development of chronic hypoxic PH.
CARDIOVASCULAR RESEARCH
(2022)
Article
Neurosciences
Bernardino Ossola, Ali Rifat, Anna Rowland, Helen Hunter, Samuel Drinkall, Clare Bender, Mayida Hamlischer, Martin Teall, Russell Burley, Daneil F. Barker, David Cadwalladr, Louise Dickson, Jason M. K. Lawrence, Jenna R. M. Harvey, Marina Lizio, Xiao Xu, Edel Kavanagh, Toni Cheung, Steve Sheardown, Catherine B. Lawrence, Michael Harte, David Broughe, Christian Madry, Kim Matthews, Kevin Doyle, Keith Page, Justin Powell, Nicola L. Brice, Roland W. Buerli, Mark B. Carlton, Lee A. Dawson
Summary: Neuroinflammation, particularly through the NLRP3 inflammasome cascade, plays a significant role in neurodegenerative diseases. The upregulation of THIK-1 in isolated microglia from the brains of Alzheimer's disease patients and the selective inhibitor C101248 can attenuate the release of IL-1 beta from microglia, suggesting THIK-1 as a potential therapeutic target for neuroinflammation modulation in AD.
