Review
Cell Biology
Ming-Yun Ho, Chao-Yung Wang
Summary: Irisin plays a vital role in regulating cardiovascular functions, with both protective and detrimental effects depending on the stage of myocardial infarction. Its functions include modulation of mitochondrial dysfunction, oxidative stress, metabolic imbalance, and energy expenditure in heart failure.
Article
Physiology
Zitian Wang, Xue Zhao, Lifang Bu, Kun Liu, Ziping Li, Huaxing Zhang, Xiaoguang Zhang, Fang Yuan, Sheng Wang, Zan Guo, Luo Shi
Summary: The purpose of this study was to investigate the effects of sodium restriction on hypertension and left ventricular hypertrophy in a mouse model of primary aldosteronism. The study found that adult male mice with genetic deletion of TWIK-related acid-sensitive K-1 and TASK-3 channels exhibited hypertension and LV hypertrophy, which were ameliorated by a low-sodium intake. Untargeted metabolomics analysis revealed disturbances in heart metabolism in these mice, some of which were reversed after sodium restriction. These findings suggest that sodium restriction may play a role in preventing or reducing hypertension and LV hypertrophy in individuals with primary aldosteronism.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Tomasz K. Bednarski, Monika K. Duda, Pawel Dobrzyn
Summary: Disturbances in cardiac lipid metabolism are associated with the development of cardiac hypertrophy and heart failure in spontaneously hypertensive rats. Triglyceride accumulation in cardiomyocytes, due to lower rates of lipolysis and beta-oxidation, is linked to the development of left ventricular hypertrophy and myocardial dysfunction in SHR.
Article
Cardiac & Cardiovascular Systems
Matthew Hoffman, Dimitra Palioura, Ioannis D. Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P. Christian Schulze, Ira J. Goldberg, Raj Kishore, Vincent W. Yang, Thomas D. Bannister, Agnieszka B. Bialkowska, Craig H. Selzman, Stavros G. Drakos, Konstantinos Drosatos
Summary: KLF5 is found to play a crucial role in the pathophysiology of ischemic heart failure, involving regulation of lipid metabolism. Genetic or pharmacological inhibition of KLF5 prevents ceramide accumulation, alleviates cardiac remodeling, and improves ejection fraction in mice with myocardial infarction.
Article
Pharmacology & Pharmacy
Xia Wu, Fei Yang, Lili Sun
Summary: This study evaluated the characteristics and influencing factors of computed tomography myocardial perfusion imaging (CT-MPI) in patients with left ventricular hypertrophy (LVH) caused by hypertension. The results showed that patients with LVH had lower myocardial blood flow but stable myocardial blood volume. In hypertensive patients, decreased myocardial blood flow was significantly correlated with increased left ventricular mass index.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Genetics & Heredity
Marguerite R. Irvin, Praful Aggarwal, Steven A. Claas, Lisa de Las Fuentes, Anh N. Do, C. Charles Gu, Andrea Matter, Benjamin S. Olson, Amit Patki, Karen Schwander, Joshua D. Smith, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amy J. Turner, Deborah A. Nickerson, Dabeeru C. Rao, Ulrich Broeckel, Donna K. Arnett
Summary: This study conducted an exome-wide association study in African Americans, identifying three genes (MYRIP, TRAPPC11, and SLC27A6) that may be associated with LV hypertrophy. Functional validation of these genes provided new insights into hypertrophic pathways.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Wen Han, Shuxian Yang, Haiyan Xiao, Min Wang, Jingxue Ye, Li Cao, Guibo Sun
Summary: This article summarizes the role of adiponectin in the treatment of cardiovascular diseases related to glucose and lipid metabolism disorders, including beneficial effects on metabolism regulation and protection of myocardial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie A. Noll, Lance A. Riley, Christy S. Moore, Lin Zhong, Mathew R. Bersi, James D. West, Roy Zent, W. David Merryman
Summary: This study found that the absence of Tln1 and Tln2 in cardiac fibroblasts leads to cardiomyocyte hypertrophy in response to ANG II in male mice, but results in a hypertrophy-resistant phenotype in female mice.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qiong Jiang, Xianfeng Dong, Danqing Hu, Lejun Chen, Yukun Luo
Summary: The study utilized a mouse myocardial cell line HL-1 to investigate the effects of Aqp4 inhibition on myocardial ischemia-reperfusion injury. Aqp4 inhibition effectively improved apoptotic cells in HL-1 and alleviated myocardial ischemia-reperfusion injury. Treatment with Aqp4i regulated the expression of apoptotic proteins and anti-apoptotic proteins in HL-1, offering new insights into managing myocardial ischemia-reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cell Biology
Dongliang Fu, Tong Gao, Mengru Liu, Chunyan Li, Haiwei Li, Hong Jiang, Xianlun Li
Summary: Research shows that TUG1 plays a crucial role in apoptosis during myocardial ischemia/reperfusion, indicating its potential as a biomarker for patients with acute myocardial infarction and a target for treating myocardial ischemia/reperfusion injury.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Cell Biology
Jun Lin, Qinfeng Li, Tingting Jin, Jiacheng Wang, Yingchao Gong, Qingbo Lv, Meihui Wang, Jiawen Chen, Min Shang, Yanbo Zhao, Guosheng Fu
Summary: IL-1R2 plays a protective role in myocardial I/R injury by protecting cardiomyocytes from apoptosis. Overexpression of IL-1R2 can protect cardiomyocytes from apoptosis by reducing the expression of IL-17RA.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan Carl Luis Rodrigues, Benjamin Rooms, Katie Hyde, Stephen Rohan, Angus K. Nightingale, Julian Paton, Nathan Manghat, Chiara Bucciarelli-Ducci, Mark Hamilton, Henggui Zhang, David H. MacIver
Summary: The study utilized cardiac MRI to quantify independent geometric factors determining Left Ventricular Ejection Fraction (LVEF) and provided an improved measure of ventricular function. Adjusting wall thickness and ventricular size to the control group mean improved understanding of myocardial mechanics and reclassified ventricular function in some individuals, especially in thick-walled, low-volume ventricles. The new approach, EFc, offers enhanced quantification of geometric changes and strain effects, leading to a better assessment of myocardial performance.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Review
Health Care Sciences & Services
Yi Gao, Di Zhou, Ping Yang
Summary: This study found that amlodipine treatment in patients with hypertension significantly reduced LV hypertrophy, lowered SBP and DBP, as well as decreased LV mass index and LV posterior wall thickness.
ANNALS OF PALLIATIVE MEDICINE
(2021)